2020
DOI: 10.4314/ahs.v20i3.36
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Acute leukemia in sickle cell disease patients in a tertiary health facility in Nigeria: a case series

Abstract: Background and objectives: Sickle cell disease(SCD) is a disorder of red cells resulting from the co-inheritance of hae- moglobin S (HbS) with another abnormal haemoglobin. The diagnosis of acute leukaemia is uncommon in our patients with sickle cell disease more so the patients have high morbidity and mortality due to the sickling process.Acute leukemia is a malignant clonal disorder of haemopoietic precursor cells resulting in accumulation of immature blood cells in the bone marrow and blood.The objective of… Show more

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Cited by 7 publications
(12 citation statements)
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References 11 publications
(16 reference statements)
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“…The life expectancy of patients with SCA has improved in recent years owing to advances in management that may be associated with the many cases of malignancies now being reported in these patients. In Nigeria, 8.6% of cases of acute leukemia were associated with sickle cell disease, among which there was only one case of ALL [ 2 ]. Brunson et al .…”
Section: Discussionmentioning
confidence: 99%
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“…The life expectancy of patients with SCA has improved in recent years owing to advances in management that may be associated with the many cases of malignancies now being reported in these patients. In Nigeria, 8.6% of cases of acute leukemia were associated with sickle cell disease, among which there was only one case of ALL [ 2 ]. Brunson et al .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, this is the first report from Nigeria in which cytogenetic and immunophenotype analyses were done in the diagnosis of acute leukemia in any patient with SCD. There is limited utilization of cytogenetics and flow cytometry in the diagnostic workup of acute leukemia patients in Nigeria owing to lack of facilities in most centers [ 2 , 3 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Nigerian authors 35 report a case series on “Acute leukaemia in sickle cell disease patients in a tertiary health facility.” We end this section with a paper on: “Telepathological evaluation of paediatric histological specimens in support of a hospital in Tanzania” 36 . Quite appropriate because resources and capacity are limited but not innovation!…”
Section: Now To Sickle Cell Anaemia and Leukaemiamentioning
confidence: 99%