Signal enhancement of carboxylic acids by inclusion with β‐cyclodextrin in negative high‐voltage‐assisted laser desorption ionization mass spectrometry

Abstract

The negative HALDI-MS S/Ns of carboxylic acids can be improved up to 30 times via forming non-covalent complexes with β-CD. The developed method shows the advantages of being rapid and simple, and is promising for rapid detection of active ingredients in complex samples or fast screening of drugs and cosmetics.

Quantitative analysis of biogenic polyamines in distilled drinks by direct electrospray ionization tandem mass spectrometry using a nanocontainer

“…However, if the host‐guest binding is selective and supramolecular structures survive the electrospray ionization (ESI) process, leading to stable gas‐phase complexes, the resulting ESI‐MS or ESI‐MS/MS signals can be used for analytical purposes. This concept has been applied to direct injection (infusion) analysis of small molecules using metal phthalocyanins, low molecular weight explosives and carboxylic acids using cyclodextrins, and drugs by following the formation of dimers and clusters …”

“…Direct injection methods show however limitations, mainly in samples having high complexity and containing non‐volatile compounds, such as salts. Extraction and/or fractionating procedures might be necessary before injection . Distilled drinks, such as spirits, contain mostly volatile compounds, making the detection of polyamines in these matrices potentially achievable by ESI‐MS with minimum sample processing.…”

“…[18][19][20] However, if the host-guest binding is selective and supramolecular structures survive the electrospray ionization (ESI) process, leading to stable gas-phase complexes, the resulting ESI-MS or ESI-MS/MS signals can be used for analytical purposes. This concept has been applied to direct injection (infusion) analysis of small molecules using metal phthalocyanins, [21] low molecular weight explosives and carboxylic acids using cyclodextrins, [22,23] and drugs by following the formation of dimers [24] and clusters. [25][26][27] The measured ion abundances under ESI-MS depend on several factors, including the analyte concentration, affinity to droplet surface and conformation, solution chemistry and transmission and detection conditions.…”

“…Extraction and/or fractionating procedures might be necessary before injection. [21][22][23][24][25][26][27][32][33][34][35] Distilled drinks, such as spirits, contain mostly volatile compounds, making the detection of polyamines in these matrices potentially achievable by ESI-MS with minimum sample processing. Although polyamines can be readily seen in the gas phase under positive polarity, their low molecular weight makes the quantification quite difficult.…”

Mass and Charge Measurements on Heavy Ions

“… 2 , 18 ) HALDI can control the polarity of the product ions simply by the voltage. 45 , 46 ) Another advantage of HALDI is that no matrix is used, which leads to signals without contaminating ions from the matrix. 45 )…”