Antibiotics-Induced Obesity: A Mitochondrial Perspective

Andrade, Melisa J.; Jayaprakash, Chinchu; Bhat, Smitha; Evangelatos, Nikolaos; Brand, Angela; Satyamoorthy, Kapaettu

doi:10.1159/000485095

Cited by 18 publications

(8 citation statements)

References 181 publications

(179 reference statements)

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“…LPS itself can augment the food absorption in experimental animals also. Similar pathomechanism was observed in the cases of antibiotic induced obesity in humans, particularly in children, as well [4,5,6,7,8].…”

Section: Trends In Antibiotic Consumption (Human Non-human)supporting

confidence: 69%

Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Ternák¹

2019

BIO

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The rapid, pandemic-like, spread of certain noncontagious diseases (NCDs), like (childhood) obesity, type2 diabetes mellitus, particularly in children, autism, Alzheimer diseases, etc. prompted the researches to try to find appropriate explanation for this phenomenon. The well-known association between antibiotic enriched fodder and the weight gain of food animals, through the modification of the gut flora, clearly raises the possibility of similar relationship in human beings as well, which was described in several publications. The role of obesity in the development of diabetes is a well-known also. The antibiotic consumption pattern in the World clearly demonstrated the extensive utilization of the broad spectrum antibiotics, starting about three decades ago, and the appearance of still active degradation products in the environment, which might reenter into humans and animals again, and as the result of the alteration of human microbiome, could induce the pandemiclike NCDs. The yet to be explained rapid increase of prevalence of autism and Alzheimer diseases observed in the past three decades is alarming. According to a CDC survey, the prevalence of autism in the surveyed population was estimated as 16.8 per 1,000 (one in 59) children aged 8 years, which is considered as a 150% increase from the year 2000. The prevalence of Alzheimer's disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). Microbiome alterations were observed in both cases and obesity is present in the 30% of autism as well. Putting together the mosaics from relevant publications, it might be concluded that we face the long term side effects of antibiotic consumption/pollution manifesting, through the alteration of microbioms as the pandemic appearance of certain NCDs. The restoration of the "normal" gut flora by fecal microbiota transfer (FMT) might be an option to influence those conditions.

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Section: Trends In Antibiotic Consumption (Human Non-human)supporting

confidence: 69%

Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Ternák¹

2019

BIO

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“…Thus, almost all of the nonantibiotics mentioned above affect mitochondrial functions being either part of their modes of action or potential toxicities. Many antibiotics cause mitochondrial dysfunction, too, thus explaining their anti-neoplastic activities [30], or possibly promoting tumorigenesis [265][266][267][268], obesity [269], and psychiatric disorders [270,271]. Thus, antibiotics as well as non-antibiotics exert beneficial or detrimental antimitochondrial activities.…”

Section: Conclusion and Open Questionsmentioning

confidence: 99%

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Dalhoff

2020

Infection

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Purpose Advances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the analysis of the ancestry of pro- and eukaryotic genes and proteins. Methods This review summarizes findings of structural and/or functional homologies of pro- and eukaryotic enzymes catalysing analogous biological reactions because of their highly conserved active centres so that non-antibiotics interacted with bacterial targets. Results Protease inhibitors such as staurosporine or camostat inhibited bacterial serine/threonine or serine/tyrosine protein kinases, serine/threonine phosphatases, and serine/threonine kinases, to which penicillin-binding-proteins are linked, so that these drugs synergized with β-lactams, reverted aminoglycoside-resistance and attenuated bacterial virulence. Calcium antagonists such as nitrendipine or verapamil blocked not only prokaryotic ion channels but interacted with negatively charged bacterial cell membranes thus disrupting membrane energetics and inducing membrane stress response resulting in inhibition of P-glycoprotein such as bacterial pumps thus improving anti-mycobacterial activities of rifampicin, tetracycline, fluoroquinolones, bedaquilin and imipenem-activity against Acinetobacter spp. Ciclosporine and tacrolimus attenuated bacterial virulence. ACE-inhibitors like captopril interacted with metallo-β-lactamases thus reverting carbapenem-resistance; prokaryotic carbonic anhydrases were inhibited as well resulting in growth impairment. In general, non-antibiotics exerted weak antibacterial activities on their own but synergized with antibiotics, and/or reverted resistance and/or attenuated virulence. Conclusions Data summarized in this review support the theory that prokaryotic proteins represent targets for non-antibiotics because of a common evolutionary origin of bacterial- and mammalian targets resulting in highly conserved active centres of both, pro- and eukaryotic proteins with which the non-antibiotics interact and exert antibacterial actions.

