Signet-ring sinus histiocytosis

Guerrero-Medrano, Jaime; Delgado, Ruby; Albores‐Saavedra, Jorge

doi:10.1002/(sici)1097-0142(19970715)80:2<277::aid-cncr16>3.0.co;2-r

Cited by 33 publications

(3 citation statements)

References 21 publications

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“…The authors concluded that the cytoplasmic vacuoles derived from the accumulation of fat within histiocytes were a result of the derangement of fatty metabolism in diabetes. Since then, other cases have been reported in axillary and pelvic lymph nodes of nondiabetic patients, and the lipid nature of the signet-ring histiocytes has been proved by electron microscopy [50,51]. The pathogenesis of this change remains unclear, some authors having hypothesized that the lipid accumulation within the sinusoidal histiocytes is of reactive nature, sometimes related to previous surgical interventions with disruption of adipose tissue [50].…”

Section: Discussionmentioning

confidence: 99%

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

2009

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Section: Discussionmentioning

confidence: 99%

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

2009

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“…Signet ring cell carcinoma is a particular pathological type of carcinoma that contains mucilage pushing the nucleus to the periphery, causing the cancer cell to resemble a signet-ring [1–3]. It has been estimated that 3.5–5.0% of all esophageal cancers are SRCCE [4–6].…”

Section: Introductionmentioning

confidence: 99%

Survival predictors associated with signet ring cell carcinoma of the esophagus (SRCCE): A population-based retrospective cohort study

2017

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PurposeSignet ring cell carcinoma of the esophagus (SRCCE) is an uncommon tumor associated with significant morbidity and mortality. There is still no consensus regarding cut-off values for tumor size, age and optimal treatment for SRCCE. Thus, we elucidated the current survival outcomes of patients with SRCCE and analyzed factors associated with prognosis.MethodsA retrospective cohort study based on the SEER (The Surveillance, Epidemiology, and End Results) program database was conducted. We identified 537 patients (461 men and 76 women) newly diagnosed with SRCCE between January 2004 and December 2014. A multivariate Cox proportional hazards model was utilized to measure the mortality-associated risk factors in patients with SRCCE after adjusting for various variables.ResultsThe 1-, 2- and 5-year disease-specific mortalities (DSM) were 51.6%, 67.6%, and 78.4%, respectively, and the median survival time was 12.0 months. The factors correlated with mortality hazard were marital status (unmarried versus married, Hazard Ratio (HR) = 1.443), tumor size (≥ 5 cm versus < 5 cm, HR = 1.444), tumor grade (high grade versus low grade, HR = 3.001), condition of primary tumor (T4 versus T1, HR = 2.178), regional lymph node metastasis (N1 versus N0, HR = 1.739), further metastasis (M1 versus M0, HR = 1.951) and chemotherapy (receiving chemotherapy versus no chemotherapy, HR = 0.464).ConclusionsThe contemporary 5-year DSM was 78.4%. Being unmarried, having a tumor size ≥ 5 cm, a high tumor grade, a score of T4 for tumor invasion of adjacent organs, a score of N1 for regional lymph node metastasis, a score of M1 for distant metastasis and no chemotherapy were independent predictors of high DSM.

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“…The significance of this association varies, although a more favorable prognosis has been reported [20–22]. On occasion, the histiocytes may have a signet ring appearance, which may be mistaken for metastatic signet ring carcinoma or melanoma; however, the distinction is easily made by immunohistochemistry and special stains, as the histiocytes are positive with CD68 and negative for cytokeratin, S100 and mucin stains, although they may contain Periodic Acid-Schiff (PAS) positive globules [23–25].…”

Section: Histiocytic (Macrophage) Infiltratesmentioning

confidence: 99%

Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes

Egan

Jaffe

2018

Seminars in Diagnostic Pathology

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Benign and malignant proliferations of histiocytes and dendritic cells may be encountered in lymph nodes. Reactive histiocytic and dendritic cell infiltrates occur in response to diverse stimuli and in addition to causing lymphadenopathy, may be present unexpectedly in lymph nodes excised for other indications. This review summarizes the pathogenesis and histopathological features of the various non-neoplastic histiocytic and dendritic cell infiltrates that can occur in lymph nodes.

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Signet-ring sinus histiocytosis

Cited by 33 publications

References 21 publications

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Survival predictors associated with signet ring cell carcinoma of the esophagus (SRCCE): A population-based retrospective cohort study

Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes

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