Sialolipoma of the Salivary Gland: Two New Cases, Literature Review, and Histogenetic Hypothesis

Akrish, Sharon; Leiser, Yoav; Shamira, Dror; Peled, Micha

doi:10.1016/j.joms.2010.05.010

Cited by 31 publications

(36 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sialolipoma is characteristically composed predominantly of adipose tissue with admixed islands of salivary gland acini, ductal, myoepithelial and basal cells [32]. The epithelial/myoepithelial elements may show focal oncocytic change in some cases [32][33][34][35], but unlike oncocytic lipoadenoma, sialolipoma in general lacks a prominent oncocytic component. The tumor tends to show lobulation with evenly distributed salivary gland elements within the fat.…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

View full text Add to dashboard Cite

Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.

show abstract

Section: Discussionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Nagao [7] suggested that there was entrappment of glandular component within the lobules of adipose tissue and the pathogenesis was of non-neoplastic nature. Later on Akrish et al, [8] came up with other hypothesis saying that a dysfunction of a salivary gland leading to modification of function of salivary gland could lead to the tumorigenesis, supporting it with findings such as absence of recurrence, prolonged natural history, histological features of duct ectasia, periductal fibrosis, oncocytic metaplasia, replacement of normal salivary gland tissue with adipose tissue as well as the chronic inflammatory infiltrate. On…”

Section: Discussionmentioning

confidence: 85%

Oncocytic Lipoadenoma of Submandibular Gland: A Case Report

Parmar¹

2015

JCDR

View full text Add to dashboard Cite

A 45-year-old gentleman presented to ENT outpatient clinic, Christian Medical College, Vellore, India with complaints of gradually progressive, painless, left sided neck swelling since past one year. It had increased in size over the past two months. There was no history of dryness of mouth, no intraoral discharge,dysphagia, fever, loss of weight or appetite or any comorbid medical illness. Neck examination revealed a 5 x 6 cm, well-defined, mass below the left angle of mandible with smooth surface and without any scars or sinuses over it. On palpation, the inspectory findings were confirmed. The swelling was non-tender, having well-defined borders with soft to firm consistency and was not fixed to overlying skin. There were no palpable lymph nodes in the neck. There was no intraoral swelling on bimanual examination. Based on these clinical findings a clinical diagnosis of salivary gland neoplasm was made, FNAC of the swelling was done but was inadequate for proper evaluation. Other possibilities of a soft tissue tumour and rare low grade lymphoma were kept in mind. Sialography was not indicated in this case and hence it was not carried out. Ct FindingsLeft salivary gland was enlarged with a large fatty lesion, 55mm x 45mm x 20mm, having a large mural component. Lesion had solid component in it measuring approximately 27 x 17 mm. with a few mottled densities [Table/ Fig-1]. There was no significant Pathology SectionOncocytic Lipoadenoma of Submandibular Gland: A Case Report lymphadenopathy. Surgery was done under general anaesthesia. Patient was positioned on a shoulder roll with head tilted to right side. Painting with betadine lotion was done followed by drapping. The incision was made in the skin crease 5cm below the angle of mandible and deepened through platysma. Both superficial and deep lobes were identified with preservation of mandibular nerve and hypoglossal nerve with ligation of facial artery and facial vein. A 5 × 5 cm large mass arising from the left submandibular gland was excised and submitted for histopathological examination. After securing complete hemostasis, cervical fascia and skin flaps were sutured back in position. Grossly, the tumour was lobulated, encapsulated mass with well-defined brown areas and adjacent greasy-yellow soft areas [Table/ Fig-2]. Histopathology examination revealed circumscribed tumour composed of lobules and sheets of oncocytes [Table /Fig-3,4]. Also, present were sheets and lobules of mature adipocytes, some of which are entrapped by the oncocytic nodules [Table /Fig-3,4]. There was patchy periductal chronic inflammation and fibrosis. There was focal sebaceous metaplasia at the edges of oncocytic nodules [Table/ Fig-5]. There was no evidence of lymphovascular or perineurial invasion or any extra capsular invasion. Immunohistochemistry was not indicated in this case due to obvious morphological findings, which were consistent with those mentioned in the literature. On a telephonic follow up, no recurrence of symptoms so far. Patient is due for a yearly follow-up duri...

show abstract

“…It has been hypothesised by Akrish and others (2011) that sialolipoma may result from salivary gland dysfunction due to the replacement of salivary gland parenchyma with mature adipose tissue and varying stages of acinar atrophy; with the presence of salivary duct long-standing changes, such as ectasia, periductal fibrosis and/or oncocytic metaplasia; and moderate to severe chronic inflammatory infiltrate, as it is described in case 2.…”

Section: Discussionmentioning

confidence: 97%

Sialolipoma of the parotid salivary gland in two dogs

Tilve

Finck

Leach

et al. 2017

Vet Record Case Reports

View full text Add to dashboard Cite

An eight-year-old male neutered boxer and a 10-year-old female neutered lurcher were presented with palpable masses in the region of the right parotid salivary gland. In both cases, fine needle aspirates yielded adipose cells, normal salivary epithelium and some blood contamination. CT images showed a mixed fat attenuating mass in the region of the right parotid salivary gland, without a normal ipsilateral parotid salivary gland. Surgical excision was performed in both cases and histopathology was consistent with sialolipoma. Neither mass has recurred 7 and 16 months after surgery. Sialolipoma should therefore be considered as a differential in dogs with a mass in this location. Fine needle aspirates showing salivary epithelium and adipose cells should not be dismissed as non-diagnostic. To the authors’ knowledge, these are the two first reported cases of sialolipomas of the parotid salivary gland in dogs and the first description of cross-sectional imaging of sialolipomas.

show abstract

Sialolipoma of the Salivary Gland: Two New Cases, Literature Review, and Histogenetic Hypothesis

Cited by 31 publications

References 16 publications

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Oncocytic Lipoadenoma of Submandibular Gland: A Case Report

Sialolipoma of the parotid salivary gland in two dogs

Contact Info

Product

Resources

About