In this study, the effects of zeolite applied in addition to routine treatment protocols on Na + , K + , and Cllevels in calves with diarrhea were investigated. 1-32 days old twelve calves with diarrhea, and 6 healthy controls brought to Sefa Veterinary Clinic in Viranşehir district were enrolled for the study. The responsible bacteria were Escherichia coli in nine of the diarrhea calves and Criptosporodium parvum, Corona virus and Clostridium perfiringens were in the others. Calves with diarrhea were divided into three groups in equal numbers (n=6) as negative control (healthy animal+1 g/kg day oral zeolite), positive control (routine treatment in animals with diarrhea), zeolite group (routine treatment in animals with diarrhea + zeolite (1g/kg/day, oral)). The application was made according to the prospectuses of İsotonic 0.9% NaCl (Polifleks ® , Polifarma, Turkey), sodium bicarbonate (Bikarvil ® , Vilsan, Ankara), Vitamin, Amino acid, Electrolyte, Dextrose (Duphalyte ® , Zoetis, Spain) + Vitamine C (İnjacom C ® , Ceva, Istanbul) + Marbofloxacin (Marbox ®, Ceva, Istanbul) were administered daily to the positive control and zeolite groups. During the treatment procedure, death was observed on the 6th day in a calf with Corona virus. During the treatment, Na + , K + , and Clions were measured in the serum on the 1st, 3rd, and 5thdays. There was no statistical difference between the groups in terms of Na + and Clions on the 1st, 3rd, and 5th days (p>0.05). However, the 1st and 5th-day K + levels were found to be higher in the zeolite group compared to the other groups (p<0.001). The reason for this difference is thought to be due to both the cellular damage due to diarrheal agents and the increase in K + absorption from the environment by zeolite. However, it was observed that the healing process of diarrhea was faster in the zeolite group compared to the other groups.