Side effects of botulinum toxin injection for benign anal disorders

Madalinski, Mariusz; Sławek, Jarosław; Duzynski, Wojciech; Zbytek, Blazej; Jagiello, K; Adrich, Z; Kryszewski, A

doi:10.1097/00042737-200208000-00007

Cited by 43 publications

(38 citation statements)

References 13 publications

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“…It was consistent with our previous observation [10] and later with Brisinda et al's report that "higher doses can lead to higher success rate" [11]. Furthermore, it is common knowledge that side effects are unlikely even following higher doses of BT-A for the treatment of anal fissure [3,11].…”

Section: Discussionsupporting

confidence: 92%

“…Incontinence problems after pharmacological sphincteroto-M.H. Madaliński: Botulinum toxin for secondary anal fissure my are rare and usually mild [1][2][3]. Furthermore, it was difficult to offer a surgical procedure when three of the patients were dissatisfied with their previous surgical therapy for hemorrhoids and three others agreed to undergo hemorrhoid ligation because they were afraid of postoperative pain and complications.…”

Section: Discussionmentioning

confidence: 99%

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Botulinum toxin for the treatment of secondary chronic anal fissure

Madalinski¹

2003

Techniques in Coloproctology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Botulinum toxin for the treatment of secondary chronic anal fissure

Madalinski¹

2003

Techniques in Coloproctology

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“…Studies by Giral et al [32] and Lysy et al [33] attempted injection on both sides of the fissure with success. Injections into external anal sphincters have also produced favourable results [13,34]. Rapid onset of action makes the patient pain-free within hours of treatment [24].…”

Section: Site Dose and Proceduresmentioning

confidence: 99%

“…A number of isolated studies have been done with different doses ranging from 2.5 to 25 units of Botox ® on each side [13,29,31,[35][36][37][38][39][40][41]. Optimum total dose seems to be 20 to 50 units of Botox ® or 0.3 units / kg [42].…”

Section: Site Dose and Proceduresmentioning

confidence: 99%

“…BT-A is an endopolypeptidase [13] and is the most potent [14] biological neurotoxin being used in modern medicine. It is produced by the anaerobic bacterium Clostridium botulinum and acts by preventing acetyle choline release at the neuromuscular junction [15 16], thereby reducing the myogenic tone and the contractile response of the muscle.…”

Section: Introductionmentioning

confidence: 99%

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Botulinum toxin A and chronic anal fissures – a literature review

et al. 2006

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Zusammenfassung. Grundlagen: Botulinumtoxin A (BT-A) wird zur Therapie der chronischen Analfissur verwendet. In diesem Review wird versucht, die derzeitigen Ergebnisse in der Therapie der chronischen Analfissur mit BT-A zu beleuchten.Methodik: Studien zum Thema BT-A in der Behandlung der chronischen Analfissur wurden durch eine Medline-Suche identifiziert. Alle relevanten Studien wurden inkludiert. Relevante zitierte Referenzen (cross references) wurden ebenfalls berücksichtigt.Ergebnisse: BT-A hat einen vorübergehenden paralytischen Effekt auf den Schließmuskel. Die Erfolgsraten in der Behandlung der chronischen Analfissur sind unterschiedlich. Langzeitergebnisse mit der Behandlung mit BT-A sind besser als bei Verwendung topischer nitrathäl-tiger Medikamente, allerdings schlechter als nach lateraler Sphinkterotomie. Mehrmalige BT-A-Injektionen sind in vielen Fällen notwendig. Vorteil der Verwendung von BT-A sind die Einfachheit der Applikation und das Fehlen von bleibenden Nebenwirkungen.Schlussfolgerungen: BT-A sollte bei Therapieversagen nach topischen Nitraten und bei hohem Narkoserisiko zur Therapie der chronischen Analfissur bedacht werden. Aufgrund der geringen Komplikationsrate und der vorü-bergehenden Wirkung sollte die Injektion von BT-A vor einer chirurgischen Therapie angeboten werden.All relevant trials, studies, experiences and cross references were included.Results: Botulinum toxin A has a demonstrable temporary paralytic effect on the anal sphincters. A varied rate of success has been observed with its use in management of anal fissures. The long term results are superior to those of exogenous nitric oxide donors and inferior to Lateral internal sphincterotomy. The need for re-injection and high recurrence rate makes it less effective than surgical options but its simplicity and lack of permanent complications make it a desirable option.Conclusions: Botulinum toxin should be considered in uncomplicated idiopathic chronic anal fissures refractory to topical nitric oxide donors and in patients unfit for anaesthesia. In view of its low complication rates and temporary effect on sphincters, it should be offered as an option prior to considering surgical intervention on the anal sphincters.

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Gastrointestinal and Swallowing Disturbances in Parkinson's Disease

Pfeiffer

2011

Parkinson's Disease

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Side effects of botulinum toxin injection for benign anal disorders

Abstract: Treatment with BT-A is safe. Despite the application of higher doses of BT-A in the treatment of benign anal disorders so far, no severe side effects were observed.

Cited by 43 publications

References 13 publications

Botulinum toxin for the treatment of secondary chronic anal fissure

Botulinum toxin for the treatment of secondary chronic anal fissure

Botulinum toxin A and chronic anal fissures – a literature review

Gastrointestinal and Swallowing Disturbances in Parkinson's Disease

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