Sigma-1 receptor stimulation with fluvoxamine activates Akt–eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding

Bhuiyan, Md. Shenuarin; Tagashira, Hideaki; Fukunaga, Kohji

doi:10.1016/j.ejphar.2010.10.055

Cited by 39 publications

(27 citation statements)

References 54 publications

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“…Our data provide strong evidence that up-regulation of FKBP51 mediates DEX-induced autophagy and dephosphorylation of pAkt S473 [60]. Akt, in turn, has been reported previously as a target of antidepressant action, and both positive and negative changes in pAkt S473 levels have been found for different antidepressants in various cellular systems [55],[56],[62],[63]. Treatment duration and other factors may account for the divergent results.…”

Section: Discussionsupporting

confidence: 58%

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

et al. 2014

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Section: Discussionsupporting

confidence: 58%

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

et al. 2014

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“…We also found that fluvoxamine-mediated activation of Akt and eNOS signaling via sigma-1 receptors likely mediates antihypertrophic effects (22,25,28). Interestingly, our studies show that continuous administration of fluvoxamine for 4 weeks not only increases Akt-mediated eNOS phosphorylation on Ser 1177 but also enhances eNOS protein expression in the LV (Fig.…”

Section: Possible Mechanism Of Ssri-mediated Cardioprotectionsupporting

confidence: 49%

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

2013

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Abstract. Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression. Thus, therapy with selective serotonin reuptake inhibitors (SSRIs) is strongly recommended to reduce cardiovascular diseaseinduced morbidity and mortality. However, molecular mechanisms to support evidence-based SSRI treatment of cardiovascular disease have not been elucidated. We recently found very high expression of the sigma-1 receptor, an orphan receptor, in rat heart tissue and defined the cardiac sigma-1 receptor as a direct SSRI target in eliciting cardioprotection in both pressure overload (PO)-induced and transverse aortic constriction (TAC)-induced myocardial hypertrophy models in rodents. Our findings suggest that SSRIs such as fluvoxamine protect against PO-and TACinduced cardiac dysfunction by upregulating sigma-1 receptor expression and stimulating sigma-1 receptor-mediated Akt-eNOS signaling. Here, we discuss the association of depression and cardiovascular diseases, the protective mechanism of SSRIs in heart failure patients, and the pathophysiological relevance of sigma-1 receptors to progression of heart failure. These findings should promote development of clinical therapeutics targeting the sigma-1 receptor in cardiovascular diseases.

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“…24,25 We found that PO-induced cardiac hypertrophy in ovariectomized rats and mice significantly decreases R 1 receptor expression in the left ventricle with concomitant cardiac contractile dysfunction. 16,21,22 Here, we define the cardioprotective actions of DHEA through the R 1 receptor and compare them with the effects of E 2 .…”

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confidence: 97%

Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload–induced hypertrophy in ovariectomized female rats

et al. 2011

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Sigma-1 receptor stimulation with fluvoxamine activates Akt–eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding

Cited by 39 publications

References 54 publications

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

Distinct cardioprotective effects of 17β-estradiol and dehydroepiandrosterone on pressure overload–induced hypertrophy in ovariectomized female rats

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