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“…La disbiosis afecta la adiposidad del huésped a través de una vía de señalización integral (Cinpeanu, Rus & Tarcea, 2019;Bashiardes, et al, 2018). La dieta, la actividad física, el estrés metabólico, los xenobióticos, la microbiota, el sexo y la edad; modulan la metilación de ADN en sangre y tejidos que están asociados con fenotipos de obesidad, siendo este mecanismo epigenético el más estudiado en la etiología de la obesidad (Flandroy, et al, 2019;de Toro, et al, 2019;Andrade, et al, 2017).…”

Section: Conceptualización Actual De La Obesidadunclassified

Revisión de la obesidad como concepto científico (Obesity review as a scientific concept)

Lobato

Rovira

Tovilla

et al. 2021

Retos

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El lenguaje según Noam Chomsky, es una capacidad innata que puede emplearse para comunicar la ciencia. Analizar el término obesidad como concepto científico, permitirá su correcto abordaje epistemológico para contribuir con la investigación científica multidisciplinaria que busca reducir esta pandemia. La obesidad es una acumulación excesiva de grasa corporal, por encima de las necesidades fisiológicas y capacidad de adaptación, que puede conducir a efectos adversos para la salud, como una discapacidad. Se considera un estado en el que el tejido adiposo representa más del 20% del peso corporal total en hombres y el 25% en mujeres. Un IMC de 30 kg/m2 o más se cataloga como obesidad. Desde una perspectiva genética, la obesidad es clasificada en tres subdivisiones de acuerdo con el trastorno y número de genes involucrados: monogénica, sindrómica y poligénica. Para las ciencias sociales, involucra un problema sociocultural injertado en una predisposición a nivel individual. Desde la perspectiva evolutiva, el cuerpo humano no está desarrollado para la exposición constante a un ambiente rico en calorías y sedentario. Comprender las perspectivas teóricas actuales que conceptualizan a la obesidad, estipulada como patología en sí misma, como factor de riesgo para las demás enfermedades no transmisibles y como etiología indirecta de discapacidad, permitirá que la investigación científica pueda desarrollarse con panoramas más amplios, a través de su diseño con variables, categorías y teorías mixtas, que permitan formular hipótesis y explicaciones con un enfoque multidisciplinario, en concordancia con la etiología multifactorial de la obesidad. Abstract. Language according to Noam Chomsky, is an innate ability that can be used to communicate science. Analyzing the term obesity as a scientific concept will allow its correct epistemological approach to contribute to multidisciplinary scientific research that seeks to reduce this pandemic. Obesity is an excessive accumulation of body fat, in excess of physiological needs and adaptability, which can lead to adverse health effects, such as disability. It is considered a state in which adipose tissue represents more than 20% of total body weight in men and 25% in women. A BMI of 30 kg / m2 or more is classified as obesity. From a genetic perspective, obesity is classified into three subdivisions according to the disorder and number of genes involved: monogenic, syndromic and polygenic. For the social sciences, it involves a sociocultural problem grafted onto a predisposition at the individual level. From an evolutionary perspective, the human body is not developed for constant exposure to a calorie-rich and sedentary environment. Understanding the current theoretical perspectives that conceptualize obesity, stipulated as a pathology in itself, as a risk factor for other non-communicable diseases and as an indirect etiology of disability, will allow scientific research to be developed with broader perspectives, through its design with mixed variables, categories and theories, which allow the formulation of hypotheses and explanations with a multidisciplinary approach, in accordance with the multifactorial etiology of obesity.

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Antibiotics-Induced Obesity: A Mitochondrial Perspective

Cited by 18 publications

References 181 publications

Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Antibiotic-modified Microbiome Might Be Responsible for Non-contagious World-wide Epidemics

Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Revisión de la obesidad como concepto científico (Obesity review as a scientific concept)

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