“…In addition, 11% of the general population of patients with SCD have a history of overt stroke, as compared to 18.7% in this sample (Quinn, 2013). Furthermore, 37% of the general population of patients with SCD have a history of silent stroke, and only 4% of this study sample had a history of silent stroke (Quinn, 2013).…”
Section: Sample Biasmentioning
confidence: 63%
“…Furthermore, 37% of the general population of patients with SCD have a history of silent stroke, and only 4% of this study sample had a history of silent stroke (Quinn, 2013). Thus, this sample had a larger percentage of patients with overt stroke; and, this sample also had a smaller percentage of patients with silent stroke.…”
Section: Sample Biasmentioning
confidence: 78%
“…These patients are also more likely to receive blood transfusion and hydroxyurea therapy, the only approved medication for prevention of complications in SCD with multiple beneficial effects with patients with SCD (Quinn, 2013;Steinberg, 2011). …”
“…In addition, 11% of the general population of patients with SCD have a history of overt stroke, as compared to 18.7% in this sample (Quinn, 2013). Furthermore, 37% of the general population of patients with SCD have a history of silent stroke, and only 4% of this study sample had a history of silent stroke (Quinn, 2013).…”
Section: Sample Biasmentioning
confidence: 63%
“…Furthermore, 37% of the general population of patients with SCD have a history of silent stroke, and only 4% of this study sample had a history of silent stroke (Quinn, 2013). Thus, this sample had a larger percentage of patients with overt stroke; and, this sample also had a smaller percentage of patients with silent stroke.…”
Section: Sample Biasmentioning
confidence: 78%
“…These patients are also more likely to receive blood transfusion and hydroxyurea therapy, the only approved medication for prevention of complications in SCD with multiple beneficial effects with patients with SCD (Quinn, 2013;Steinberg, 2011). …”
“…Vaccination against H. influenzae type b is also critical due to hyposplenism. Hepatitis B virus and yearly influenza vaccines are also prudent [48, 49]. …”
Section: Sickle Cell Diseasementioning
confidence: 99%
“…Pre-operative simple transfusion has been shown to prevent post-operative ACS. Prior ACS, younger age, and asthma are known risk factors for the development of ACS in general [48, 65]. …”
Thalassemia and sickle cell disease (SCD) are disorders of hemoglobin that affect millions of people worldwide. The carrier states for these diseases arose as common, balanced polymorphisms during human history because they afforded protection against severe forms of malaria. These complex, multisystem diseases are reviewed here with a focus on current standards of clinical management and recent research findings. The importance of a comprehensive, multidisciplinary and lifelong system of care is also emphasized.
These data suggest that the majority of parents and adolescents are willing to accept the current risks associated with matched sibling HSCT for SCA. However, there continue to be significant numbers of parents and adolescents who are unwilling to accept any risk of HSCT-associated mortality or GVHD.
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