Signal transduction pathways regulating Drosophila ovarian germline stem cells

Zhang, Heng; Cai, Yu

doi:10.1016/j.cois.2019.10.002

Cited by 14 publications

(12 citation statements)

References 53 publications

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“…Drosophila melanogaster female GSCs have been utilized as a powerful model system to study the role of niche signals in the self-renewal and differentiation of stem cells, as it is relatively easy to anatomically visualize and genetically manipulate GSCs and their niche ( Ables and Drummond-Barbosa, 2010 ; Greenspan et al, 2015 ; Hayashi et al, 2020 ; Hinnant et al, 2020 ; Lin and Hsu, 2020 ; Zhang and Cai, 2020 ). Female D. melanogaster has a pair of ovaries, each of which is composed of approximately 16 ovarioles.…”

Section: Female Germline Stem Cells In Drosophila Melanogastermentioning

confidence: 99%

“…The niche is usually composed of somatic cells and an extracellular matrix. D. melanogaster GSCs maintain their stemness by receiving juxtacrine and/or paracrine factors derived from the niche, such as Decapentaplegic (Dpp), Wnts, Hedgehog, Unpaired, and possibly Netrin ( Hayashi et al, 2020 ; Zhang and Cai, 2020 ; Tu et al, 2021 ; Yatsenko and Shcherbata, 2021 ). Although many studies have reported that the niche signals are critical in regulating the proliferation and maintenance of GSCs, whether and how the number of GSCs is regulated by the external cues, such as mating, remains elusive.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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In many insect species, mating stimuli can lead to changes in various behavioral and physiological responses, including feeding, mating refusal, egg-laying behavior, energy demand, and organ remodeling, which are collectively known as the post-mating response. Recently, an increase in germline stem cells (GSCs) has been identified as a new post-mating response in both males and females of the fruit fly, Drosophila melanogaster. We have extensively studied mating-induced increase in female GSCs of D. melanogaster at the molecular, cellular, and systemic levels. After mating, the male seminal fluid peptide [e.g. sex peptide (SP)] is transferred to the female uterus. This is followed by binding to the sex peptide receptor (SPR), which evokes post-mating responses, including increase in number of female GSCs. Downstream of SP-SPR signaling, the following three hormones and neurotransmitters have been found to act on female GSC niche cells to regulate mating-induced increase in female GSCs: (1) neuropeptide F, a peptide hormone produced in enteroendocrine cells; (2) octopamine, a monoaminergic neurotransmitter synthesized in ovary-projecting neurons; and (3) ecdysone, a steroid hormone produced in ovarian follicular cells. These humoral factors are secreted from each organ and are received by ovarian somatic cells and regulate the strength of niche signaling in female GSCs. This review provides an overview of the latest findings on the inter-organ relationship to regulate mating-induced female GSC increase in D. melanogaster as a model. We also discuss the remaining issues that should be addressed in the future.

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Section: Female Germline Stem Cells In Drosophila Melanogastermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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“…Maintenance of the GSC homeostasis requires the cooperation of different somatic cell types in the stem cell niche. An interesting example on how disruption of interactions among different somatic cell groups in the germarium leads to germline tumors involves the histone lysine-specific demethylase 1 ( Lsd1 ) null mutation ( Eliazer et al, 2011 ; H. Zhang & Cai, 2020 ). Lsd1 functions specifically within the escort cells to prevent adjacent cap cells from ectopically producing niche-specific BMPs.…”

Section: Tumor Models In Different Tissuesmentioning

confidence: 99%

Tumor models in various Drosophila tissues

Gong

Zhang

Tian

et al. 2021

WIREs Mechanisms of Disease

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The development of cancer is a complex multistage process. Over the past few decades, the model organism Drosophila melanogaster has been crucial in identifying cancer‐related genes and pathways and elucidating mechanisms underlying growth regulation in development. Investigations using Drosophila has yielded new insights into the molecular mechanisms involved in tumor initiation and progression. In this review, we describe various tumor models that have been developed in recent years using different Drosophila tissues, such as the imaginal tissue, the neural tissue, the gut, the ovary, and hematopoietic cells. We discuss underlying genetic alterations, cancer‐like characteristics, as well as similarities and key differences among these models. We also discuss how disruptions in stem cell division and differentiation result in tumor formation in diverse tissues, and highlight new concepts developed using the fly model to understand context‐dependent tumorigenesis. We further discuss the progress made in Drosophila to explore tumor–host interactions that involve the innate immune response to tumor growth and the cachexia wasting phenotype. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics Cancer > Stem Cells and Development Cancer > Molecular and Cellular Physiology

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“…GSC niche produces and secretes several local niche signals that regulate the balance between GSC self-renewal and differentiation ( Hayashi et al, 2020 ; Kirilly and Xie, 2007 ; Spradling et al, 2011 ). For example, bone morphogenetic protein (BMP) ligands Decapentaplegic (Dpp) and Glass bottom boat (Gbb) are produced from the niche cells and directly activate BMP receptors in GSCs, leading to the repression of the differentiation inducer, bag-of-marbles ( bam ) ( Morrison and Spradling, 2008 ; Zhang and Cai, 2020 ). Recent D. melanogaster GSC studies have also contributed to understanding of the systemic regulation of stem cell proliferation and maintenance in response to external environmental cues ( Ables and Drummond-Barbosa, 2017 ; Drummond-Barbosa, 2019 ; Lin and Hsu, 2020 ; Yoshinari et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

Yoshinari

Ameku

Kondo

et al. 2020

eLife

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Stem cells fuel the development and maintenance of tissues. Many studies have addressed how local signals from neighboring niche cells regulate stem cell identity and their proliferative potential. However, the regulation of stem cells by tissue-extrinsic signals in response to environmental cues remains poorly understood. Here we report that efferent octopaminergic neurons projecting to the ovary are essential for germline stem cell (GSC) increase in response to mating in female Drosophila. The neuronal activity of the octopaminergic neurons is required for mating-induced GSC increase as they relay the mating signal from sex peptide receptor-positive cholinergic neurons. Octopamine and its receptor Oamb are also required for mating-induced GSC increase via intracellular Ca2+ signaling. Moreover, we identified Matrix metalloproteinase-2 as a downstream component of the octopamine-Ca2+ signaling to induce GSC increase. Our study provides a mechanism describing how neuronal system couples stem cell behavior to environmental cues through stem cell niche signaling.

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Signal transduction pathways regulating Drosophila ovarian germline stem cells

Cited by 14 publications

References 53 publications

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Tumor models in various Drosophila tissues

Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

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