Signet ring cell carcinoma of breast: Single center experience.

Akın, Serkan; Diker, Ömer; Kertmen, Neyran; Ateş, Öztürk; Dizdar, Ömer; Yalçın, Şuayib; Altundağ, Kadri̇

doi:10.1200/jco.2015.33.15_suppl.e11513

Cited by 4 publications

(3 citation statements)

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“…Of these 25 cases, most were ER+ and HER2−, as was our patient. Additionally, 19 of 25 (76%) had a mixed histology, only 6 (24%) of which were SRCC with invasive lobular carcinoma as seen with our patient [ 4 ]. Thus, per this study’s estimation our patient’s histotype represents only 0.17% of all breast cancer diagnoses.…”

Section: Discussionmentioning

confidence: 69%

“…As primary breast SRCC is so rare, there are few studies describing its patterns of metastatic dissemination, particularly for cases co-mixed with invasive lobular carcinoma. The aforementioned study has provided some insight into primary breast SRCC metastasis, as 7 of 25 (28%) primary breast SRCC patients developed distant metastases, with secondary lesions observed in the bone, liver and ovaries [ 4 ]. The ovary appears to be the most frequently reported site of primary breast SRCC metastasis, though two additional cases of gastric metastases from primary breast SRCC have been reported [ 5–7 ].…”

Section: Discussionmentioning

confidence: 99%

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Perforating duodenal ulcer with umbilical herniation as a metastatic complication of primary signet ring cell carcinoma of the breast

Principe

Raicu

Cataneo

et al. 2021

Journal of Surgical Case Reports

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Primary signet ring cell carcinoma (SRCC) of the breast is extremely rare, and the associated patterns of metastatic dissemination poorly described. Here, we report the case of a 61-year-old woman presenting with acute abdominal pain. Esophagogastroduodenoscopy revealed a non-bleeding erosive gastropathy, which was biopsied and found significant for a poorly differentiated, GATA3-positive SRCC. The patient was lost to follow up until re-presenting 6 months later with a perforating duodenal ulcer and umbilical herniation. Biopsies of umbilical hernia sack contents were significant for an estrogen receptor (ER) positive SRCC, and breast examination identified a right breast mass significant for an ER positive lobular carcinoma with signet ring features, thereby affirming the diagnosis of metastatic SRCC of the breast. This case offers insight into an advanced form of a rare clinical entity, and suggests that staining for breast markers such as GATA3 should be considered for all biopsies significant for SRCC.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Perforating duodenal ulcer with umbilical herniation as a metastatic complication of primary signet ring cell carcinoma of the breast

Principe

Raicu

Cataneo

et al. 2021

Journal of Surgical Case Reports

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“…It is classified under "mucin-producing carcinomas" in 2003 WHO classification. [1][2] This histological type can be found in association with infiltrating lobular carcinoma, ductal carcinoma but also in its pure form which remains extremely rare. [3][4]…”

Section: Introductionmentioning

confidence: 99%

Signet Ring Cell Carcinoma of the Breast: About A Case and Literature Review

Acharfi

Boujarnija

Messoudi

et al. 2020

ijirms

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Singnet ring cell carcinoma of the breast is a rare and aggressive tumor. We report the case of a 44-year-old woman with signet ring cell carcinoma of breast who was treated in the gynecology and medical oncology departments of HASSAN II Hospital University in Fez. She received a neoadjuvant chemotherapy with the anthracyclines and taxanes. After she had radical mastectomy and radiotherapy. Currently she has remained in good control.

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18F-fluorodeoxyglucose positron emission tomography/computed tomography findings of breast cancer with signet ring cell differentiation: A single-center experience

ALÇIN,

ARSLAN

2023

Anadolu Kliniği Tıp Bilimleri Dergisi

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Aim: Due to the low incidence of breast cancer with signet ring cell (SRC) differentiation, which constitutes less than 1% of all breast cancers, little is known about its imaging features. The aim of this study was to evaluate the utility of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in staging breast cancer with SRC differentiation. Methods: We conducted a retrospective analysis of 14 patients with histologically confirmed breast cancer with SRC differentiation who underwent 18F-FDG PET/CT at our institution between 2014 and 2023. The imaging findings were analyzed in terms of maximum standardized uptake value (SUVmax), lesion size, and the presence of regional or distant metastases were statistically evaluated. Results: The histological subtypes of SRC differentiated primary tumors were 9 invasive lobular, and 5 invasive ductal carcinoma. More intense 18F-FDG uptake was observed in primary tumoral lesions of the ductal subtype (mean SUVmax: 18.8±9.8; range: 2.6–28.9) compared to the lobular subtype (mean SUVmax: 2.6±1.3; range: 1.5–5.1) (p=0.007, Z=2.600). Among the patients included in the study, axillary lymph node metastasis was present in 64% (n=9) of the cases, with lymph node metastasis identified in five cases classified as ductal carcinoma. Additionally, distant organ metastasis was identified in 21% (n=3) of patients, comprising two patients with ductal carcinoma and one with lobular carcinoma. Conclusion: Despite the general consensus that signet-ring cell tumors have a low affinity for 18F-FDG, our study has observed the possibility of high 18F-FDG uptake in cases of ductal carcinoma. However, in cases of lobular carcinoma, where 18F-FDG uptake tends to be low, considering alternative PET radiopharmaceuticals for imaging could be a viable option.

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Signet ring cell carcinoma of breast: Single center experience.

Cited by 4 publications

References 0 publications

Perforating duodenal ulcer with umbilical herniation as a metastatic complication of primary signet ring cell carcinoma of the breast

Perforating duodenal ulcer with umbilical herniation as a metastatic complication of primary signet ring cell carcinoma of the breast

Signet Ring Cell Carcinoma of the Breast: About A Case and Literature Review

18F-fluorodeoxyglucose positron emission tomography/computed tomography findings of breast cancer with signet ring cell differentiation: A single-center experience

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