Incidence of Hematological Malignancies in Sickle Cell Patients From an Indian Tertiary Care Teaching Hospital

Chauhan, Sima; Swain, Santosh Kumar; Sahu, Mahesh Chandra

doi:10.22159/ajpcr.2018.v11i3.22790

Cited by 3 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predominance of AML subtype among these patients is in support of suggestion of increased risk for AML among SCD patients and previous studies done in the same hospital which showed that AML was commoner than ALL 5 , 15 . The predominance of AML among the patients may be attributed to the age distribution of the patients in which AML rather than ALL is commoner.…”

Section: Discussionsupporting

confidence: 85%

“…Lack of folic acid can affect the genetic and epigenetic integrity of p53, which is a well-characterized tumour suppressor 12 . In folic acid replete, 5 , 10 -Methylenetetrahydrofolate derived from folic acid ingestion donates a methyl group to uracil, converting it to thymine, which is used for DNA synthesis and repair. If folate is limited, imbalances in the DNA precursor pool occur, and uracil may be misincorporated into DNA.…”

Section: Discussionmentioning

confidence: 99%

“…Acute leukaemias are malignant clonal diseases in which there is unregulated proliferation, expansion and accumulation of immature leukocytes in bone marrow and blood with suppression of normal haemopoiesis. The accumulation of multiple genetic abnormalities over years, due to a high degree of proliferative activity of BM cells in sickle cell disease may increase the risk for haematological cancer 5 . Acute leukaemias are classified according to lineage into lymphoid, myeloid and occasionally mixed leukaemia.…”

Section: Introductionmentioning

confidence: 99%

“…The accumulation of multiple genetic abnormalities over years, due to a high degree of proliferative activity of BM cells in sickle cell disease may increase the risk for haematological cancer 5 . Acute leukaemias are classified according to lineage into lymphoid, myeloid and occasionally mixed leukaemia.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series

Aworanti¹,

Fasola²,

Kotila³

et al. 2020

Afr H. Sci.

View full text Add to dashboard Cite

Background and objectives: Sickle cell disease(SCD) is a disorder of red cells resulting from the co-inheritance of hae- moglobin S (HbS) with another abnormal haemoglobin. The diagnosis of acute leukaemia is uncommon in our patients with sickle cell disease more so the patients have high morbidity and mortality due to the sickling process.Acute leukemia is a malignant clonal disorder of haemopoietic precursor cells resulting in accumulation of immature blood cells in the bone marrow and blood.The objective of the case series was to highlight the challenges of diagnosis and management of SCD patients with acute leukaemia, the importance of peripheral blood film review and propound a possible risk factor. Methods: Records of 58 patients diagnosed and managed for acute leukaemia over a 7 year period at the University College Hospital, Ibadan were reviewed. The diagnosis of acute leukaemia was based on clinical features in addition to peripheral and bone marrow smears findings. Microsoft excel version 2013 was used for statistical analysis. Results: Five (8.6%) of the patients with acute leukaemia also had sickle cell disease: 3 males and 2 females were described. Recurrent fever and anaemia were the most consistent presenting features in the patients. All the patients were not on any routine medications meant for SCD patients and had poor history of clinic attendance prior to the diagnosis of acute leu- kaemia. The diagnosis of acute leukaemia was not made until the patients were seen by a haematologist. The principal tool of diagnosis in all the patients was peripheral blood film review. Two patients were discharged against medical advice.The treatment period ranged between one month and one year in the remaining three patients. Conclusion: SCD patients are not exempted from developing acute leukaemias and the diagnoses of the two conditions overwhelms the social and economic support of patients and care givers.The study also underscores the relevance of high level of suspicion and prompt review of peripheral blood film of SCD patients particularly when patients present with un- remitting symptoms associated with anaemia and fever. Keywords: Acute leukaemia; sickle cell disease; anaemia.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series

Aworanti¹,

Fasola²,

Kotila³

et al. 2020

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

Sickle cell disease and acute leukemia: one case report and an extensive review

et al. 2023

View full text Add to dashboard Cite

Population-based studies and case reports suggest that there may be an increased risk of acute leukemia associated with sickle cell disease (SCD). Following the description of a new case report, an extensive review of the literature identified 51 previously described cases. Most cases study showed myelodysplastic features confirmed, when available, by genetic markers such as chromosome 5 and/or chromosome 7 abnormalities and TP53 gene mutations. The increased risk of leukemogenesis is certainly multifactorial and related to the pathophysiologic mechanisms of the clinical manifestations of SCD. Chronic hemolysis and secondary hemochromatosis may cause increased chronic inflammation, resulting in persistent marrow stress, which could potentially compromise the genomic stability of the hematopoietic stem cells generating genomic damage and somatic mutations over the course of SCD and its treatment, resulting in a clone that led to acute myeloid leukemia.

show abstract

Hydroxycarbamide

2018

Reactions Weekly

View full text Add to dashboard Cite

Incidence of Hematological Malignancies in Sickle Cell Patients From an Indian Tertiary Care Teaching Hospital

Cited by 3 publications

References 16 publications

Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series

Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series

Sickle cell disease and acute leukemia: one case report and an extensive review

Hydroxycarbamide

Contact Info

Product

Resources

About