Signalling through pigment dispersing hormone-like peptides in invertebrates

Meelkop, Ellen; Temmerman, Liesbet; Schoofs, Liliane; Janssen, Tom

doi:10.1016/j.pneurobio.2010.10.004

Cited by 52 publications

(55 citation statements)

References 231 publications

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“…The PDF neuropeptide occurs in tsetse brain and PM samples. This is in accordance with Drosophila where besides expression in certain brain neurons, PDF is also found in neurons innervating the most caudal part of the midgut and hindgut [99].…”

Section: Pigment Dispersing Factorsupporting

confidence: 89%

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Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Caers

Boonen

Abbeele³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Neuropeptides and peptide hormones are essential signaling molecules that regulate nearly all physiological processes. The recent release of the tsetse fly genome allowed the construction of a detailed in silico neuropeptide database (International Glossina Genome Consortium, Science 344, 380-386 (2014)), as well as an in-depth mass spectrometric analysis of the most important neuropeptidergic tissues of this medically and economically important insect species. Mass spectrometric confirmation of predicted peptides is a vital step in the functional characterization of neuropeptides, as in vivo peptides can be modified, cleaved, or even mispredicted. Using a nanoscale reversed phase liquid chromatography coupled to a Q Exactive Orbitrap mass spectrometer, we detected 51 putative bioactive neuropeptides encoded by 19 precursors: adipokinetic hormone (AKH) I and II, allatostatin A and B, capability/ pyrokinin (capa/PK), corazonin, calcitonin-like diuretic hormone (CT/DH), FMRFamide, hugin, leucokinin, myosuppressin, natalisin, neuropeptide-like precursor (NPLP) 1, orcokinin, pigment dispersing factor (PDF), RYamide, SIFamide, short neuropeptide F (sNPF) and tachykinin. In addition, propeptides, truncated and spacer peptides derived from seven additional precursors were found, and include the precursors of allatostatin C, crustacean cardioactive peptide, corticotropin releasing factor-like diuretic hormone (CRF/DH), ecdysis triggering hormone (ETH), ion transport peptide (ITP), neuropeptide F, and proctolin, respectively. The majority of the identified neuropeptides are present in the central nervous system, with only a limited number of peptides in the corpora cardiaca-corpora allata and midgut. Owing to the large number of identified peptides, this study can be used as a reference for comparative studies in other insects.

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Section: Pigment Dispersing Factorsupporting

confidence: 89%

“…It is well known as an important regulator of the insect circadian clock and has been associated with several other processes like activity, reproduction, and geotactic behavior (reviewed in [99]). More recently, PDF has also been associated with ecdysteroid biosynthesis, pheromone production and mating behavior [100,101].…”

Section: Pigment Dispersing Factormentioning

confidence: 99%

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Caers

Boonen

Abbeele³

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…TSA dataset, this despite the fact that members of the PDH family are broadly conserved in both crustaceans and other hexapods (e.g. Meelkop et al, 2011). Here, the most likely explanation for our lack of identification is that the transcript(s) encoding PDH is simply not among those in the existing assembly, though this hypothesis can only be addressed with additional sequence data.…”

Section: The Peptide Precursors and Hormones Of Acerentomon Sp Exhibmentioning

confidence: 81%

Identification of the first neuropeptides from the enigmatic hexapod order Protura

Christie

Chi

2015

General and Comparative Endocrinology

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“…The Journal of Experimental Biology (2014) posterior dorsal edge of the lamina (PDFLad) and a cluster at the posterior ventral edge of the lamina (PDFLav) (Meelkop et al, 2011). In the optic lobe of R. pedestris, only the PDFMe cluster was found, as is the case in some insects, such as the larvae of Rhodnius prolixus and the honeybee Apis mellifera (Vafopoulou et al, 2010;Sumiyoshi et al, 2011).…”

Section: Research Articlementioning

confidence: 99%

The involvement of the brain region containing pigment-dispersing factor-immunoreactive neurons in the photoperiodic response of the bean bugRiptortus pedestris

Ikeno

Numata

Goto

et al. 2013

Journal of Experimental Biology

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The concept of insect photoperiodism based on a circadian clock has been supported by many studies demonstrating that the behavioural circadian rhythm and the photoperiodic response are driven by the same circadian clock genes. However, the neuronal mechanism of the circadian clock underlying photoperiodism is poorly understood. To examine whether circadian rhythm and photoperiodism share a neuronal mechanism, we focused on the neurons that express neuropeptide pigment-dispersing factor (PDF) in the bean bug, Riptortus pedestris. PDF has been identified as an important regulator of the insect circadian rhythm and is expressed in circadian clock neurons of various insect species. In R. pedestris, PDF immunoreactivity was detected in some clusters of cells and their fibres in the optic lobe and the protocerebrum. cDNA encoding a PDF precursor protein was highly conserved between R. pedestris and many other insects. Differences between day and night were not observed in the immunolabelling intensity in cell bodies of PDFimmunoreactive neurons and pdf mRNA expression levels in the head. Surgical removal of the region containing PDF-immunoreactive cell bodies at the medulla disrupted the photoperiodic regulation of diapause. However, gene suppression of pdf by RNA interference did not affect the photoperiodic response. These results suggest that the region containing PDF-immunoreactive somata is important for the photoperiodic response in R. pedestris, but pdf mRNA expression is probably not required for the response.

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Signalling through pigment dispersing hormone-like peptides in invertebrates

Cited by 52 publications

References 231 publications

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Identification of the first neuropeptides from the enigmatic hexapod order Protura

The involvement of the brain region containing pigment-dispersing factor-immunoreactive neurons in the photoperiodic response of the bean bugRiptortus pedestris

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