2023
DOI: 10.1111/dom.14937
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Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects

Abstract: Objectives: Oxytocin (OT) has a well-established role in reproductive behaviours; however, it recently emerged as an important regulator of energy homeostasis. In addition to central nervous system (CNS), OT is found in the plasma and OT receptors (OT-R) are found in peripheral tissues relevant to energy balance regulation.Here, we aim to determine whether peripheral OT-R activation is sufficient to alter energy intake and expenditure. Methods and Results:We first show that systemic OT potently reduced food in… Show more

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Cited by 7 publications
(4 citation statements)
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References 96 publications
(268 reference statements)
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“…There is also evidence that oxytocin can suppress food intake by its peripheral actions. 31,39 The functional organisation of central projections of magnocellular oxytocin neurones, and the relative contribution of axons and dendrites to central oxytocin release, have yet to be fully defined, despite its potential importance for understanding central oxytocin signalling.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is also evidence that oxytocin can suppress food intake by its peripheral actions. 31,39 The functional organisation of central projections of magnocellular oxytocin neurones, and the relative contribution of axons and dendrites to central oxytocin release, have yet to be fully defined, despite its potential importance for understanding central oxytocin signalling.…”
Section: Discussionmentioning
confidence: 99%
“…The central release of oxytocin appears to modulate the motivation to eat by its actions not only in the hypothalamus, but also in the amygdala 33 and at forebrain sites such as the nucleus accumbens 2,34–36 and the ventral tegmental area, 37,38 where it may be involved in food reward. There is also evidence that oxytocin can suppress food intake by its peripheral actions 31,39 …”
Section: Discussionmentioning
confidence: 99%
“…Finally, we confirmed functionality post Cbi oxidation by screening one of the peptides, OT, both free and after conjugation to B 12 at the oxytocin receptor with equipotent agonism recorded (K D = 4.39 and 4.63 nM, respectively). 43 In conclusion, Cbi is a powerful catalyst for the oxidation of cysteine residues in peptides synthesized via SPPS. Cbi can be synthesized from vitamin B 12 or purchased commercially.…”
mentioning
confidence: 96%
“…Finally, we confirmed functionality post Cbi oxidation by screening one of the peptides, OT , both free and after conjugation to B 12 at the oxytocin receptor with equipotent agonism recorded ( K D = 4.39 and 4.63 nM, respectively). 43…”
mentioning
confidence: 99%