Sialic Acid As A Potential Biomarker for Cardiovascular Disease, Diabetes and Cancer

Cheeseman, Jack; Kuhnle, Gunter Georg; Stafford, Graham P.; Gardner, Richard A.; Spencer, Daniel I. R.; Osborn, Helen M. I.

doi:10.2217/bmm-2020-0776

Cited by 15 publications

(19 citation statements)

References 74 publications

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“…354 A study by Cheeseman et al revealed that elevated concentrations of sialic acids in plasma and serum correlated positively with the presence of CVD, diabetes, and the development of malignant tumors. 344 Another study by Laider et al found a significant correlation between increased α2,6sialylation and adhesion abilities of metastatic melanoma cells. 355 In line with these observations, Kremser et al, identified an altered N-glycome by MALDI-MS on integrins α3β1 and α5β3 and revealed that glycan modifications have been related with increased melanoma cell motility, impacting cell−ECM interactions.…”

Section: Ht-glycomics In Clinical Studiesmentioning

confidence: 96%

“…Recently, glycobiology has gained importance in cancer research given its role in understanding various cancer mechanisms and for diagnostic application. − Also, advances in the field of proteomics and glycomics have helped glycobiologists decipher the link between glycan structures and disease progression . Glycosylation acts as a key regulatory mechanism, controlling several physiopathological processes and defects in glycosylation are associated with various diseases, including cancers. ,− While glycoproteins are some of the most common clinically used biomarkers for diagnosis and monitoring of malignant progression, their glycosylation has not, yet, been taken into account. ,− However, it has been widely shown that glycosylation changes can be associated with cancer, of which most are related to sialylation, fucosylation, mucin-type O -glycans, as well as N - and O -linked glycan branching. ,, …”

Section: Applicationsmentioning

confidence: 99%

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High-Throughput Glycomic Methods

et al. 2022

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Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and potentially automatable analytical technologies for the analysis of hundreds or thousands of glycomes in a timely manner (termed high-throughput glycomics). This review provides a historic overview as well as highlights recent developments and challenges of glycomic profiling by the most prominent high-throughput glycomic approaches, with N-glycosylation analysis as the focal point. It describes the current state-of-the-art regarding levels of characterization and most widely used technologies, selected applications of high-throughput glycomics in deciphering glycosylation process in healthy and disease states, as well as future perspectives.

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Section: Ht-glycomics In Clinical Studiesmentioning

confidence: 96%

Section: Applicationsmentioning

confidence: 99%

High-Throughput Glycomic Methods

et al. 2022

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“…Both mutations have been shown to increase sialyltransferase activity in vitro, possibly in vivo. Increased sialyltransferase activity in blood cells and serum sialic acid levels are associated with atherosclerosis and CAD [ 64 ]. Some studies in the United States have provided statistically significant additional evidence for the potential contribution of ST6GALNAC5 gene mutations to the occurrence of CAD [ 63 ].…”

Section: Monogenic Etiology Of Cad/mimentioning

confidence: 99%

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

Butnariu

Florea

Bădescu

et al. 2022

Life

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In the modern era, coronary artery disease (CAD) has become the most common form of heart disease and, due to the severity of its clinical manifestations and its acute complications, is a major cause of morbidity and mortality worldwide. The phenotypic variability of CAD is correlated with the complex etiology, multifactorial (caused by the interaction of genetic and environmental factors) but also monogenic. The purpose of this review is to present the genetic factors involved in the etiology of CAD and their relationship to the pathogenic mechanisms of the disease. Method: we analyzed data from the literature, starting with candidate gene-based association studies, then continuing with extensive association studies such as Genome-Wide Association Studies (GWAS) and Whole Exome Sequencing (WES). The results of these studies revealed that the number of genetic factors involved in CAD etiology is impressive. The identification of new genetic factors through GWASs offers new perspectives on understanding the complex pathophysiological mechanisms that determine CAD. In conclusion, deciphering the genetic architecture of CAD by extended genomic analysis (GWAS/WES) will establish new therapeutic targets and lead to the development of new treatments. The identification of individuals at high risk for CAD using polygenic risk scores (PRS) will allow early prophylactic measures and personalized therapy to improve their prognosis.

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“…[14,16] Neu5Ac has previously been identified as a biomarker for cancer, diabetes and cardiovascular diseases. [17] Overexpression of sialic acid has been detected on the endothelium when cardiovascular disease (CVD) and therefore inflammation is present. There is a significant elevation in sialic acid in plasma and serum samples between healthy controls and disease patients.…”

Section: Introductionmentioning

confidence: 99%

“…Neu5Ac has previously been identified as a biomarker for cancer, diabetes and cardiovascular diseases [17] . Overexpression of sialic acid has been detected on the endothelium when cardiovascular disease (CVD) and therefore inflammation is present.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Standards of 4‐O‐Acetyl‐ and 9‐O‐Acetyl‐N‐Acetylneuraminic Acid for the Analysis of Plasma and Serum

et al. 2022

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N‐Acetylneuraminic acid (sialic acid, Neu5Ac) is one of a large, diverse family of nine‐carbon monosaccharides that play roles in many biological functions such as immune response. Neu5Ac has previously been identified as a potential biomarker for the presence and pathogenesis of cardiovascular disease (CVD), diabetes and cancer. More recent research has highlighted acetylated sialic acid derivatives, specifically Neu5,9Ac2, as biomarkers for oral and breast cancers, but advances in analysis have been hampered due to a lack of commercially available quantitative standards. We report here the synthesis of 9‐O‐ and 4‐O‐acetylated sialic acids (Neu5,9Ac2 and Neu4,5Ac2) with optimisation of previously reported synthetic routes. Neu5,9Ac2 was synthesised in 1 step in 68 % yield. Neu4,5Ac2 was synthesised in 4 steps in 39 % overall yield. Synthesis was followed by analysis of these standards via quantitative NMR (qNMR) spectroscopy. Their utilisation for the identification and quantification of specific acetylated sialic acid derivatives in biological samples is also demonstrated.

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Sialic Acid As A Potential Biomarker for Cardiovascular Disease, Diabetes and Cancer

Cited by 15 publications

References 74 publications

High-Throughput Glycomic Methods

High-Throughput Glycomic Methods

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

Quantitative Standards of 4‐O‐Acetyl‐ and 9‐O‐Acetyl‐N‐Acetylneuraminic Acid for the Analysis of Plasma and Serum

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