Significance of age-related predictors of chronic heart failure in determining risk of death in elderly patients with hypertension

Changes in gut microbiota linked to a prevention of cardiac remodeling induced by hypertension in spontaneously hypertensive rats fed a pawpaw fruit diet

“…Cardiac remodeling, characterized by cardiac hypertrophy and fibrosis, is one of the most common complications of hypertension, and has been found to be an independent determinant of prognosis in hypertension [ 17 ]. Clinical studies showed that hypertension is a lower-grade chronic inflammatory disease, while inflammtion is also a critical pathologic feature in cardiac remodeling induced by hypertension.…”

Abordagem de Bioinformática e Biologia de Sistemas para Identificar a Ligação Patogenética entre Insuficiência Cardíaca e Sarcopenia

“… 30 , 31 Foi relatado que níveis elevados de pressão arterial e glicose estão associados ao aumento da incidência de IC e sarcopenia. 32 , 33 TIMP2, juntamente com outros membros da família de genes TIMP, inibem metaloproteinases de matriz (MMPs). 34 MMPs, incluindo MMP-1, -2, -3, -9 e -19, são peptidases que degradam a matriz extracelular.…”

“… 30 , 31 Raised blood pressure and glucose levels are reported to be associated with increased incidence of HF and Sarcopenia. 32 , 33 TIMP2, together with other members of the TIMP gene family, inhibit matrix metalloproteinases (MMPs). 34 MMPs, including MMP-1, -2, -3, -9, and -19, are peptidases that degrade the extracellular matrix.…”