Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle

Ursolic acid and luteolin‐7‐glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase‐3

“…Moreover, in colon cancer cells, the fl avonoids luteolin and quercetin, as well as the triterpenoid UA, inhibited the PI3K/Akt pathway (Xavier et al, 2009). On the other hand, kaempferol-3-neohesperidoside stimulates glycogen synthesis in rat soleus muscle, possibly through PI3K/GSK3 pathway (Cazarolli et al, 2009). As well, epigallocatechin-gallate showed stimulatory effects on insulin pathway inhibiting gluconeogenesis and GSK3 activity in hepatocytes through the activation of PI3K/Akt-dependent pathway (Waltner-Law et al, 2002;Lin and Lin, 2008).…”

Plants used as antidiabetics in popular medicine in Rio Grande do Sul, southern Brazil

“…Popular names such as "insulin" and "vegetal insulin" were repeatedly mentioned, for four species of two different families: Aspilia montevidensis and Sphagneticola trilobata (Asteraceae); and Tea, flower dust Garlet and Irgang (2001) Antihyperglycemic activity of the extract by simulation of secretion via pancreatic islets (Hsu et al, 2009); butanol fraction showed potential to prevent Th1-mediated diabetes but promoted Th2-mediated inflammation (Chang et al, 2004(Chang et al, , 2005; water ethanol extracts reduced the hyperglycemia in mildly diabetic mice (Alarcon-Aguilar et al, 2002); The aqueous alcohol extract of the aerial parts showed hypoglicemic activity attributed to polyacetylenic glucosides (Ubillas et al, 2000) Whole (2001) Antioxidant activity related to antidiabetic activity (Souza et al, 2009;Khalil et al, 2008); kaempferol-3-neohesperidoside showed mimetic effect like insulin (Cazarolli et al, 2009b); absence of antidiabetic activity (Volpato et al, 2008); antidiabetic effect attributed to kaempferitrin (Jorge et al, 2004); for review (Cechinel, 2009) (Schoenfelder et al, 2010); aqueous leaf extracts showed hypoglicemic activity in hyperglycemic patients (Bopp et al, 2009); hypoglicemic activity attributed to cuminoside from seeds (Farswan et al, 2009); hypoglycemic activity of mycaminose extracted from seed (Kumar et al, 2008); ethanolic extract of seeds showed hypoglicemic activity in rats (Singh and Gupta, 2007) absence of antihyperglycemic effect of tea and extracts prepared from leaves in normal rats, rats with streptozotocin-induced diabetes, normal volunteers and patients with diabetes ; in vitro glucose uptake activity (Anandharajan et al, 2006); aqueous extract decreased the blood glucose in normal and diabetic rats (Rafiullah et al, 2006); dried bark extract showed antihyperglycemic and hypoglicemic activities (Villaseñor and Lamadrid, 2006); tea prepared from leaves of S. cumini do not showed hypoglycemic effect in patients with type 2 diabetes mellitus ; extract do not reduced the glycemia in diabetic mice the tea and extracts prepared from leaves are pharmacologically inert in diabetic patients (Teixeira et al, 2004); the treatment with tea prepared from leaves did not produce any antihyperglycemic effect in young volunteers neither the crude extract prepared from leaves in diabetic or non-diabetic rats (T...…”

Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil

“…Flavonoids, free and glycosylated, especially kaempferolic glycosides and quercetins account for the main constituents of Bauhinia forficata (Cunha et al, 2010;Marques et al, 2013). The mimetic effect like insulin of Kaempferol-3-neohesperidoside has been shown in both in vitro and in vivo studies (Cazarolli et al, 2009). In addition, the promising hypoglycemic properties of kaempferitrin have also beenreported (Trojan- .…”