Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Yang, Tae Young; Jang, Eun Young; Ryu, Yeonhee; Lee, GyuWon; Lee, Eun Byeol; Chang, Suchan; Lee, Jong Han; Koo, Jin Suk; Yang, Chae Ha; Kim, Hee Young

doi:10.1186/s12906-017-2039-y

Cited by 19 publications

(24 citation statements)

References 44 publications

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“…Acupuncture is widely used to treat psychological problems such as anxiety and depression, and in many tests shows that acupuncture rarely gives serious side effects [20]. Acupuncture can work by regulating the level of inflammatory cytokines produced by lipopolysaccharide (LPS) by inducing inflammatory cytokines (tumor necrosis factor (TNF) α, interleukin (IL) -1β, IL-6) which can trigger depression or anxiety behavior [21]. Research conducted by Yue, et al showed that Electroacupuncture (EA) significantly reversed the increase induced Chronic Unpredictable Stress (CUS) on P2X7, Iba-1, IL-18 receptors, TNFα, and IL-6 expression and concluded that EA show antidepressant effects and reduce inflammation of the hippocampal nerve [22].…”

Section: Resultsmentioning

confidence: 99%

Acupoint Manipulation in Elderly with Comorbid Disorders

Sudjiwanati¹,

Suparno²

2019

Proceedings of the 6th International Conference on Community Development (ICCD 2019)

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Health problems in the elderly are a natural thing to experience because there is a decline in the function of the organs of the body. Health problems in the elderly can be a serious problem because there are disorders of several diseases that occur simultaneously or known as comorbidity, not only physical disorders but also mental disorders. Therapy given at certain acupoints points is expected to help the elderly in reducing the disorder suffered. The research aimed to determine the effect of acupoint manipulation therapy on the health of elderly with comorbid disorders. The research method used was an experiment with pre and post-test. The number of samples used was 20 elderly with mental-physical comorbid disorders and divided into control groups and treatment groups. The treatment group will be given acupoint manipulation therapy and art therapy. Blood samples will be analyzed in a laboratory to determine the levels of TNF-α in the blood, and mental health conditions obtained from the results of graphical tests. The results showed that the levels of TNF-α and the results of the treatment group psychological test showed no significant results on the control group, but the level of anxiety and TNF-α values in the treatment group was better than the control group. Based on the results of the study it can be concluded that acupoint manipulation therapy has not been able to provide good results, but there is hope that acupoint manipulation therapy can be developed as a complementary treatment method.

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Section: Resultsmentioning

confidence: 99%

Acupoint Manipulation in Elderly with Comorbid Disorders

Sudjiwanati¹,

Suparno²

2019

Proceedings of the 6th International Conference on Community Development (ICCD 2019)

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“…The results of our behavioral investigations indicated anxiolytic-like effects of GPS in an animal model of anxiety. Administration of GPS after LPS injection significantly reduced anxiety-like behaviors in the EPM test, as indicated by increased exploratory behaviors, and more entries into the open arms (Yang et al 2017 ). Administration of GPS after LPS injection also significantly increased the number of central zone crossings in the OFT (Yang et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Administration of GPS after LPS injection significantly reduced anxiety-like behaviors in the EPM test, as indicated by increased exploratory behaviors, and more entries into the open arms (Yang et al 2017 ). Administration of GPS after LPS injection also significantly increased the number of central zone crossings in the OFT (Yang et al 2017 ). Therefore, because behaviors in the EPM test and OFT are related to LPS-related psychological symptoms, our results suggest that GPS may inhibit neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Anxiety disorders, also referred to as generalized social anxiety and panic disorders, are the most common mental health disorders, and are characterized by irritability, fatigue, restlessness, muscle tension, sleep problems, intense and persistent fear of social situations, and recurrent and unexpected panic attacks (Yang et al 2017 ). Many recent studies have demonstrated that neuroinflammatory and sustained increases in various proinflammatory mediators, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in the central nervous system are closely related to neuropsychiatric disorders, such as anxiety (Dantzer et al 2008 ; Vogelzangs et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

“…Many recent studies have demonstrated that neuroinflammatory and sustained increases in various proinflammatory mediators, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in the central nervous system are closely related to neuropsychiatric disorders, such as anxiety (Dantzer et al 2008 ; Vogelzangs et al 2013 ). Lipopolysaccharide (LPS) is a non-infectious element of the external membranes of gram-negative bacteria that regulates proinflammatory cytokines (Yang et al 2017 ). Systemic injection of LPS causes physiological or psychiatric changes such as anhedonia, anorexia, depressed mood, apathy and anxiety (Dantzer et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%

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Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats

Lee

Shim

Lee

et al. 2018

Animal Cells and Systems

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Neuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including antiinflammatory, antioxidative, and protective properties. The present study was performed to examine whether GPS shows anxiolytic-like effects in a model of chronic inflammation induced by injection of lipopolysaccharide (LPS) into the rat hippocampus. The effects of GPS on inflammatory factors in the hippocampus and the downstream mechanisms of these effects were also examined. Introduction of LPS into the lateral ventricle caused inflammatory reactions and anxiety-like symptoms in the rats. Daily treatment with GPS (25, 50, and 100 mg/kg) for 21 consecutive days significantly increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. Moreover, GPS administration significantly reduced the freezing response to contextual fear conditioning, and significantly decreased the levels of proinflammatory mediators, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and nuclear factor-kappaB (NF-κB), levels in the brain. Furthermore, GPS reduced LPS-induced elevated levels of Toll-like receptor 4 (TLR4) mRNA and inhibition of brain-derived neurotrophic factor (BDNF) mRNA levels. Taken together, these results suggest that GPS may have anxiolytic-like effects and may have novel therapeutic potential for anxiety-like behaviors caused by neuroinflammation. GPS may be useful for developing an agents for the treatment of neuropsychiatric disorders, such as anxiety, due to its antiinflammatory activities and the modulation of NF-κB/iNOS/TLR4/BDNF.

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Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats

Zhang

Lin

et al. 2018

Acta Pharmaceutica Sinica B

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Dissolving microneedles carried drug molecules can effectively penetrate the stratum corneum of skin to improve the transdermal drug delivery. The traditional Chinese medicine acupuncture is based on the needle stimulation at a specific location (acupoint) to generate and transmit biochemical and physiological signals which alter the pathophysiological state of patients. However, the pain associated with conventional acupuncture needles and the requirement of highly trained professionals limit the development of acupuncture in non-Asian countries. The purpose of this study is to investigate whether the dissolving microneedles can be utilized as a self-administered painless replacement for acupuncture and locally released drug molecules can achieve expected therapeutic outcomes. Immunosuppressive rats were treated with acupuncture at Zusanli (ST36) acupoint using microneedles containing thymopentin. The immune functions and psychological mood of the immunosuppressed animals were examined. The proliferation of splenocytes was examined by CCK-8 assay. CD4 and CD8 expression patterns in spleen cells were detected by flow cytometry. The current study showed that use of either microneedles containing thymopentin or conventional acupuncture both resulted in immune cell proliferation, which was confirmed by flow cytometry. Furthermore, either conventional acupuncture or microneedles were able to effectively mitigate the anxiety caused by immune-suppression when applied on the ST36.

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Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

Cited by 19 publications

References 44 publications

Acupoint Manipulation in Elderly with Comorbid Disorders

Acupoint Manipulation in Elderly with Comorbid Disorders

Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats

Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats

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