Sideritis scardica Griseb., an endemic species of Balkan peninsula: Traditional uses, cultivation, chemical composition, biological activity

Todorova, Milka; Трендафилова, Антоанета

doi:10.1016/j.jep.2014.01.022

Cited by 75 publications

(96 citation statements)

References 28 publications

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“…The TLC analysis revealed similarities in composition between this extract and that obtained with water. The water extraction is in turn closely related to a tea preparation, which is a traditional form of the use of S. scardica [1,2]. …”

Section: Discussionmentioning

confidence: 99%

“…As there were no signs of any toxicity or mortality, three further female animals were added to the study and treated with the same dose (step 2). The applied dosage was selected based on data from the literature and from the knowledge of the phytochemical composition of the test item [1,6,7]. …”

Section: Methodsmentioning

confidence: 99%

“…(Lamiaceae family) is a subalpine/alpine plant species endemic to the central part of the Balkan Peninsula, specifically the northeastern regions of Greece, central and western regions of Macedonia, the southern regions of Bulgaria, and southwest regions of Albania [1,2]. Commonly known as ironwort, it has a long history of collection from the wild and exploitation for its aromatic properties in local cuisines as a flavour or a tea substitute for recreational use (known as mountain tea or shepherd´s tea), otherwise also for the treatment of certain complaints of the respiratory (e.g., asthma, cough, bronchitis, lung emphysema) and gastrointestinal tracts, and for immunomodulating and diuretic action that would yet require clinical evidence.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

Feistel¹,

Wegener²,

Rzymski

et al. 2018

Toxins

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Sideritis scardica Griseb. has a long history of collection from the wild as a traditional remedy for respiratory and gastrointestinal complaints. It has also been investigated for its promising pharmacological activities in the central nervous system. However, its toxicological data is entirely missing. This study investigated the acute and repeated-dose oral toxicity of a S. scardica 20% (v/v) ethanol extract in Sprague Dawley rats, and mutagenicity using the Ames test. No gross pathological abnormalities and no toxicity signs or mortality were detected in animals treated with the dose of 2000 mg/kg bw during 14 days of observation. The tested extract was assigned to category 5 of the GHS. To evaluate a repeated-dose toxicity, an extract has been tested over a 28-day period followed by a 14-day recovery period. No mortality and no changes in body/organ weight or food consumption have been observed. The no-observed-adverse-effect-level of the extract was determined at 1000 mg/kg bw. The results of Ames tests conducted on extracts of different polarity (water; 20% (v/v) ethanol; 50% (v/v) ethanol; n-heptane), were unequivocally negative. The study reveals no toxicity of S. scardica and no concerns for its mutagenic effects, supports its positive safety profile, and confirms the acknowledged traditional medicinal use in human.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

Feistel¹,

Wegener²,

Rzymski

et al. 2018

Toxins

View full text Add to dashboard Cite

show abstract

“…is called çay çalbası [4] and eldiven çayı [5] by local people. Up to now, several biological activities such as antioxidant, anticonvulsant, antispasmodic, anti-inflammatory, anti-rheumatic, antiulcer, antimicrobial, cytotoxic, and analgesic have been reported from Sideritis species [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. Heldr. endemic to Turkey

Deveci¹,

Tel‐Çayan²,

Yıldırım³

et al. 2017

mpj

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The objective of this study was to investigate the chemical composition, antioxidant, anticholinesterase and anti-urease activities of essential oil, hexane, acetone and methanol extracts of Sideritis pisidica Boiss. & Heldr. The essential oil and fatty acid composition were analyzed by GC and GC/MS. δ-Cadinene (19.5 %), T-cadinol (16.7 %) and β-cubebene (10.4 %) were identified as the main compounds of the essential oil whereas the most abundant compounds of fatty acids were found as linolenic (42.7 %), palmitic (31.3 %) and linoleic (13.4%) acids. The methanol extract demonstrated the highest antioxidant activity in all tests, except for metal chelating assay. The hexane extract was found to be significantly active in metal chelating (IC 50 : 22.97±1.36 µg/mL), acetylcholinesterase (62.54±0.88 %) and urease inhibitory (78.93±0.17 %) assays. These results show that the Sideritis pisidica could be used as the potential source of natural products in the food and pharmaceutical areas.

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“…Sideritis scardica (S. scardica) is an endemic species of the Central Balkan Peninsula and its distribution is restricted to Bulgaria, Greece, North Macedonia, Albania, Serbia, and Turkey [1,2]. In Greece, the species is distributed mostly to the North and North-Eastern parts of the country.…”

Section: Introductionmentioning

confidence: 99%

Abundance and Phenotypic Diversity of the Medicinal Sideritis Scardica Griseb. in Relation to Floristic Composition of Its Habitat in Northern Greece

et al. 2020

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Sideritis scardica (S. scardica) is an endemic medicinal species of the Central Balkan Peninsula. The aerial parts are traditionally used in folk medicine and, therefore, have been collected extensively from natural habitats. Overexploitation in combination with climate change has resulted in severely fragmented populations. In this context, the purpose of this study was to access the abundance and phenotypic diversity of S. scardica populations in relation to plant community structure and environmental and anthropogenic factors in six mountainous areas of Northern Greece. For this reason, the floristic composition and diversity was determined by accessing the number of plant species, number of individuals per plant species, and plant cover in each study area. In addition, the soil properties of the studied areas were determined and the phenotypic diversity of S. scardica populations was accessed through the imaging of leaf and inflorescence main characteristics. As a result, 141 plant species were identified in all studied areas, while the floristic composition clearly distinguished the North-Central from the North-Eastern studied areas. S. scardica was the predominant species in the habitats where the presence of forbs was favored, while a high presence of graminoid and shrub species in the study areas depressed its presence. A high coefficient of variations was recorded among the six populations, varying from 12.2%–29.2% and 13.3%–43.1% for inflorescence and leaf traits.

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Sideritis scardica Griseb., an endemic species of Balkan peninsula: Traditional uses, cultivation, chemical composition, biological activity

Cited by 75 publications

References 28 publications

Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. Heldr. endemic to Turkey

Abundance and Phenotypic Diversity of the Medicinal Sideritis Scardica Griseb. in Relation to Floristic Composition of Its Habitat in Northern Greece

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