2002
DOI: 10.1080/1042819022386833
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Sickle Cell Anemia and Hematological Neoplasias

Abstract: Sickle cell disease (SCD) is a congenital hemolytic anemia with various clinical findings. In some cases hematological neoplasias and some solid tumors may accompany this disease but these have rarely been reported. Here we report five cases with SCD and accompanying hematological neoplasias including lymphoblastic lymphoma, multiple myeloma and hairy cell leukemia in four cases with sickle cell trait and one case of Hodgkin' disease in sickle cell anemia. All of the cases except one had no previously diagnose… Show more

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Cited by 21 publications
(27 citation statements)
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“…The study shows that distortion of cells containing Hb is the result of Hb polymerization. Deoxy HbS polymers in the cell exist in a spectrum of forms from scattered individual fibers to highly ordered fibroid aggregate that essentially filled the cell and distorted it into the classic sickle cell or other elongated form [1][2][3][4][5]. Here, we have reported the association of hematological malignancies and SCD in our region.…”
Section: Introductionmentioning
confidence: 82%
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“…The study shows that distortion of cells containing Hb is the result of Hb polymerization. Deoxy HbS polymers in the cell exist in a spectrum of forms from scattered individual fibers to highly ordered fibroid aggregate that essentially filled the cell and distorted it into the classic sickle cell or other elongated form [1][2][3][4][5]. Here, we have reported the association of hematological malignancies and SCD in our region.…”
Section: Introductionmentioning
confidence: 82%
“…This mutation is not oncogenic directly, sickle cell diseases (SCD), are mostly HbSS and HbC or thalassemia. SCD involves multiple system and manifested by variable degree of anemia, acute vasoocclusive episodes, and chronic organ damage [2]. SCD is associated with high degree of proliferation of bone marrow (BM) cells, chronic inflammation, and immune dysregulation.…”
Section: Introductionmentioning
confidence: 99%
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“…[2][3][4] Many of these malignancies may benefit from autologous hematopoietic stem cell transplantation. However, filgrastim administered to mobilize hematopoietic stem cells may precipitate severe and sometimes fatal sickle crisis in patients with sickle-cell anemia or complex sickle-cell hemoglobinopathies.…”
mentioning
confidence: 99%
“…There are reports of patients with sickle cell disease who developed hematological malignancies such as acute myeloblastic leukemia, multiple myeloma, malignant histiocytosis, Hodgkin lymphoma, and non-Hodgkin lymphoma [1][2][3][4][5][6]. However, the relationship between these malignancies and sickle cell disease is not yet defined and the number of cases reported so far is few.…”
mentioning
confidence: 99%