Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

Hooshmandi, Zahra; Rohani, Ali Haeri; Eidi, Akram; Fatahi, Zahra; Golmanesh, Leila; Sahraei, Hedayat

doi:10.3109/13880209.2011.558103

Cited by 44 publications

(35 citation statements)

References 33 publications

(54 reference statements)

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“…The floor of the compartments had steel wires and was connected to the electroshock device, which was controlled by a PC. The severity and duration of electroshock induction were 60 mV, 10 Hz, and for 100 Sec [28]. Animals were placed in the apparatus 30 min before the stress beginning and maintained in the apparatus after stress termination for additional 30 min.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Nasihatkon

Khosravi

Bourbour

et al. 2014

Behavioural Neurology

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Background. Stress and its consequences are among the causes of accidents. Objective. The effects of intraventral tegmental area (I-VTA) memantine on the plasma corticosterone and eating parameters disturbance induced by acute stress were investigated. Methods. Male Wistar rats (W: 250–300 g) were divided into control and experiential groups, each of which received memantine either intra-VTA or peripherally. One week after bilateral cannulation, the rats received memantine (1 and 5 μg/Rat) five min before electroshock stress. The other experimental groups received memantine (1 and 5 mg/kg) intraperitoneally 30 min before stress. The control groups received saline or memantine but did not experience stress. Food and water intake and plasma corticosterone level were recorded. Results. Results showed that stress decreases food intake but does not change water intake and increase in plasma corticosterone level. Intraperitoneal memantine administration slightly inhibits the stress effects on food intake. However, water intake and plasma corticosterone level were increased. Intra-VTA memantine reduces the effects of stress on corticosterone and water intake. Conclusion. It could be concluded that inhibition of glutamate NMDA receptors in the VTA by memantine leads to the inhibition of the eating behavior parameters and plasma corticosterone level disturbance induced by stress in rats.

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Section: Methodsmentioning

confidence: 99%

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Nasihatkon

Khosravi

Bourbour

et al. 2014

Behavioural Neurology

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“…Other volatile oils in saffron are cineole, phenethenol, pinene, borneol, geraniol, limonene, p-cymene, linalool, terpinen-4-oil, etc. [16] Safranal showed anti-oxidant activity and reduced oxidative damages in different organs such as skeletal muscle,[17] kidney,[18] and hippocampus. [19]…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor activity of safranal against neuroblastoma cells

et al. 2014

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Objective:Safranal (2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, C10H14O) is an active ingredient in the saffron, which is used in traditional medicine, and also, the biological activity of saffron in anti-cancer is in development. It has been reported to have anti-oxidant effects, but its anti-tumor effects remain uncertain. The aim of this study was to evaluate effects of safranal on anti-tumor on neuroblastoma cells.Materials and Methods:Neuroblastoma cells were cultured and exposed to safranal (0, 10, 15, 20, 50 μg/ml). Cell proliferation was examined using the 3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Apoptotic cells, cell cycle distribution, and sub-G1 fraction were analyzed using flow cytometric analysis after propidium iodide staining.Results:Safranal inhibited the growth of malignant cells in a dose-and time-dependent manner. The IC (50) values against the neuroblastoma cell line were determined as 11.1 and 23.3 μg/ml after 24 and 48 h, respectively. Safranal induced a sub-G1 peak in the flow cytometry histogram of treated cells compared to control cells indicating that apoptotic cell death is involved in safranal toxicity.Conclusions:Our pre-clinical study demonstrated a neuroblastoma cell line to be highly sensitive to safranal-mediated growth inhibition and apoptotic cell death. Although the molecular mechanisms of safranal action are not yet clearly understood, it appears to have potential as a therapeutic agent.

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“…For example, saffron and its constituents, crocin, crocetin and safranal, are potent antioxidants and can increase antioxidant activity and lower oxidative stress, as demonstrated via animal and in vitro models (Boskabady and Farkhondeh, 2016;Broadhead et al, 2016;Samarghandian et al, 2017). Saffron also has anti-inflammatory properties (Poma et al, 2012) and may modulate HPA activity in animal stress models by reducing levels of plasma corticosterone (Halataei et al, 2011;Hooshmandi et al, 2011). Finally, there is preliminary evidence to suggest that saffron may also influence monoaminergic activity.…”

Section: Discussionmentioning

confidence: 99%

affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study

Lopresti

Drummond

Inarejos-García³

et al. 2018

Journal of Affective Disorders

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Journal of Affective Disorders 232 (2018) However, this is the first study examining its mood-related effects in teenagers. MethodsIn this 8-week, randomised, double-blind, placebo-controlled study, youth aged 12 to 16 years, with mild-to-moderate anxiety or depressive symptoms were given tablets containing placebo or a saffron extract (affron ® , 14mg b.i. d). The youth and parent versions of the Revised ChildAnxiety and Depression Scale (RCADS) were used as outcome measures.Results 80 participants were enrolled and 68 completed the study. Based on youth self-reports, affron ® was associated with greater improvements in overall internalising symptoms (p = .049), separation anxiety (p = .003), social phobia (p = .023), and depression (p = .016). Total internalising scores decreased by an average of 33% compared to 17% in the placebo group (p=.029). However, parental reports of improvements were inconsistent as mean improvements in RCADS scores were greater in the saffron group (40% vs 26%) (p=.026), although no other significant differences were identified. affron ® was well-tolerated and there was a trend of reduced headaches in participants on the active treatment.Limitations: The use of a self-report instrument, limited study duration, single treatment dose, and non-clinical sample used in this study limit the generalisability of study findings. ConclusionThe administration of a standardised saffron extract (affron ® ) for 8 weeks improved anxiety and depressive symptoms in youth with mild-to-moderate symptoms, at least from the perspective of the adolescent. However, these beneficial effects were inconsistently corroborated by parents.

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Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal

Abstract: (2011) Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron water extract and its constituent safranal, Pharmaceutical Biology, 49:9, 947-954,

Cited by 44 publications

References 33 publications

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Inhibitory Effect of NMDA Receptors in the Ventral Tegmental Area on Hormonal and Eating Behavior Responses to Stress in Rats

Anti-tumor activity of safranal against neuroblastoma cells

affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study

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