Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue

Gomes‐Alves, Patrícia; Neves, Sofia; Penque, Deborah

doi:10.1016/b978-0-12-385928-0.00013-4

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…The quality control is determined by crucial interactions either in the early secretory pathway at the ER or in the late secretory pathway at the Golgi, PM, and endosomes after CFTR has folded and exited the ER. Along the secretory pathway, many components of the proteostasis machineries interact with CFTR, regulating its folding, stabilization, or degradation and ultimately its functional protein levels [11][12][13][14][15][16][17][18].…”

Section: Interactions That Govern Cftr Folding Processing and Stabilitymentioning

confidence: 99%

Revisiting CFTR Interactions: Old Partners and New Players

Farinha

Gentzsch

2021

IJMS

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Remarkable progress in CFTR research has led to the therapeutic development of modulators that rescue the basic defect in cystic fibrosis. There is continuous interest in studying CFTR molecular disease mechanisms as not all cystic fibrosis patients have a therapeutic option available. Addressing the basis of the problem by comprehensively understanding the critical molecular associations of CFTR interactions remains key. With the availability of CFTR modulators, there is interest in comprehending which interactions are critical to rescue CFTR and which are altered by modulators or CFTR mutations. Here, the current knowledge on interactions that govern CFTR folding, processing, and stability is summarized. Furthermore, we describe protein complexes and signal pathways that modulate the CFTR function. Primary epithelial cells display a spatial control of the CFTR interactions and have become a common system for preclinical and personalized medicine studies. Strikingly, the novel roles of CFTR in development and differentiation have been recently uncovered and it has been revealed that specific CFTR gene interactions also play an important role in transcriptional regulation. For a comprehensive understanding of the molecular environment of CFTR, it is important to consider CFTR mutation-dependent interactions as well as factors affecting the CFTR interactome on the cell type, tissue-specific, and transcriptional levels.

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Section: Interactions That Govern Cftr Folding Processing and Stabilitymentioning

confidence: 99%

Revisiting CFTR Interactions: Old Partners and New Players

Farinha

Gentzsch

2021

IJMS

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“…The proteomic approaches, namely two-dimensional electrophoresis (2DE), mass spectrometry (MS), and bioinformatics tools used in our recent studies to gain insight into the proteins potentially involved in low-temperature or mutagenic treatment-induced rescue process of F508del-CFTR [31]. The various statistical methods and models for bridging omics data levels have been described [33] from the fields of Machine Learning and Pattern Recognition with particular focus on transcriptomics and proteomics profiles.…”

Section: Recent Developments In Proteomicsmentioning

confidence: 99%

Integration of Bioinformatics Tools for Proteomics Research

Nanda¹,

Tripathy²

2011

J Comput Sci Syst Biol

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An emerging field for the analysis of biological systems is the study of the complete protein complement of the genome, the 'proteome'. Proteomics is defined as a scientific approach used to elucidate all protein species within a cell or tissue. Emerging proteomic technologies have promised for early diagnosis and in advancing treatment directions. Application of these technologies has produced new biomarkers, diagnostic approaches, and understanding of disease biology. Here in this review we have outlined potential implications for clinical proteomics focused on applied research activities. This review presents a general survey of the recent development in array technologies from a proteomics perspective. The significance of informatics in proteomics will gradually increase because of the advent of high-throughput methods relying on powerful data analysis. Lastly, an attempt has been made to present novel biological entities named the bioinformatics tools developed to analyse the large proteinprotein interaction networks they form, along with several new perspectives of the field. Bioinformatics is an integral part of proteomics research.

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Protein Conformational Dynamics and Signaling in Evolution and Pathophysiology

Schweizer

Mueller

2014

Biased Signaling in Physiology, Pharmacology and Therapeutics

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Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue

Cited by 3 publications

References 29 publications

Revisiting CFTR Interactions: Old Partners and New Players

Revisiting CFTR Interactions: Old Partners and New Players

Integration of Bioinformatics Tools for Proteomics Research

Protein Conformational Dynamics and Signaling in Evolution and Pathophysiology

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