Tumor models in various <i>Drosophila</i> tissues

Gong, Shangyu; Zhang, Yichi; Tian, Aiqin; Deng, Wu-Min

doi:10.1002/wsbm.1525

Cited by 16 publications

(9 citation statements)

References 153 publications

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“…Since our results described inhere, and those from other labs (Narbonne-Reveau and Maurange, 2019) indicate that chinmo and Br-C have antagonistic effects in terms of proliferation vs. differentiation, we addressed whether these opposite features might also be associated with pro-oncogenic or tumour suppressor properties, respectively. To test this notion, we resorted to the well-defined tumorigenesis model in Drosophila generated by the depletion of cell polarity genes such as lgl (Froldi et al, 2008; Gong et al, 2021). To suppress lgl and create an oncogenic sensitised background (Figure 8A, B and G), we used two UASlgl RNAi constructs recombined on the third chromosome to drive their expression by nubbinGal4 ( nubGal4 ) in the imaginal wing disc pouch.…”

Section: Resultsmentioning

confidence: 99%

Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

Chafino

Giannios

Casanova

et al. 2022

Preprint

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During development, the growing organism transits through a series of temporally regulated morphological stages to generate the adult form. In humans, for example, development progresses from childhood through to puberty and then to adulthood, when sexual maturity is attained. Similarly, in holometabolous insects, immature juveniles transit to the adult form through an intermediate pupal stage when larval tissues are eliminated and the imaginal progenitor cells form the adult structures. The identity of the larval, pupal and adult stages depends on the sequential expression of the transcription factors chinmo, Br-C and E93. However, how these transcription factors determine temporal identity in developing tissues is poorly understood. Here we report on the role of the larval specifier chinmo in larval and adult progenitor cells during fly development. Interestingly, chinmo promotes growth in larval and imaginal tissues in a Br-C-independent and -dependent manner, respectively. In addition, we found that the absence of chinmo during metamorphosis is critical for proper adult differentiation. Importantly, we also provide evidence that, in contrast to the well-known role of chinmo as a pro-oncogene, Br-C and E93 act as tumour suppressors. Finally, we reveal that the function of chinmo as a juvenile specifier is conserved in hemimetabolous insects as its homolog has a similar role in Blatella germanica. Taken together, our results suggest that the sequential expression of the transcription factors Chinmo, Br-C and E93 during larva, pupa an adult respectively, coordinate the formation of the different organs that constitute the adut organism.

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Section: Resultsmentioning

confidence: 99%

Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

Chafino

Giannios

Casanova

et al. 2022

Preprint

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“…Cancer has been described as a wound that does not heal, and there are notable similarities between the mechanisms that stimulate growth in regenerating wing discs and wing discs with mutations in neoplastic tumor suppressor genes ( Mirzoyan et al 2019 ; Gong et al 2021 ). Many neoplastic tumor suppressor mutations disrupt epithelial cell polarity, which triggers activation of responses that parallel those that occur during regeneration, including activation of Jnk, activation of Yki, and activation of Jak-Stat signaling.…”

Section: Regeneration Of the Wing Discmentioning

confidence: 99%

The wing imaginal disc

Tripathi

Irvine

2022

Genetics

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The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of the wing and most of the notum of the adult fly. The wing disc first forms during embryogenesis from a cluster of ∼30 cells located in the second thoracic segment, which invaginate to form a sac-like structure. They undergo extensive proliferation during larval stages to form a mature larval wing disc of ∼35,000 cells. During this time, distinct cell fates are assigned to different regions, and the wing disc develops a complex morphology. Finally, during pupal stages the wing disc undergoes morphogenetic processes and then differentiates to form the adult wing and notum. While the bulk of the wing disc comprises epithelial cells, it also includes neurons and glia, and is associated with tracheal cells and muscle precursor cells. The relative simplicity and accessibility of the wing disc, combined with the wealth of genetic tools available in Drosophila, have combined to make it a premier system for identifying genes and deciphering systems that play crucial roles in animal development. Studies in wing imaginal discs have made key contributions to many areas of biology, including tissue patterning, signal transduction, growth control, regeneration, planar cell polarity, morphogenesis, and tissue mechanics.

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“…On a similar note, several studies present Drosophila as a model insect in the field of oncology [ 9 , 10 , 11 , 12 ]. In cancer research, flies have been crucial to the discovery of genes and pathways that play oncogenic roles [ 13 , 14 , 15 ].…”

Section: Drosophila Melanogaster : a Case Study Of The Innat...mentioning

confidence: 99%

Dynamic Regulation of NF-κB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila

Cammarata-Mouchtouris

Acker

Goto

et al. 2022

Biomedicines

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Metazoans have developed strategies to protect themselves from pathogenic attack. These preserved mechanisms constitute the immune system, composed of innate and adaptive responses. Among the two kinds, the innate immune system involves the activation of a fast response. NF-κB signaling pathways are activated during infections and lead to the expression of timely-controlled immune response genes. However, activation of NF-κB pathways can be deleterious when uncontrolled. Their regulation is necessary to prevent the development of inflammatory diseases or cancers. The similarity of the NF-κB pathways mediating immune mechanisms in insects and mammals makes Drosophila melanogaster a suitable model for studying the innate immune response and learning general mechanisms that are also relevant for humans. In this review, we summarize what is known about the dynamic regulation of the central NF-κB-pathways and go into detail on the molecular level of the IMD pathway. We report on the role of the nuclear protein Akirin in the regulation of the NF-κB Relish immune response. The use of the Drosophila model allows the understanding of the fine-tuned regulation of this central NF-κB pathway.

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Tumor models in various Drosophila tissues

Cited by 16 publications

References 153 publications

Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

The wing imaginal disc

Dynamic Regulation of NF-κB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila

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