Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial

Matsui, Takanori; Kojima, Hiroshi; Suzuki, Harumi; Hamajima, Hiroshi; Nakazato, Hiroaki; Ito, Katsuki; Nakao, Akimasa; Sakamoto, Junichi

doi:10.1093/jjco/hyh110

Cited by 26 publications

(20 citation statements)

References 12 publications

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“…Expression of sialyl Lewis a , which is one of the most important molecules of cell surface carbohydrates, was assessed in its putative function as a prognostic marker of aggressive and metastasizing tumor growth. In one of the few randomized studies investigating specimen of 233 patients, this hypothesis was confirmed [31]. The authors concluded that the expression of the sialyl Lewis a antigen may serve as an indicator of the metastatic potential of colon cancer cells, which would strongly predict the prognosis.…”

Section: Tumor Mobility Invasion and Metastasismentioning

confidence: 84%

Links between Biology, Prognosis and Prediction of Response to Chemotherapy in Colorectal Cancer

Mader

2006

Oncol Res Treat

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Compared with the progress achieved in breast cancer, the use of prognostic and predictive parameters in colorectal cancer is lagging behind. One of the reasons is the limited information provided by ‘classic’ mutations as markers for response to therapy. To bridge this gap, prospective clinical trials need to be conducted to evaluate the usefulness of gene expression profiling and candidate markers, such as DNA repair proteins, onset of the methylator phenotype, neo-angiogenetic pathways related to inflammation, matrix metalloproteinases, tumor suppressors and cell signaling pathways (e.g. Akt). In parallel, the unrivalled sensitivity of molecular techniques may be applied to diagnostic parameters, such as cytokeratin 20 mRNA, for the detection of lymph node metastases. This article reviews the current knowledge on prognostic and predictive parameters in order to highlight the close link between tumor biology and tumor pharmacology. The increasing number of candidate markers together with recently introduced therapeutic options offer novel opportunities for a stepwise approach to the ambitious goal of individualized therapy in colorectal cancer.

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Section: Tumor Mobility Invasion and Metastasismentioning

confidence: 84%

Links between Biology, Prognosis and Prediction of Response to Chemotherapy in Colorectal Cancer

Mader

2006

Oncol Res Treat

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“…Sialyl-Lewis a (sLe a ; CA 19-9), a mucin epitope whose levels in CRC correlate with overall survival and disease free survival, may serve as an indicator of metastatic potential [141,151]. It is believed that tumour metastasis and cancer cell arrest in the vasculature is facilitated through the tethering of circulating cancer cells to vascular endothelium through the interaction of molecules such as CD15s, CA 19-9 and CD44 variants on the tumour cell surface and selectins (CD62-P, -L and –E) expressed on endothelial cells, neutrophils, monocytes, NK cells or platelets [152–155].…”

Section: Cancer Cellsmentioning

confidence: 99%

Cell Surface Markers in Colorectal Cancer Prognosis

Belov

Zhou

Christopherson

2010

IJMS

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The classification of colorectal cancers (CRC) is currently based largely on histologically determined tumour characteristics, such as differentiation status and tumour stage, i.e., depth of tumour invasion, involvement of regional lymph nodes and the occurrence of metastatic spread to other organs. These are the conventional prognostic factors for patient survival and often determine the requirement for adjuvant therapy after surgical resection of the primary tumour. However, patients with the same CRC stage can have very different disease-related outcomes. For some, surgical removal of early-stage tumours leads to full recovery, while for others, disease recurrence and metastasis may occur regardless of adjuvant therapy. It is therefore important to understand the molecular processes that lead to disease progression and metastasis and to find more reliable prognostic markers and novel targets for therapy. This review focuses on cell surface proteins that correlate with tumour progression, metastasis and patient outcome, and discusses some of the challenges in finding prognostic protein markers in CRC.

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“…Both, sLe a and sLe x are typical tumor associated carbohydrate antigens and have been implicated with tumor progression and enhanced metastasis formation [40] of different neoplasias including colon and colorectal cancer [41][42][43][44][45][46][47], lung cancer [48][49][50][51], gastric cancer [52,53], pancreatic cancer [54,55], prostate cancer [56,57], and breast cancer [58]. Sialyl Lewis a is a prognostic factor in colon and colorectal cancer whereby increased sLe a levels are associated with a poor prognosis of the afflicted patients [41,42,45].…”

Section: Organ-specific Tumor Spreading Directed By Selectinsmentioning

confidence: 99%

“…Sialyl Lewis a is a prognostic factor in colon and colorectal cancer whereby increased sLe a levels are associated with a poor prognosis of the afflicted patients [41,42,45]. The role of sLe x as a prognostic factor in colorectal cancer remains unclear.…”

Section: Organ-specific Tumor Spreading Directed By Selectinsmentioning

confidence: 99%

Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner

Dittmar

Heyder²,

Gloria-Maercker

et al. 2007

Clin Exp Metastasis

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To date, cancer is still the second most prevalent cause of death after cardiovascular diseases in the industrialized word, whereby the primary cause of cancer is not attributed to primary tumor formation, but rather to the growth of metastases at distant organ sites. For several years it was considered that the well-known phenomenon of organ-specific spreading of tumor cells is mostly a mechanical process either directed passively due to size constraints (mechanical trapping theory) or due to a fertile environment provided by the organ in which tumor cells can proliferate (seed and soil hypothesis). Both mechanisms strongly depend on the adhesive properties of tumor cells either to endothelial cells and/or cancer cells, which are facilitated by a variety of cell adhesion molecules including carbohydrates and integrins. Within the past years it became evident that the organ-specific metastatic spreading of tumor cells does not only rely on heterotypic and homotypic adhesive interactions, but also on the interplay of chemokines and their appropriate receptors. Moreover, the identification of cancer stem cells in various tumor tissues has opened new questions. Cancer stem cells possess self-renewal, differentiation, and tumor-initiating capacities. Thus these cells are ideal candidates to be the seed of a secondary tumor. In the present review we will give a brief overview about the complex process of organ-specific metastasis formation depending on the interplay of adhesion molecules, chemokines, and the putative role of cancer stem cells in metastasis formation.

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Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial

Abstract: This prospective study in a randomized controlled trial suggests that sialyl Lewis(a) expression levels may serve as an indicator of the metastatic potential of colon cancer cells, which would strongly predict the prognosis.

Cited by 26 publications

References 12 publications

Links between Biology, Prognosis and Prediction of Response to Chemotherapy in Colorectal Cancer

Links between Biology, Prognosis and Prediction of Response to Chemotherapy in Colorectal Cancer

Cell Surface Markers in Colorectal Cancer Prognosis

Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner

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