Side Effects of Chemotherapy among Cancer Patients in a Malaysian General Hospital: Experiences, Perceptions and Informational Needs from Clinical Pharmacists

Chan, Huan‐Keat; Ismail, Sabrina

doi:10.7314/apjcp.2014.15.13.5305

Cited by 130 publications

(106 citation statements)

References 30 publications

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“…This is coincidental to the findings of Chan, et al ., (2014) and Afzal, et al ., (2014) which showed paclitaxel -carboplatin (36.7%) and AC (4.61%) respectively to be the most commonly prescribed chemotherapeutic regimen. 4,5 Among the total chemotherapeutic agents prescribed in our study, cyclophosphamide was the most common agent followed by oxaliplatin, paclitaxel, capecitabine, carboplatin, cisplatin, doxorubicin. This was almost similar to the study conducted by Thennarasu, et al ., which revealed that paclitaxel (36.6%) to be the most commonly prescribed drug followed by capecitabine (27.5%), cyclophosphamide (22.9%), cisplatin (18.30%), doxorubicin (15.5%), carboplatin (13.70%), oxaliplatin (5.50%).…”

Section: Discussionmentioning

confidence: 82%

Assessment of Adverse Effects of Most Commonly Prescribed Anticancer Drugs in a Tertiary Care Teaching Hospital

Sunny¹,

Thampi²,

Johnkennedy³

et al. 2018

IJOPP

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Background: Chemotherapeutic agents account for high inclination towards adverse drug reactions due to its narrow therapeutic window, increased toxicity and highly complex regimen making pharmacovigilance studies essential in oncology. Aim:The aim of the study is to assess the adverse effects of most commonly prescribed anticancer drugs in a tertiary care teaching hospital and to evaluate its causality, severity and preventability. Materials and methods: A prospective observational study was conducted on 200 patients taking chemotherapy in oncology unit. Patient information was obtained using a data collection form and data was collected using a structured questionnaire. Assessment of adverse drug reactions were analyzed using WHO -UMC causalilty assessment scale, Hartwig -Siegel severity assessment scale and modified schumock and thornton preventability scale. Results: Cyclophosphamide (10.62%) was the most commonly prescribed anticancer drug. A total of 450 ADRs were observed from 109 patients. Females (60.55%) were more prone to ADRs than males. The most frequent adverse reaction was vomiting (10%) followed by anaemia (9.11%), alopecia (7.11%), fatigue (6.67%). WHO causality assessment scale showed 45.78% of the reactions to be "possible", 40.44% to be "probable", 12.89% to be "unlikely" and 0.89% to be "certain". Modified Hartwig and Siegel scale showed most reactions, 54.13% to be mild, 44.95% to be moderate and 0.92% to be severe reactions. According to modified Schumock and Thornton scale, 46.22% of the ADRs were "definitely preventable", 20.67% were "probably preventable" and 33.11% were "not preventable". Conclusion: Chemotherapeutic agents are highly associated with adverse reactions. Measures should be undertaken to improve ADR monitoring and reporting, thereby decrease the incidence of ADR, improve patient's quality of life and ensure safe use of drugs.

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Section: Discussionmentioning

confidence: 82%

Assessment of Adverse Effects of Most Commonly Prescribed Anticancer Drugs in a Tertiary Care Teaching Hospital

Sunny¹,

Thampi²,

Johnkennedy³

et al. 2018

IJOPP

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“…Bu gibi semptomların kanserli hastaların yaşam kalitesini olumsuz yönde etkilediği bilinmektedir. [26] Hastalık ve tedavi sürecinde hastaları fiziksel ve psikolojik olarak olumsuz yönde etkileyen, kontrol altına alınmadığında tedavi planında değişikliklere neden olan, ek tedavi ve hastaneye yatış gereksinimi nedeni ile maliyet artışına neden olan semptomların [27][28][29] ve semptom yönetiminin bu alanda hemşireler tarafından yapılan araştırmalarda sık-lıkla ele alınan konular arasında olması ve çözüm önerilerinin sunulması olumlu bir sonuç olarak değerlendirilmektedir. Bu çalışmada yapılan taramalarda incelenen semptomların sıklıkla yorgunluk, uykusuzluk, ağrı ve ansiyete olduğu belirlenmiş-tir.…”

Section: Discussionunclassified

Review of oncology nursing research that conducted by nurses in Turkey and published between 2009-2013: a systematic review

BAGCIVAN¹

2015

TJ Oncol

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RESULTSIn 66% of studies were descriptive. In 38% of the studies, all cancer types were included in the sample. Sample of 94% the of studies were adults, and 31% of the studies were related to "Symptom and Symptom Management" and 65% of this studies were conducted by academician nurses. CONCLUSIONIt was seen that there were a large number of researches conducted in the field of oncology. However it was seen that the majority of these researches have low evidence level, performed by academic nurses, and its samples consisted of adults.

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“…Eight point two million deaths caused by the cancer were kept. (Pinar et al, 2015) Sixty-five percent occurred in less developed areas (Chan & Ismail, 2014). Gynecologic cancer is observed on the top among women that has resulted in death Pinar et al, 2015).…”

Section: Significance Of the Studymentioning

confidence: 99%

Occupational Stress, Job Satisfaction and Cervical Screening Intention of Maternity Oncology Nurses

Hassan¹,

Atwa²

2017

MSHP

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Side Effects of Chemotherapy among Cancer Patients in a Malaysian General Hospital: Experiences, Perceptions and Informational Needs from Clinical Pharmacists

Cited by 130 publications

References 30 publications

Assessment of Adverse Effects of Most Commonly Prescribed Anticancer Drugs in a Tertiary Care Teaching Hospital

Assessment of Adverse Effects of Most Commonly Prescribed Anticancer Drugs in a Tertiary Care Teaching Hospital

Review of oncology nursing research that conducted by nurses in Turkey and published between 2009-2013: a systematic review

Occupational Stress, Job Satisfaction and Cervical Screening Intention of Maternity Oncology Nurses

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