Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell

Singh, Rochika; Sripada, Lakshmi; Singh, Rajesh

doi:10.1016/j.mito.2013.10.005

Cited by 103 publications

(71 citation statements)

References 45 publications

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“…The constant exposure of mitochondrial DNA to the oxidative environment in the cells has made it more prone to mutations. These mitochondrial mutations and genetic variability may have implications in influencing antibiotic selectivity and sensitivity to the host cell [86].…”

Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

“…Accumulating evidence has highlighted that the use of aminoglycosides such as streptomycin, gentamycin, neomycin, kanamycin, etc., either in high doses or for extended periods, potentially results in nephrotoxicity, ototoxicity, and hearing loss. The sensitivity of mutations associated with hearing loss and deafness in mitochondria, such as m. 1555A>G [89], m. 1494C>T [90,91], m. 1095T>C [92], m. 827A>G [93], m. 1645C>G, m. 3243A>G, and m. 961A>G, to aminoglycosides, indicates their role in inducing the phenotype in Chinese and Spanish populations [86,94].…”

Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

“…Chloramphenicol is also associated with the C2939A, T2991C mutations and side effects including myelosuppression, lactic acidosis, peripheral neuropathies, etc. It has been reported that the use of linezolid resulted in low levels of mitochondrial translational products and lactic acidosis associated with A2706G as well as G3010A mutations, in addition to other side effects [86]. Streptomycin administration linked with G1555A mutation results in ototoxicity and deafness [89].…”

Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

See 2 more Smart Citations

Antibiotics-Induced Obesity: A Mitochondrial Perspective

Andrade

Jayaprakash

Bhat

et al. 2017

Public Health Genomics

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Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity. Apart from the involvement of biosocial causes influencing diet, physical activity, and antibiotic use, pathogenesis of obesity is linked to interconnected functional alterations in cells, tissues and organs due to biochemical, epigenetic and genetic factors. Mitochondrial dysfunction is one such factor, which is becoming the primary focus of various aspects of research on multifactorial complex diseases and is providing new perspectives on etiology, biomarker-based diagnosis, and drug sensitivity. Through this review, we have made an attempt to present the interplay between use of antibiotics, obesity, and associated mitochondrial dysfunction. This may provide insights into the molecular basis, genetic predisposition and environmental triggers, which in turn may have potential clinical applications in the management of antibiotic use.

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Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

Section: Mitochondrial Dna Mutations Associated With Antibioticsmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotics-Induced Obesity: A Mitochondrial Perspective

Andrade

Jayaprakash

Bhat

et al. 2017

Public Health Genomics

View full text Add to dashboard Cite

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“…In the clinic, administration of rifaximin could decrease the circulating endotoxin and ALT levels in patients with NAFLD [150]. Although the improvement in NAFLD, especially in NASH by short-term administration of antibiotic is observed (i. g rifaximin), the long-term application of antibiotics is not encouraged because of probable side effects [151].…”

Section: Gut Microbiota-targeted Therapies With Other Approachesmentioning

confidence: 99%

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Ma¹,

Zhou²,

Li³

2017

Preprint

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Gut microbiota play critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance, which highlighted the potential of gut microbiota-targeted therapies on these diseases. There are various ways that can manipulate gut microbiota including probiotics, prebiotics, synbiotics, antibiotics and some active components from herbal medicines. In this review, we first described the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies in NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiotatargeted therapies in the future.

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“…Inorganic nanoparticles (NPs) are claimed to be more biocidal than many conventional antibiotics, which utilization at high concentrations can induce adverse effects and toxicity to human cells [9,10]. The use of antibacterial NPs is also among the most promising strategies to overcome the microbial drug resistance [11].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous sonochemical-enzymatic coating of medical textiles with antibacterial ZnO nanoparticles

Petkova

Francesko

Perelshtein

et al. 2016

Ultrasonics Sonochemistry

118

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The antimicrobial finishing is a must for production of medical textiles, aiming at reducing the bioburden in clinical wards and consequently decreasing the risk of hospital-acquired infections.This work reports for the first time on a simultaneous sonochemical/enzymatic process for durable antibacterial coating of cotton with zinc oxide nanoparticles (ZnO NPs). The novel technology goes beyond the "stepwise" concept we proposed recently for enzymatic preactivation of the fabrics and subsequent sonochemical nano-coating, and is designed to produce "ready-to-use" antibacterial medical textiles in a single step. A multilayer coating of uniformly dispersed NPs was obtained in the process. The enzymatic treatment provides better adhesion of the ZnO NPs and, as a consequence, enhanced coating stability during exploitation. The NPscoated cotton fabrics inhibited the growth of the medically relevant Staphylococcus aureus and Escherichia coli respectively by 67 % and 100 %. The antibacterial efficiency of these textile materials resisted the intensive laundry regimes used in hospitals, though only 33 % of the initially deposited NPs remained firmly fixed onto the fabrics after multiple washings.

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Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell

Cited by 103 publications

References 45 publications

Antibiotics-Induced Obesity: A Mitochondrial Perspective

Antibiotics-Induced Obesity: A Mitochondrial Perspective

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Simultaneous sonochemical-enzymatic coating of medical textiles with antibacterial ZnO nanoparticles

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