Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo

Iyengar, Smriti; Mick, Steve J.; Dilworth, Vickie M.; Michel, Joachim; Rao, Tadimeti S.; Farah, John M.; Wood, Paul L.

doi:10.1016/0028-3908(90)90017-l

Cited by 63 publications

(26 citation statements)

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“…In addition, the σ-receptor-mediated modulation of the HPA axis has been demonstrated to be mimicked by steroids, since (+)SKF-10,047 and (+)pentazocine increase, as did progesterone (after estrogen priming), testosterone and desoxycorticosterone, whereas (+)3-PPP and (−)butaclamol decrease prolactin release (90,91). This was however not the case in vitro for corticotrophin-releasing-factor-evoked adrenocorticotropic hormone release from primary culture cells of the anterior pituitary (90,92).…”

Section: Steroids and Neurosteroids Bind Both σ 1 And σ 2 Sites In Pementioning

confidence: 99%

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

2006

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Abstract. Steroids synthesized in the periphery or de novo in the brain, so called 'neurosteroids', exert both genomic and nongenomic actions on neurotransmission systems. Through rapid modulatory effects on neurotransmitter receptors, they influence inhibitory and excitatory neurotransmission. In particular, progesterone derivatives like 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) are positive allosteric modulators of the γ-aminobutyric acid type A (GABA A ) receptor and therefore act as inhibitory steroids, while pregnenolone sulphate (PREGS) and dehydroepiandrosterone sulphate (DHEAS) are negative modulators of the GABA A receptor and positive modulators of the N-methyl-D-aspartate (NMDA) receptor, therefore acting as excitatory neurosteroids. Some steroids also interact with atypical proteins, the sigma (σ) receptors. Recent studies particularly demonstrated that the σ 1 receptor contributes effectively to their pharmacological actions. The present article will review the data demonstrating that the σ 1 receptor binds neurosteroids in physiological conditions. The physiological relevance of this interaction will be analyzed and the impact on physiopathological outcomes in memory and drug addiction will be illustrated. We will particularly highlight, first, the importance of the σ 1 -receptor activation by PREGS and DHEAS which may contribute to their modulatory effect on calcium homeostasis and, second, the importance of the steroid tonus in the pharmacological development of selective σ 1 drugs.

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Section: Steroids and Neurosteroids Bind Both σ 1 And σ 2 Sites In Pementioning

confidence: 99%

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

2006

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“…It is now clear that the synthesis of glucocorticoid hormones in the adrenal cortex is under the influence of µ, κ, and σ opioids and N-methyl-d-aspartate (NMDA) glutamatergic receptors (Iyengar et al, 1990). So, inhibition of these receptors may lead to a reduction of corticosterone and cortisol release from the adrenal gland during stress.…”

Section: Research Articlementioning

confidence: 99%

“…In this way, Lechtenberg and colleagues (2008) showed that saffron extract can inhibit NMDA glutamate and sigma opioid receptors in the rat. In addition, some investigators have shown that regulation of opioid receptors plays a key role in regulation of corticosterone release from adrenal gland (Iyengar et al, 1990). It is likely that the extract may inhibit corticosterone release by such mechanism.…”

Section: Behavior Groupsmentioning

confidence: 99%

Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

Hooshmandi

Rohani

Eidi

et al. 2011

Pharmaceutical Biology

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“…In turn, the s 1 receptor may be involved in a tonic negative regulation of the activity of the HPA axis, with antagonists facilitating the corticosterone release into the plasma, while agonists, through an anti-CRF effect, decreasing it. In addition, s 1 receptor agonists, including ( þ )-SKF-10,047, ( þ )-pentazocine, ( þ )-3-[3-hydroxyphenyl-N(1-propyl)piperidine] (( þ )-3PPP) or (À)-butaclamol, stimulate ACTH release after central or peripheral administration (Iyengar et al, 1990;, and thus may mediate an indirect effect on glucocorticoid release from the cortico-adrenals. Consequently, activation of the s 1 receptor may also contribute to the negative feedback action on the HPA axis.…”

Section: J Meunier Et Almentioning

confidence: 99%

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

Meunier

Gué

Récasens

et al. 2004

British J Pharmacology

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1 Stress during pregnancy results in complex neurochemical and behavioral alterations throughout the offspring lifetime. We here examined the impact of prenatal stress (PS) on memory functions in male and female offspring and report the efficacy of a selective sigma 1 (s 1 ) receptor agonist, igmesine, in alleviating the observed deficits. 2 Dams received an unpredictable 90-min duration restraint stress from gestational day E17 to E20. Learning was examined in offspring between day P24 and P36 using spontaneous alternation in the Y-maze, delayed alternation in the T-maze, water-maze learning and passive avoidance. 3 Both male and female PS rats showed impairments of spontaneous and delayed alternation performances. Acquisition of a fixed platform position in the water-maze was unchanged in PS rats, but the probe test revealed a diminution of time spent in the training quadrant. Acquisition of a daily changing platform position demonstrated impaired working memory for male and female PS rats. Finally, passive avoidance deficits were observed. 4 Pretreatment with the selective s 1 agonist igmesine (1-10 mg kg À1 i.p.) reversed the PS-induced learning deficits in offspring rats for each test. The s 1 antagonist BD1063 failed to affect performances alone but blocked the igmesine effect, confirming the involvement of the s 1 receptor. 5 PS thus induces delayed memory deficits, affecting spatial and nonspatial, short-and long-term memories in juvenile male and female offspring rats. Activation of the s 1 neuromodulatory receptor allows a significant recovery of the memory functions in PS rats.

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Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo

Cited by 63 publications

References 3 publications

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

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Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo

Cited by 63 publications

References 3 publications

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats

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Attenuation by a sigma₁ (σ₁) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats