Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Abstract

Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.

A case of oncocytic lipoadenoma of the submandibular gland and its diagnostic cytology challenges

“…1 Oncocytic lipoadenoma is a very rare benign tumor of the salivary gland that was first described by Hirokawa et al 4 After that, few other cases of oncocytic lipoadenoma have been reported; most of those reported cases were arising in the parotid gland with only four cases reported to occur in the submandibular gland. [3][4][5][6][7][8][9][10] Our patient presented with a swelling at the right angle of mandible which revealed by ultrasound that it was arising from the subman- In summary, we are reporting a rare case of oncocytic lipoadenoma arising in the submandibular gland. Our aim is to upsurge awareness among cytopathologists during preoperative evaluation of oncocytic salivary gland lesions.…”

“…Oncocytic lipoadenoma is a very rare benign tumor of the salivary gland that was first described by Hirokawa et al After that, few other cases of oncocytic lipoadenoma have been reported; most of those reported cases were arising in the parotid gland with only four cases reported to occur in the submandibular gland …”

“…The former has been included in the recent World Health Organization (WHO) classification of head and neck tumors; however, oncocytic lipoadenoma is still not . To date, few cases of oncocytic lipoadenoma have been reported in the English literature, most of those cases were located in the parotid gland with only four cases reported to arise from the submandibular gland . Herein, we report another case of oncocytic lipoadenoma in the submandibular gland and try to shed some light on its diagnostic challenges during cytologic examination.…”

“…[1][2][3] To date, few cases of oncocytic lipoadenoma have been reported in the English literature, most of those cases were located in the parotid gland with only four cases reported to arise from the submandibular gland. [3][4][5][6][7][8][9][10] Herein, we report another case of oncocytic lipoadenoma in the submandibular gland and try to shed some light on its diagnostic challenges during cytologic examination.…”

Oncocytic osteolipoadenoma of the submandibular gland

“…Our review of the English‐language literature identified 29 previous oncocytic lipoadenomas of the salivary glands . There were 17 males (59%) and 12 females (41%), with an average age of 57 years (range 7–89 years).…”