Sickle Cell Disease in Children

Characteristics and outcomes of osteomyelitis in children with sickle cell disease: A 10‐year single‐center experience

“…In our cohort, we did not find significant differences in demographics, fever characteristics, sickle cell genotypes, WBC count at presentation, or frequency of positive blood cultures in patients treated for OM compared to those not treated for OM. This is contrary to the study by Berger et al, which showed an increased likelihood of OM with the presence of prolonged fever, bone pain, and swelling and/or leukocytosis 5 …”

“…During this time, 28 children with SCD were treated for OM, while the remaining 31 children with clinical concerns for OM were evaluated with MRI and eventually diagnosed to have SCD‐related VOC/bone infarction and not OM. Similar to previous reports, we found that most patients who were diagnosed with OM were older children with homozygous hemoglobin SS, however one patient in our cohort was an infant, stressing the importance of considering this diagnosis in all age groups 5,9 . Extremity long bones were the most common sites of involvement in our cohort.…”

“…Our study highlights the challenges that clinicians continue to face in diagnosing OM in children with SCD 4,5,9 . In our cohort, we did not find significant differences in demographics, fever characteristics, sickle cell genotypes, WBC count at presentation, or frequency of positive blood cultures in patients treated for OM compared to those not treated for OM.…”

“…Similar to previous reports, we found that most patients who were diagnosed with OM were older children with homozygous hemoglobin SS, however one patient in our cohort was an infant, stressing the importance of considering this diagnosis in all age groups. 5,9 Extremity long bones were the most common sites of involvement in our cohort. While some patients experienced significant morbidity (ie, need for surgical interventions, development of chronic OM), clinical resolution of OM was achieved in all patients.…”

Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso-occlusive crises

“…Previous studies have observed that episodes of pain can potentially indicate various underlying conditions, including osteomyelitis 41 , stroke 42 , splenic sequestration 43 , and, notably, ACS, as seen in our study. To investigate this, we conducted a comparison of the admission and discharge diagnoses of patients (Fig.…”