Sickness behavior of rats with abdominal sepsis can be improved by antibiotic and G-CSF prophylaxis in clinic modeling randomized trials

Bauhofer, A.; Schwarting, Rainer K.W.; Köster, Michael; Schmitt, Arbogast; Lorenz, W.; Pawlak, Cornelius R.

doi:10.1007/s00011-004-1314-9

Cited by 10 publications

(3 citation statements)

References 54 publications

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“…But interestingly, there have been reports from the present laboratory showing no substantial differences in total open arm times and other behaviors for rats tested in the elevated plus-maze (and open field) comparing daytime (e.g., Pawlak & Schwarting, 2002) with night time (Bauhofer et al, 2004), or after transient isolated housing beginning immediately after weaning (Schwarting & Pawlak, 2004). Finally, combined handling (i.e., picking up the animal) and gentling (i.e., gentle stroking to familiarize the animal with the experimenter more thoroughly than purpose-defined handling) did not affect open arm time or entries, but risk assessment (see following lines), in the elevated plus-maze (Borta, Wöhr, & Schwarting, 2006).…”

Section: Rationale Set-up Proceduresmentioning

confidence: 57%

The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior

et al. 2012

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The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and introduction about the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here.

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Section: Rationale Set-up Proceduresmentioning

confidence: 57%

The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior

et al. 2012

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“…They also spent significantly more time grooming. These findings, demonstrating less activity in the open field in nLPS female rats, are suggestive of more sickness behaviour in these animals (30–33). We have previously seen that nLPS alters some basal indices of anxiety (21) and at least one other group has found increased anxiety after adult psychological stress in adult rats treated neonatally with LPS (34).…”

Section: Discussionmentioning

confidence: 78%

Neonatal Programming by Neuroimmune Challenge: Effects on Responses and Tolerance to Septic Doses of Lipopolysaccharide in Adult Male and Female Rats

Spencer

Pittman

2010

J Neuroendocrinology

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A mild immune challenge experienced during the neonatal period leads to attenuated febrile responses to a similar challenge experienced later in life. However, the immune response to an endotoxin differs depending upon the severity of the challenge and it is not clear whether a neonatal immune challenge will also affect responses to a severe, potentially life-threatening stimulus, such as sepsis. In the present study, we examined the effects of a neonatal immune challenge with lipopolysaccharide (LPS) on adult sickness responses, as well as the development of endotoxin tolerance, to a septic dose (1 or 3 mg/kg) of the same LPS in male and female rats. We demonstrate significant differences, particularly in males, in the fever profiles of neonatally LPS-treated rats compared to neonatally saline-treated controls. Specifically, male rats treated neonatally with LPS have reduced hypothermic and enhanced hyperthermic responses to both septic doses of LPS in adulthood. A somewhat different profile is seen in females, with neonatally LPS-treated females having reduced hypothermia and enhanced hyperthermia compared to controls with 1 mg/kg but no differences with 3 mg/kg LPS. The results obtained demonstrate that alterations in innate immune responses previously reported for low doses of LPS can, for the most part, also be observed after severe immune challenge in later life.

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“…Recently, we showed in clinic modeling randomized trials (CMRTs) in rats that sepsis leads to reduced behavioral activity which can be monitored continuously in the home cage by radio-telemetry [9,10] or in well-established behavioral tests like the open field, elevated plus-maze, and social interaction test [11]. Out of these, the open field test is widely used as a standard screening procedure to measure psychomotor activity and exploration [12,13].…”

Section: Introductionmentioning

confidence: 99%

Individual behavioral differences in recovery from abdominal sepsis in rats

Bauhofer

Schmitt

et al. 2009

Inflamm. Res.

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Sickness behavior of rats with abdominal sepsis can be improved by antibiotic and G-CSF prophylaxis in clinic modeling randomized trials

Abstract: The results show that improving sickness behavior in septic rats with G-CSF plus antibiotics may be a promising approach.

Cited by 10 publications

References 54 publications

The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior

The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior

Neonatal Programming by Neuroimmune Challenge: Effects on Responses and Tolerance to Septic Doses of Lipopolysaccharide in Adult Male and Female Rats

Individual behavioral differences in recovery from abdominal sepsis in rats

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