2021
DOI: 10.1002/prp2.745
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Side‐effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta‐analysis of randomized controlled trials

Abstract: Postpartum hemorrhage (PPH) increases the risk of maternal death worldwide. Heat‐stable carbetocin, a long‐acting oxytocin analog, is a newer uterotonic agent. Clinicians do not fully understand its side‐effects, particularly the unanticipated side‐effects. The aim of this study is to investigate the side‐effects of carbetocin to PPH. The Cochrane Library, Web of Science, PubMed, Elsevier ScienceDirect, Embase, and ClinicalTrials.gov were searched from the inception to September 2020. Randomized controlled tri… Show more

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Cited by 10 publications
(11 citation statements)
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“…Importantly, OT‐R are required for CTA development as the OT‐R blockade reduces acquisition of taste aversion and blunts responsiveness of amygdala neurons to an aversive stimulus in mice 29 . The current data are also in line with the clinical reports indicating nausea and emesis after OT infusions in women 25,59‐67 . For women receiving iv injections of oxytocin, pitocin, or carbetocin during labour, nausea and vomiting are common side effects, as noted by many studies 59‐67 …”
Section: Discussionsupporting
confidence: 83%
“…Importantly, OT‐R are required for CTA development as the OT‐R blockade reduces acquisition of taste aversion and blunts responsiveness of amygdala neurons to an aversive stimulus in mice 29 . The current data are also in line with the clinical reports indicating nausea and emesis after OT infusions in women 25,59‐67 . For women receiving iv injections of oxytocin, pitocin, or carbetocin during labour, nausea and vomiting are common side effects, as noted by many studies 59‐67 …”
Section: Discussionsupporting
confidence: 83%
“…But in their study Ai et al, suggested that Carbetocin might be considered an appropriate choice for pregnant women with vomiting intolerance for the prevention of PPH, because on their study demonstrated that the administration of Carbetocin in delivery is associated with a lower incidence of vomiting. (14) Carbetocin should not be used in patients with a history of hypersensitivity to oxytocin or Carbetocin, patients with vascular disease, and Carbetocin are intended for use in children. (15)…”
Section: Discussionmentioning
confidence: 99%
“…Similar to oxytocin, carbetocin has a prominent vasodilatory effect and, if given too quickly, can cause significant hypotension. A systematic review of adverse effects of carbetocin (17 trials, 32 702 participants) identified 24 adverse effects, of which vomiting, nausea, headache and flushing were the most common 6. Other adverse effects that were less commonly reported included shivering, heart disorders, dizziness, dyspnoea and pruritis.…”
Section: About Carbetocinmentioning
confidence: 99%