Signet Ring Cell Carcinoma of the Lung: A Diagnostic Pitfall in Pregnancy

Danzinger, Sabine; Köstler, Wolfgang J.; Funovics, Martin; Herac, Merima; Müllauer, Leonhard; Prosch, Helmut; Kölbl, H.

doi:10.1155/2019/9461579

Cited by 3 publications

(1 citation statement)

References 49 publications

(60 reference statements)

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“…Our patient failed to demonstrate any active malignancy of initial PET scan in other organ systems and underwent EGD with biopsies to rule out gastric origin of cancer. This conclusion is further supported with immunohistochemistry (positive CK7 and TTF-1 and negative CK20) which suggests primarily a lung cancer [ 7 ]. Fluorescence in situ hybridization (FISH) in primary lung SRCC may often demonstrate ALK gene translocation with EML4-ALK fusion and absence of EGFR and KRAS mutations.…”

Section: Discussionmentioning

confidence: 74%

Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Anwar

Acharya

Elsayegh

et al. 2020

Respiratory Medicine Case Reports

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Primary signet ring cell carcinoma of the lung is a rare non-small cell carcinoma of the lung with extremely aggressive features and poor prognosis. The diagnosis mainly required tissue biopsy with immunohistochemical analysis and gene mutation studies. We describe a unique case of primary signet ring cell carcinoma of the lung presenting with life threatening haemoptysis along with literature review of prognosis and management of this rare clinical entity.

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Section: Discussionmentioning

confidence: 74%

Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Anwar

Acharya

Elsayegh

et al. 2020

Respiratory Medicine Case Reports

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Signet-ring cell adenocarcinoma of unknown primary presenting with superior vena cava (SVC) syndrome: rare type of cancer

et al. 2019

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A 53-year-old man presented with a 3-month history of progressive, non-productive cough followed by occasional swelling of the face and upper extremities. Physical examination on admission revealed prominent superficial vessels at the neck and upper extremity swelling. Bronchoscopy revealed the superior segment of the right lower lobe was narrow but without visible mass; cell block and biopsy done revealed signet-ring cell carcinoma with an immunohistochemistry pattern favouring the primary site of malignancy as either gastric or of the pancreaticobiliary tree. However, CT scan of the abdomen and pelvis with triple contrast revealed only slight gastric wall thickening; the pancreas was unremarkable. The patient underwent radiotherapy with noted improvement of symptoms. He was then discharged with plans for further work-up on an outpatient basis. This work highlights the importance of a comprehensive histopathological and immunohistochemical work-up which can help predict a site of origin to be able to provide the appropriate management.

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Primary Signet-Ring Cell Carcinoma of the Lung: A Case Report: Diagnosis, Treatment and Literature Report

王¹

2022

ACM

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Signet Ring Cell Carcinoma of the Lung: A Diagnostic Pitfall in Pregnancy

Abstract: Lung cancer during pregnancy represents a rare disease. In this case report, we present a patient at advanced and metastasized stage of signet ring cell carcinoma who presented in the 22nd week of gestation.

Cited by 3 publications

References 49 publications

Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Signet-ring cell adenocarcinoma of unknown primary presenting with superior vena cava (SVC) syndrome: rare type of cancer

Primary Signet-Ring Cell Carcinoma of the Lung: A Case Report: Diagnosis, Treatment and Literature Report

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