Sickness behavior is accentuated in rats with metabolic disorders induced by a fructose diet

Orlandi, Lidiane; Fonseca, Wesley F.; Enes-Marques, Silvia; Paffaro, Valdemar A.; Vilela, Fabiana C.; Giusti‐Paiva, Alexandre

doi:10.1016/j.jneuroim.2015.10.014

Cited by 19 publications

(12 citation statements)

References 60 publications

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“…LPS, a biologically active component of the outer membrane of gram negative bacteria, is widely used in experimental animal model in order to induce systemic inflammation [ 27 ], stimulate the release of pro-inflammatory cytokines in the brain areas [ 28 ] and produce sickness behaviors [ 29 ]. Peripheral LPS administration produces anxiety-like behaviors in EPM and OFT [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Yang

Jang

Ryu

et al. 2017

BMC Complement Altern Med

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BackgroundAcupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disorders. The aim of this study was to evaluate the effects of acupuncture on lipopolysaccharide (LPS)-induced anxiety-like behaviors and SERT in the dorsal raphe nuclei (DRN).MethodsRats were given acupuncture at ST41 (Jiexi), LI11 (Quchi) or SI3 (Houxi) acupoint in LPS-treated rats. Anxiety-like behaviors of elevated plus maze (EPM) and open field test (OFT) were measured and expressions of SERT and/or c-Fos were also examined in the DRN using immunohistochemistry.ResultsThe results showed that 1) acupuncture at ST41 acupoint, but neither LI11 nor SI3, significantly attenuated LPS-induced anxiety-like behaviors in EPM and OFT, 2) acupuncture at ST41 decreased SERT expression increased by LPS in the DRN.ConclusionsOur results suggest that acupuncture can ameliorate anxiety-like behaviors, possibly through regulation of SERT in the DRN.

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Section: Discussionmentioning

confidence: 99%

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Yang

Jang

Ryu

et al. 2017

BMC Complement Altern Med

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“…The tissue collection and biochemical analysis for the offspring (n = 8 per group) was performed as previously described, for the dams (Orlandi et al, 2015). In addition, at PND 30‐32, before the animals were decapitated, they were individually weighed.…”

Section: Methodsmentioning

confidence: 99%

“…After the mice were sacrificed, perigonadal and retroperitoneal adipose tissue samples were harvested and weighed. Commercial kits from in vitro Diagnostica Ltd. (Itabira-MG, Brazil) were used to measure plasma total cholesterol, triglycerides, and glucose by the absorbance method (Orlandi et al, 2015).…”

Section: Tissue Collection and Biochemical Analysismentioning

confidence: 99%

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

Ribeiro

Batista

Veronesi

et al. 2018

Intl J of Devlp Neuroscience

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The objective of this study was to investigate the effect of exposure to maternal consumption of a hyperenergetic, highly palatable diet, known as the cafeteria diet, during the gestation period on the development and behavior of offspring. For this, we used pregnant female mice that were fed a normal or a cafeteria diet during the gestation period. The evaluation of maternal behavior in lactating dams was performed from the second to the eighth day postpartum (PND 2-8). Weight gain, feed intake, and energy intake were recorded during the gestation period. In the offspring, reflex parameters and physical development were evaluated during the lactation period and when they reached adolescence. Behavioral performance was evaluated in light-dark, open-field, and play behavior tests. In addition, biochemical parameters of the dams and the adolescent offspring were evaluated. The cafeteria diet during gestation altered maternal behavior and the onset of physical and neurodevelopmental landmarks and had an impact on emotional and play behavior in adolescent offspring. In conclusion, our results demonstrate that exposure to maternal consumption of a cafeteria diet during the gestation period can program developmental and behavioral courses in the offspring.

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“…Obesity is shown to be associated with increased susceptibility to post-operative infections in humans ( 1 – 4 ) and experimental induced infection in rodents ( 5 – 7 ). Lipopolysaccharide (LPS) is a bacterial endotoxin and widely used to investigate the acute phase response upon infection in rodents ( 6 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…Both these effects could be involved in the exacerbated immune response during obesity upon infection. It is, however, difficult to distinguish between metabolic changes due to obesity or direct effects of fat and sugar from the diet in studies in obese rats ( 6 , 7 ), as the animals are exposed to a high-palatable diet for a prolonged period resulting in 15% difference in body weight gain and excessive fat accumulation ( 6 ). Interestingly, a recent study showed a hypothalamic inflammatory response already after 3 days of high-fat diet feeding ( 19 ) before animals became obese.…”

Section: Introductionmentioning

confidence: 99%

One-Week Exposure to a Free-Choice High-Fat High-Sugar Diet Does Not Interfere With the Lipopolysaccharide-Induced Acute Phase Response in the Hypothalamus of Male Rats

et al. 2018

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Obesity has been associated with increased susceptibility to infection in humans and rodents. Obesity is also associated with low-grade hypothalamic inflammation that depends not only on body weight but also on diet. In the present study, we investigated if the bacterial endotoxin [lipopolysaccharide (LPS)]-induced acute phase response is aggravated in rats on a 1-week free-choice high-fat high-sugar (fcHFHS) diet and explained by diet-induced hypothalamic inflammation. Male Wistar rats were on an fcHFHS diet or chow for 1 week and afterwards intraperitoneally injected with LPS or saline. Hypothalamic inflammatory intermediates and plasma cytokines were measured after LPS. Both LPS and the fcHFHS diet altered hypothalamic Nfkbia mRNA and nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha (NFKBIA) protein levels, whereas Il1β, Il6, and Tnfα mRNA expression was solely induced upon LPS. We observed an interaction in hypothalamic Nfkbia and suppressor of cytokine signaling (SOCS) 3 mRNA upon LPS; both were higher in rats on a fcHFHS diet compared with chow animals. Despite this, plasma cytokine levels between fcHFHS diet-fed and chow-fed rats were similar after LPS administration. Consuming a fcHFHS diet but not LPS injections increased hypothalamic Atf4 (a cellular stress marker) mRNA expression, whereas Tlr4 mRNA was decreased only upon LPS. Our study does not support a role for diet-induced mild hypothalamic inflammation in the increased susceptibility to infection despite altered Nfkbia and Socs3 mRNA expression after the diet. Additional factors, related to increased fat mass, might be involved.

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Sickness behavior is accentuated in rats with metabolic disorders induced by a fructose diet

Cited by 19 publications

References 60 publications

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring

One-Week Exposure to a Free-Choice High-Fat High-Sugar Diet Does Not Interfere With the Lipopolysaccharide-Induced Acute Phase Response in the Hypothalamus of Male Rats

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