Signal intensity changes of the fetal liver on MRI in‐phase and out‐of‐phase sequence

Li, Xiaobing; Brugger, Peter C.; Huang, Min; Kasprian, Gregor; Li, Hong; Bettelheim, Dieter; Prayer, Daniela

doi:10.1002/pd.4075

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…The ideal conditions of reference structures are sufficient size, close position to the lung, homogeneity and stability through the pregnancy. Although fetal liver signal intensity may change through pregnancy, the liver satisfies almost all these conditions. The relation between LLSIR and gestational age has already been studied …”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of fetal respiratory function: evaluation of fetal lung maturity using lung‐to‐liver signal intensity ratio at magnetic resonance imaging

et al. 2014

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ObjectiveThe purpose of this retrospective study is to determine the fetal lung-to-liver signal intensity ratio (LLSIR) on T2-weighted images for the prediction of neonatal respiratory outcome.MethodsOne hundred ten fetuses who underwent magnetic resonance imaging (MRI) examination for various indications after 22 weeks of gestation participated in this study. LLSIR was measured as the ratio of signal intensities of the fetal lung and liver on T2-weighted images at MRI. We examined the changes of the ratio with advancing gestation and the relations between LLSIR and the presence of the severe respiratory disorder (SRD) after birth. The best cut-off value of the LLSIR to predict respiratory outcome after birth was calculated using receiver operating characteristic (ROC) curve analysis.ResultsLung-to-liver signal intensity ratio correlated significantly with advancing gestational age (R = 0.35, p < 0.001). The non-SRD group had higher LLSIR compared with the SRD group (2.15 ± 0.30 vs. 1.53 ± 0.40, p < 0.001). ROC curve analysis showed that fetuses with an LLSIR < 2.00 were more likely to develop SRD [sensitivity: 100%, 95% confidence interval (CI): 52–100%; specificity: 73%, 95% CI 54–88%].ConclusionThe fetal LLSIR on T2-weighted images is an accurate marker to diagnose the fetal lung maturity. © 2014 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of fetal respiratory function: evaluation of fetal lung maturity using lung‐to‐liver signal intensity ratio at magnetic resonance imaging

et al. 2014

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Section: Fetal Spleenmentioning

confidence: 99%

“…Anatomical variations in the fetal spleen demonstrated on MRI have been commented on in relation to lymphatic malformations and situs anomalies 65,66 ; it has also been used as a reference for signal intensity differences in the fetal liver. 67 Functional properties using T2* weighted imaging have been utilised in fetal animal models and human neonates with an aim to antenatal diagnosis of haemochomatosis. 68 Given that the changes described are primarily histological rather than associated with changes in mass, the application of diffusion weighted MRI for better understanding of functional properties of the fetal spleen may be merited.…”

Section: Details Of View Requiredmentioning

confidence: 99%

Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging

et al. 2022

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Chorioamnionitis is present in up to 70% of spontaneous preterm births. It is defined as an acute inflammation of the chorion, with or without involvement of the amnion, and is evidence of a maternal immunological response to infection. A fetal inflammatory response can coexist and is diagnosed on placental histopathology postnatally. Fetal inflammatory response syndrome (FIRS) is associated with poorer fetal and neonatal outcomes. The only antenatal diagnostic test is amniocentesis which carries risks of miscarriage or preterm birth. Imaging of the fetal immune system, in particular the thymus and the spleen, and the placenta may give valuable information antenatally regarding the diagnosis of fetal inflammatory response.While ultrasound is largely limited to structural information, MRI can complement this with functional information that may provide insight into the metabolic activities of the fetal immune system and placenta. This review discusses fetal and placental imaging in pregnancies complicated by chorioamnionitis and their potential future use in achieving non-invasive antenatal diagnosis. Key points What's already known about the topic?� Chorioamnionitis is present in up to 70% of spontaneous preterm births and is associated with more complications than unaffected spontaneous preterm births � Diagnosis is postnatal. Antenatal diagnosis by amniocentesis carries a risk of preterm birth, and is not integrated into clinical care What does this review add?� Ultrasound assessment of the fetal immune system gives structural information and limited functional information, while MRI can complement this with greater functional tissue information � Imaging may play a role in the non-invasive antenatal diagnosis of chorioamnionitisThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Prenatal Diagnosis by Fetal Magnetic Resonance Imaging

Girard

Chaumoître

2015

Genetic Disorders and the Fetus

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Signal intensity changes of the fetal liver on MRI in‐phase and out‐of‐phase sequence

Cited by 5 publications

References 21 publications

Prenatal diagnosis of fetal respiratory function: evaluation of fetal lung maturity using lung‐to‐liver signal intensity ratio at magnetic resonance imaging

Prenatal diagnosis of fetal respiratory function: evaluation of fetal lung maturity using lung‐to‐liver signal intensity ratio at magnetic resonance imaging

Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging

Prenatal Diagnosis by Fetal Magnetic Resonance Imaging

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