Changes in gut microbiota linked to a prevention of cardiac remodeling induced by hypertension in spontaneously hypertensive rats fed a pawpaw fruit diet

Chen, Kai; Wu, Shaoyu; Guan, Yiqing; Ma, Yunci; Huang, Yu; Liu, Xin; Quan, Dongling; Zhang, Jingru; Lv, Lin; Zhang, Guohua

doi:10.1016/j.heliyon.2023.e15576

Cited by 4 publications

(2 citation statements)

References 45 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another report by Wang et al showed that Bifidobacterium pseudolongum and Clostridium butyricum attenuate the development of cardiac fibrosis in mice [199]. However, it is important to note that the topic of probiotics is complex as they can impact the gut microbiome, and an increasing number of studies are exploring their role in various disease states [200]. Further research is necessary to fully understand the mechanisms by which probiotics influence cardiac fibrosis and their overall effects on the gut microbiome in the context of different disease conditions.…”

Section: Probioticsmentioning

confidence: 99%

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Majid

Hassan

Hoque

et al. 2023

JCDD

View full text Add to dashboard Cite

Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review aims to provide a thorough overview of the mechanisms underlying cardiac fibrosis, address the limitations of current treatment strategies, and specifically explore the potential of bioactive compounds as therapeutic interventions for the treatment and/or prevention of cardiac fibrosis.

show abstract

Section: Probioticsmentioning

confidence: 99%

Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect

Majid

Hassan

Hoque

et al. 2023

JCDD

View full text Add to dashboard Cite

show abstract

“…The latest investigations suggest that butyrate prevents hypertension and inflammation [137]. Several recent clinical studies support that SCFAs play a beneficial role in the prevention and treatment of human diseases, such as regulation of cardio-metabolic outcomes [130], improvement of gut barrier integrity [138], regulating cardiac function [139], modulation of glucose and lipid metabolism [140], and mediation of the immune system promoting insulin secretion [141], increasing energy expenditure and reducing fat accumulation [142] and anti-inflammatory response [143].…”

Section: Production Of Metabolitesmentioning

confidence: 99%

Bioactive Components in Fruit Interact with Gut Microbes

Jin,

Chen,

et al. 2023

Biology

View full text Add to dashboard Cite

Fruits contain many bioactive compounds, including polysaccharides, oligosaccharides, polyphenols, anthocyanins, and flavonoids. All of these bioactives in fruit have potentially beneficial effects on gut microbiota and host health. On the one hand, fruit rich in active ingredients can act as substrates to interact with microorganisms and produce metabolites to regulate the gut microbiota. On the other hand, gut microbes could promote health effects in the host by balancing dysbiosis of gut microbiota. We have extensively analyzed significant information on bioactive components in fruits based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Although the deep mechanism of action of bioactive components in fruits on gut microbiota needs further study, these results also provide supportive information on fruits as a source of dietary active ingredients to provide support for the adjunctive role of fruits in disease prevention and treatment.

show abstract