Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes

Egan, Caoimhe; Jaffe, Elaine S.

doi:10.1053/j.semdp.2017.11.002

Cited by 14 publications

(14 citation statements)

References 186 publications

(267 reference statements)

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“…Currently, histiocytes are considered to be tissue macrophages that are differentiated from the monocyte lineage, including alveolar macrophages in the lung, Kupffer cells in the liver, Langerhans cells in the skin, and dendritic cells in the germinal centers of lymph nodes [ 14 ]. These cells (histiocytes) play an important role in antigen presentation, phagocytosis, and removal of pathogens and cellular debris, and can be found anywhere on the human body including the PE [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Histiocytic pleural effusion: the strong clue to malignancy

et al. 2021

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Background There have been many studies on the clinical characteristics of neutrophilic, lymphocytic, and/or eosinophilic pleural effusion. While caring for patients with pleural effusion, we found that histiocytic pleural effusion (HisPE) was not uncommon. However, few studies have explored HisPE. The purpose of the present study was to determine the clinical characteristics and etiologies of HisPE. Methods In this retrospective study, HisPE was defined as pleural fluid white blood cells comprised of ≥ 50% histiocytes. Using a clinical data warehouse, patients with HisPE among all patients aged >18 years who underwent thoracentesis and pleural fluid analysis between January 2010 and December 2019 at Ulsan University Hospital were enrolled. A total of 295 (9.0%) of 3279 patients who underwent thoracentesis were identified as HisPE patients. Among them, 201 with exudative HisPE were included. Clinical characteristics and etiologies were extracted from medical records and analyzed. Results Among the 201 patients with exudative HisPE, the major causes were malignant pleural effusion (n = 102 [50.7%]), parapneumonic effusion (n = 9 [4.5%]), and tuberculous pleurisy (n = 9 [4.5%]). In the 102 patients with malignant pleural effusion, the main types of cancer were lung (n = 42 [41.2%]), breast (n = 16 [15.7%]), and stomach cancer (n = 11 [10.8%]). Among lung cancers, adenocarcinoma (n = 34 [81.0%]) was the most common histology. Conclusions The leading cause of exudative HisPE was malignancy, particularly lung cancer. Physicians should consider the possibility of malignant disease if histiocytes are predominantly present in pleural effusion.

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Section: Discussionmentioning

confidence: 99%

Histiocytic pleural effusion: the strong clue to malignancy

et al. 2021

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“…[216] However, zinc supplements should not be administered alone, because many in the developing world have several deficiencies, and zinc interacts with other micronutrients. [217] While zinc deficiency is usually due to insufficient dietary intake, it can be associated with malabsorption, acrodermatitis enteropathica, chronic liver disease, chronic renal disease, sickle cell disease, diabetes, malignancy, and other chronic illnesses. [10] In the United States, a federal survey of food consumption determined that for women and men over the age of 19, average consumption was 9.7 and 14.2 mg/day, respectively.…”

Section: Deficiency Iron Deficiencymentioning

confidence: 99%

Investigating Covid- 19 and Prophylactive Measures to Contain Spread of the Disease

2021

JBAH

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disease is a highly infectious and contagious disease and the outbreak has caused high mortality and morbidity with rates of about 5% and 0.9% it is a global pandemic requiring immediate attention,some of the symptoms include Anemia ,dehydration,Emaciation,weakness ,pneumonitis and Death. The etiology is covid-19 ,the problem at the moment is the lack of cure for the disease.In this study five continents where of interest and they include North and South America,Europe,Africa and Asia.Data was obtained from the internet from worldometer.info/coronavirus/country and cases from February to 15 december 2020 were considered and analysed statistically using analysis of variants to determine monthly incidence and prevalence,case fatality,morbidity ,mortality and population at risk.The reason for this survey is to establish ways to decrease the high morbidity and mortality rates , reduce the devastating economic impact of this disease and increase daily socialization among Humans and curb hunger and boredom that covid-19 has caused.More so the it is a global pandemic needing urgent attention.In conclusion the morbidity and mortality where highest in the months of July and October and the population at risk are 95%-98%.Prophylactic measure to help alleviate the incidence of this disease include daily administration of blood tonic and ascorbic acid in their daily recommended dosages preinfection to enhance growth of tissues and cellular epithelization and boost energy generation and build .

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“…Giant cell tumor is basically composed of several types of cells such as; mononuclear histiocytic cells, multi-nucleated giant cells and these cells work in combination under a specific environment called as; monocytic-histiocytic system [50]. Giant cell tumor stromal cells (GCTSCs) are the cells which belong to neoplastic tumor and exhibit proliferation at high level.…”

Section: Giant Cell Tumor Of Bone (Gctb)mentioning

confidence: 99%

Role of cancer stem cells in the development of giant cell tumor of bone

et al. 2020

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The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and is usually associated with the end point of a long bone. Giant cell tumor (GCT) involves mononuclear stromal cells which proliferate at a high rate, multinucleated giant cells and stromal cells are equally present in this type of tumor. Cancer stem cells (CSCs) have been confirmed to play a potential role in the development of GCT. Cancer stem cell-based microRNAs have been shown to contribute to a greater extent in giant cell tumor of bone. CSCs and microRNAs present in the tumors specifically are a great concern today which need indepth knowledge as well as advanced techniques to treat the bone cancer effectively. In this review, we attempted to summarize the role played by cancer stem cells involving certain important molecules/factors such as; Mesenchymal Stem Cells (MSCs), miRNAs and signaling mechanism such as; mTOR/PI3K-AKT, towards the formation of giant cell tumor of bone, in order to get an insight regarding various effective strategies and research advancements to obtain adequate knowledge related to CSCs which may help to focus on highly effective treatment procedures for bone tumors.

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Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes

Cited by 14 publications

References 186 publications

Histiocytic pleural effusion: the strong clue to malignancy

Histiocytic pleural effusion: the strong clue to malignancy

Investigating Covid- 19 and Prophylactive Measures to Contain Spread of the Disease

Role of cancer stem cells in the development of giant cell tumor of bone

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