Sialadenoma papilliferum: A rare case report and review of literature

Sunil, S; Babu, Sharlene Sara; Panicker, Sathibhai; Pratap, Nithin

doi:10.4103/0973-1482.187300

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…It also presented acanthosis and parakeratosis as described in the literature (38). Some of our findings were also reported in other cases, such as chronic inflamation cells in connective tissue (3,10,12,30), epithelium with hyperkeratosis and parakeratosis (2,3,11,19,20), hyperplastic epithelium (2,19,26), epithelium with focal hypergranulosis (19), and spongiosis in squamous epithelium (19).…”

Section: Discussionsupporting

confidence: 87%

Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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BackgroundSialadenoma papilliferum is a benign rare condition of salivary glands showing a characteristic papillary growth of the ductal epithelium that ends up being confused with more frequent lesions of the oral cavity. Objectives: To perform a bibliometric analysis of all articles about Sialadenoma papilliferum in the oral cavity and to add a singular case report of Sialadenoma in the lower lip.Material and MethodsA total of 36 publications referring to Sialadenoma papilliferum in the oral cavity from the PubMed platform was reviewed. The specific data were collected, and a bibliometric analysis was performed using Microsoft Excel. The results obtained were then compared with this new case report.ResultsThe people most affected with sialadenoma were white males at the average age of 56. The lesion was asymptomatic, usually white or red, with an average size of 1.4 cm, and the palate was by far the most affected site. The majority of the lesions were excised, and only two cases indicated recurrence.ConclusionsWith surgical removal, Sialadenoma papilliferum has a favorable prognosis and no further treatment is required. Due to few recorded cases of recurrence, a long follow-up period is recommended to ensure that the lesion does not redevelop. Key words:Sialadenoma papilliferum, salivary gland, oral cavity, bibliometric analysis.

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Section: Discussionsupporting

confidence: 87%

Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos¹,

Gerber²,

Saraiva³

et al. 2019

J Clin Exp Dent

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show abstract

“…Although there have been a few reports of recurrence and malignant transformation, in which SP has reported that it can transformed into epithelial-muscle epithelial carcinoma, squamous cell carcinoma, and mucoepidermoid carcinoma, but malignant transformation is rare and not entirely convincing [6,16,32,47]. As the results of the statistics show that the prognosis of this lesion is very good, we believe that SP does not have malignant potential [14,44,48].…”

Section: Discussionmentioning

confidence: 91%

“…It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus [2,3,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [3,[32][33][34][35][36][37][38][39][40][41][42][43]. Grossly, most of the lesions presents as a round to oval mass with whitecolored and papillary surface, sharing about 80%.…”

Section: Discussionmentioning

confidence: 99%

“…It's worth noting that we found out some oncocytic changes in accidental areas of the tumour, just as Hsieh and colleagues reported in 2020 [3,5], which they named the oncocytic SP relative to the classic SP. Furthermore, the mucosal surface of most cases has many papillary projections supported by fibrovascular connective tissue core, while a few cases only formed numerous micropapillae without a central fibrovascular core [32,44].…”

Section: Discussionmentioning

confidence: 99%

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Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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Background Sialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and five new cases. Methods The clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further performed and the related literatures were reviewed and analyzed. Results Combining 89 cases from the literature with our cases, the hard palate was the most common locations for SP. However, two of our cases were rarely located in the esophageal mucosa. Among all cases, the male gender was more affected, with the average age and median age of 61.8 and 62 years, respectively. Conventional histomorphologically, SP was characterized by complex papillary structures with a biphasic growth pattern of exophytic squamous component and endophytic glandular component. The glandular structures were lined by a double layer of epithelium composed of flattened or cuboidal basal cells and a cuboidal or columnar luminal cells formed papillary infoldings into the ductal lumina. Immunohistochemically, the luminal epithelial configurations showed strong expression of CK7 along the luminal cell membrane, while the basal myoepithelia displayed strong nuclear p63 expression. In both the glandular and squamous tumour components showed BRAF V600E-positive immunostaining and BRAF V600E mutation. Conclusion For the first time, we have comprehensively aggregated and analyzed 90 cases sialadenoma papilliferum from almost all previous publications, and further explored the clinicopathological features of SP; concordantly, this study demonstrated that SP shows a papillomatous growth pattern with exophytic and endophytic proliferation of ductal epithelium composed of double-layered cells harboring BRAF V600E mutation. Additionly, adequate treatment for SP is surgical excision, with a favorable prognosis in patients.

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“…It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus 2,4,10,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] . Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [31][32][33][34][35][36][37][38][39][40][41] . Grossly, most of the lesions presents as a round to oval mass with white-colored and papillary surface, sharing about 80 percent.…”

Section: Discussionmentioning

confidence: 99%

Sialadenoma Papilliferum: With Clinicopathologic, Immunohistochemical, Molecular Analysis, and Review of the Literature

Chen

Peng

Yuan

et al. 2021

Preprint

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BackgroundSialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 65 cases previously reported and five new cases.Materials and methodsThe clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further performed and the related literatures were reviewed and analyzed. ResultsCombining 65 cases from the literature with our cases, the hard palate was the most common locations for SP. However, two of our cases were rarely located in the esophageal mucosa. Among all cases, the male gender was more affected, with the average age and median age of 58 and 59 years, respectively. Conventional histomorphologically, SP was characterized by complex papillary structures with a biphasic growth pattern of exophytic squamous component and endophytic glandular component. The glandular structures were lined by a double layer epithelium composed of flattened or cuboidal basal cells and a cuboidal or columnar luminal cells formed papillary infoldings into the ductal lumina. Immunohistochemically, the luminal epithelial configurations showed strong expression of CK7 along the luminal cell membrane, while the basal myoepithelia displayed strong nuclear p63 expression. In both the glandular and squamous tumor components showed BRAF V600E-positive immunostaining and BRAF V600E mutation. ConclusionFor the first time, we have comprehensively aggregated and analyzed 66 cases sialadenoma papilliferum from almost all previous publications, and further explored the clinicopathological features of SP; concordantly, this study demonstrated that SP shows a papillomatous growth pattern with exophytic and endophytic proliferation of ductal epithelium composed of double-layered cells harboring BRAF V600E mutation. Additionly, adequate treatment for SP is surgical excision, with a favorable prognosis in patients.

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Sialadenoma papilliferum: A rare case report and review of literature

Cited by 7 publications

References 2 publications

Sialadenoma papilliferum: Bibliometric analysis

Sialadenoma papilliferum: Bibliometric analysis

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma Papilliferum: With Clinicopathologic, Immunohistochemical, Molecular Analysis, and Review of the Literature

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