Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Anwar, Shamsuddin; Acharya, Sudeep; Elsayegh, Dany; Sokoloff, Alisa; Rehan, Maryam

doi:10.1016/j.rmcr.2020.101195

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Immunostaining for ALK and FISH analysis (break-apart assay) supported the presence of ALK gene rearrangement in the present case, which is in agreement with previous reports of the strong association of an SRCC component in lung carcinomas with ALK gene rearrangement [ 6 , 9 - 11 ]. Crizotinib, a small-molecule tyrosine kinase inhibitor, has been shown to have clinical superiority as compared to standard chemotherapy in patients treated for a tumor with an ALK gene rearrangement.…”

Section: Discussionsupporting

confidence: 93%

Primary Lung Adenocarcinoma With ALK Gene Rearrangement Mostly Occupied by the Signet-Ring Cell Carcinoma Component: A Case Report

Okimura,

Hirano,

Ito

et al. 2023

Cureus

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Primary lung carcinoma tumors possessing a signet-ring cell carcinoma (SRCC) component at varying proportions are rare, while those primarily composed of an SRCC component are much rarer. Reported here is a case of primary lung adenocarcinoma primarily composed of an SRCC component with a scant acinar component that developed in an 81-year-old male. Approximately 95% of the adenocarcinoma was occupied by an SRCC component that was shown to be diastase-resistant based on positive periodic acid-Schiff staining. Immunostaining for ALK and fluorescence in situ hybridization analysis (break-apart assay) showed the presence of an ALK gene rearrangement. Findings in this case indicated a primary lung adenocarcinoma with ALK gene rearrangement, in which an SRCC component accounted for approximately 95% of the tumor.

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Section: Discussionsupporting

confidence: 93%

Primary Lung Adenocarcinoma With ALK Gene Rearrangement Mostly Occupied by the Signet-Ring Cell Carcinoma Component: A Case Report

Okimura,

Hirano,

Ito

et al. 2023

Cureus

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“…In our patient it was not possible to demonstrate any active neoplasm on PET study in other organs, excluding specifically a gastric origin of the cancer. This conclusion was further supported by immunohistochemistry, which mainly suggested lung carcinoma 7 . In fact, double TTF‐1 and Napsin A positive immunostaining (Figure 3(d),(f), respectively) is highly specific for primary lung adenocarcinoma 8 .…”

Section: Discussionmentioning

confidence: 59%

Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

et al. 2021

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Primary lung signet‐ring cell carcinomas are a rare entity and only a few cases of pure signet‐ring cell carcinomas of the lung are reported in the English literature. They usually have an aggressive behavior and a poor prognosis because in most cases they are identified at an advanced stage. We present a unique case of primary signet‐ring cell carcinoma of the lung because the patient was HIV positive, a heavy smoker, and also the tumor, discovered incidentally during chest x‐ray, was a pure type of signet‐ring cell carcinoma. Surgical therapy associated with chemoradiotherapy represents the gold standard in the care of these patients.

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Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma

Cited by 2 publications

References 11 publications

Primary Lung Adenocarcinoma With ALK Gene Rearrangement Mostly Occupied by the Signet-Ring Cell Carcinoma Component: A Case Report

Primary Lung Adenocarcinoma With ALK Gene Rearrangement Mostly Occupied by the Signet-Ring Cell Carcinoma Component: A Case Report

Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

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