Significance of a Multiple Biomarkers Strategy Including Endothelial Dysfunction to Improve Risk Stratification for Cardiovascular Events in Patients at High Risk for Coronary Heart Disease

Nozaki, Toshimitsu; Sugiyama, Seigo; Koga, Hidenobu; Sugamura, Koichi; Ohba, Keisuke; Matsuzawa, Yasushi; Sumida, Hitoshi; Matsui, Kunihiko; Jinnouchi, Hideaki; Ogawa, Hisao

doi:10.1016/j.jacc.2009.05.022

Cited by 257 publications

(177 citation statements)

References 35 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…Preliminary data reported that baseline values of circulating CD62e + microparticles, measured before initiation of any specific therapy, predicted occurrence of adverse outcome (death and readmission for right heart failure) in a small cohort of patients with mixed aetiologies of PH [26]. Whereas these results were not observed for other EMP subsets (CD144 + and CD31 + EMPs) and should be confirmed in a larger population sample, they are in line with data reported in coronary artery disease [27], heart failure [28] and chronic end-stage renal failure [29], and thus confirm their potential role as a biomarker for outcome prediction in patients with cardiovascular diseases [30].…”

Section: Pulmonary Hypertension | N Amabile Et Alsupporting

confidence: 75%

Cellular microparticles in the pathogenesis of pulmonary hypertension

et al. 2012

View full text Add to dashboard Cite

Pulmonary hypertension (PH) is a fatal disease with no treatment options, characterised by elevated pulmonary vascular resistanzce and secondary right ventricular failure. The aetiology of pulmonary arterial hypertension is multiple and its pathogenesis is complex. Although the exact role of cellular microparticles remains partially understood, there is increasing evidence to suggest an active role for microparticles in PH pathophysiology. Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study. @ERSpublications Patients with PH have elevated circulating levels of microparticles which may contribute to disease pathophysiology

show abstract

Section: Pulmonary Hypertension | N Amabile Et Alsupporting

confidence: 75%

Cellular microparticles in the pathogenesis of pulmonary hypertension

et al. 2012

View full text Add to dashboard Cite

show abstract

“…95 More recently, the hsCRP level improved the predictive value of the FRS in patients at high risk for coronary heart disease. 96 The independent prognostic value of the hsCRP level was also evident in a meta-analysis of 160,309 people without a history of vascular disease (ie, 1.31 million personyears at risk and 27,769 fatal or nonfatal disease outcomes) from 54 long-term prospective studies. 97 Ridker 98 reviewed evidence that hsCRP level correctly reclassifies a substantial proportion of patients at intermediate risk for CVD into clinically relevant higher-or lower-risk groups.…”

Section: Treatment Additional Cardiovascular Evaluation and Referralmentioning

confidence: 90%

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Nehra

Jackson

Miner

et al. 2012

Mayo Clinic Proceedings

417

341

View full text Add to dashboard Cite

The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The third Princeton Consensus met November 8 to 10, 2010, and had 2 primary objectives. The first objective focused on the evaluation and management of cardiovascular risk in men with erectile dysfunction (ED) and no known cardiovascular disease (CVD), with particular emphasis on identification of men with ED who may require additional cardiologic work-up. The second objective focused on reevaluation and modification of previous recommendations for evaluation of cardiac risk associated with sexual activity in men with known CVD. The Panel's recommendations build on those developed during the first and second Princeton Consensus Conferences, first emphasizing the use of exercise ability and stress testing to ensure that each man's cardiovascular health is consistent with the physical demands of sexual activity before prescribing treatment for ED, and second highlighting the link between ED and CVD, which may be asymptomatic and may benefit from cardiovascular risk reduction. T he Princeton Consensus Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The first conference convened in June 1999 to develop recommendations for clinical management of sexual dysfunction in men and women with known cardiovascular disease (CVD). This conference also provided a multidisciplinary forum for evaluation of the potential cardiovascular risk posed by sexual activity in atrisk patients. The first Princeton Consensus Conference recommendations 1 included stratification of patients by level of cardiac risk associated with sexual activity based on existing CVD. Those at low risk could initiate or resume sexual activity and be treated for sexual dysfunction. For those at high risk, sexual activity was deferred until the cardiac condition was stabilized. The second Princeton Consensus Conference convened in June 2004 and expanded the recommendations of the first conference to emphasize risk factor evaluation and lifestyle management for all men with erectile dysfunction (ED). 2 The second conference recommendations also incorporated new information on the appropriate use of phosphodiesterase type 5 (PDE5) inhibitors in men with ED and concomitant CVD.The third Princeton Consensus Conference took place November 8 to 10, 2010, in Miami Beach, Florida. The group revisited and updated their 2005 recommendations regarding the cardiovascular risk associated with sexual activity in men with known CVD. 2 In addition, the third conference focused on the predictive value of vasculogenic ED in assigning cardiovascular risk in men of all ages, with the primary objective being development of an approach to cardiovascular risk assessment in younger men with ED and no known CVD. The role of testosterone in erectile function and cardiovascular health and the utility of testosterone replacement...

show abstract

“…In particular, acute reactions to infectious agents are associated with an increased risk of both arterial ischaemic events and VTE and are accompanied by both arterial and venous endothelial dysfunction (40,43,44); increased circulating levels of some biomarkers of endothelial dysfunction, like endothelial microparticles or P-selectin, are associated with both an enhanced risk of cardiovascular events and of VTE (45)(46)(47); recent data have shown in patients with VTE an increase of circulating fibronectin, an endothelium-released plasma factor previously shown to correlate with arterial endothelial dysfunction (48,49); several other clinical conditions characterised by an impaired arterial endothelial function, like airpollution, chronic HIV infection, a family history of myocardial infarction, the metabolic syndrome, rheumatoid arthritis and microalbuminuria, have been reported to be associated not only with an increased risk of arterial events but also of venous thrombosis (12,14,16,19,21,22,(50)(51)(52).…”

Section: (ǡTable 2)mentioning

confidence: 99%

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Gresele

Momi

Migliacci³

2010

Thromb Haemost

View full text Add to dashboard Cite

SummaryThe association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of ex- perimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.

show abstract

Significance of a Multiple Biomarkers Strategy Including Endothelial Dysfunction to Improve Risk Stratification for Cardiovascular Events in Patients at High Risk for Coronary Heart Disease

Cited by 257 publications

References 35 publications

Cellular microparticles in the pathogenesis of pulmonary hypertension

Cellular microparticles in the pathogenesis of pulmonary hypertension

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Contact Info

Product

Resources

About