Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Vaghari‐Tabari, Mostafa; Qujeq, Durdi; Andevari, Ali Nosrati; Sabahi, Zahra; Moein, Soheila

doi:10.1002/jcp.30276

Cited by 35 publications

(12 citation statements)

References 248 publications

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“…Various studies have shown that some signaling pathways can be targeted using CRISPR/Cas9 technology and can lead to attenuation of drug resistance in cancer cells. One of the most important of these pathways is the PI3K/AKT signaling pathway, which is involved in enhancing proliferation, attenuating apoptosis, and enhancing drug resistance [129,130]. In one study, genes encoding PI3K-110α and PI3K-110β (Pik3ca and Pik3cb) were targeted and knocked out using the CRISPR/Cas9 system.…”

Section: Crispr/cas9 Gene Editing Applications In Overcoming Drug Res...mentioning

confidence: 99%

CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

et al. 2022

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The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, including cancers, by the CRISPR/Cas9 system. In fact, CRISPR/Cas9 gene editing is one of the most efficient genome manipulation techniques. Studies have shown that CRISPR/Cas9 technology, in addition to having the potential to be used as a new therapeutic approach in the treatment of cancers, can also be used to enhance the effectiveness of existing treatments. Undoubtedly, the issue of drug resistance is one of the main obstacles in the treatment of cancers. Cancer cells resist anticancer drugs by a variety of mechanisms, such as enhancing anticancer drugs efflux, enhancing DNA repair, enhancing stemness, and attenuating apoptosis. Mutations in some proteins of different cellular signaling pathways are associated with these events and drug resistance. Recent studies have shown that the CRISPR/Cas9 technique can be used to target important genes involved in these mechanisms, thereby increasing the effectiveness of anticancer drugs. In this review article, studies related to the applications of this technique in overcoming drug resistance in cancer cells will be reviewed. In addition, we will give a brief overview of the limitations of the CRISP/Cas9 gene-editing technique.

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Section: Crispr/cas9 Gene Editing Applications In Overcoming Drug Res...mentioning

confidence: 99%

CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

et al. 2022

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“…Active PI3K activates a secondary messenger called PIP3 with phosphorylation of membrane lipids, and this is PIP3 that activates AKT. AKT enhances cell survival, inhibits apoptosis and also increases cell proliferation [ 116 , 117 ].…”

Section: From Ibd To Cancermentioning

confidence: 99%

From inflammatory bowel disease to colorectal cancer: what’s the role of miRNAs?

et al. 2022

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Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; however, the most important is the increased risk of colorectal cancer, especially in patients with Ulcerative colitis. This risk is increased with increasing the duration of disease, thus preventing the progression of IBD to cancer is very important. Therefore, it is necessary to know the details of events contributed to the progression of IBD to cancer. In recent years, the importance of miRNAs as small molecules with 20–22 nucleotides has been recognized in pathophysiology of many diseases, in which IBD and colorectal cancer have not been excluded. As a result, the effectiveness of these small molecules as therapeutic target is hopefully confirmed. This paper has reviewed the related studies and findings about the role of miRNAs in the course of events that promote the progression of IBD to colorectal carcinoma, as well as a review about the effectiveness of some of these miRNAs as therapeutic targets.

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“…Furthermore, the amount of G6PD and TKT enzymes is elevated in colorectal cancer and hepatocellular carcinoma patient tissues compared to normal counterparts [40,42]. Thus, exploiting the reprogrammed metabolism in tumor cells may offer novel therapeutic targets against cancer [9,43]. We will next cover the use of PPP inhibitors as a therapeutic window in cancer cells.…”

Section: Ppp Impact On Cancer Metabolismmentioning

confidence: 99%

The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities

et al. 2021

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Background: Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions. Unlike their normal cell counterparts, tumor cells rely on aerobic glycolysis, through the Warburg effect. Summary: The pentose phosphate pathway (PPP) is a major glucose metabolic shunt that is upregulated in cancer cells. The PPP comprises an oxidative and a nonoxidative phase and is essential for nucleotide synthesis of rapidly dividing cells. The PPP also generates nicotinamide adenine dinucleotide phosphate, which is required for reductive metabolism and to counteract oxidative stress in tumor cells. This article reviews the regulation of the PPP and discusses inhibitors that target its main pathways. Key Message: Exploiting the metabolic vulnerability of the PPP offers potential novel therapeutic opportunities and improves patients’ response to cancer therapy.

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Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Cited by 35 publications

References 248 publications

CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

From inflammatory bowel disease to colorectal cancer: what’s the role of miRNAs?

The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities

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