Sialadenoma papilliferum: Bibliometric analysis

Vasconcelos, Antonio-Jorge-Araújo de; Gerber, Luana-Rafaela; Saraiva, Stanny-Hagath-Maciel; Vasconcelos, Pâmela-Oliveira de; Cabral, L.A. Guimaraes; Pinheiro, Tiago Novaes

doi:10.4317/jced.56055

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…2 SP commonly occurs on the palate and clinically can be easily misdiagnosed for squamous papilloma or verrucous hyperplasia. 4,7 These recent findings reinforce the functional role of the RAS/mitogen-activated protein kinase signaling pathway in the pathogenesis of ductal papillomas of the salivary glands. Thus, we investigated the presence of the BRAF V600E mutation in SP of the minor salivary glands using an anti-BRAF V600E monoclonal antibody (VE1 clone).…”

Section: Introductionsupporting

confidence: 56%

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Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis

et al. 2023

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Introduction. Sialadenoma papilliferum (SP) is a rare benign neoplasm that usually arises in the minor salivary glands. Recently, it was demonstrated that SP shares similar molecular genetic alterations ( BRAF V600E or HRAS mutations) with its morphologic analog, syringocystadenoma papilliferum. Methods. We sought to perform clinicopathologic and immunophenotypic (BRAF V600E and SOX10) analyses on 8 new cases of SP. Results. The cases were from 4 males and 4 females, with ages ranging from 28 to 81 years (average: 64 years). The common locations were the hard palate (n = 3) and buccal mucosa (n = 3). Histopathologically, 7 cases were classic and 1 case was oncocytic. BRAF V600E immunohistochemistry (IHC) was positive in all classic SP, involving both the exophytic and endophytic components, but negative in the oncocytic SP. SOX10 was positive in the endophytic ductal cells of the evaluated classic SP but was negative in the oncocytic SP. Conclusions. We report 8 new cases of this rare salivary gland neoplasm, using BRAF V600E and SOX10 IHC to further support the following points: (1) the functional role of BRAF V600E mutation, RAS/mitogen-activated protein kinase signaling pathway in the pathogenesis of classic SP of salivary glands by IHC; (2) the analogous relationship between SP, syringocystadenoma papilliferum, and papillary seromucinous adenocarcinoma with sinonasal papilloma-like surface component (PSASP-like surface); (3) endophytic ductal component in classic SP arises from the intercalated ducts and not the excretory ducts; and (4) oncocytic SP is distinct from classic SP.

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Section: Introductionsupporting

confidence: 56%

“…2 SP commonly occurs on the palate and clinically can be easily misdiagnosed for squamous papilloma or verrucous hyperplasia. 4,7…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis

et al. 2023

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“…Despite the similar clinical features of SialP and papillary lesions of the squamous mucosa such as SqP, histological discrimination is generally not a problem because of the submucosal glandular proliferation in addition to the common squamous papillary growth (7,(9)(10)(11). The problem is that SqP arising in the salivary gland duct orifice, the opening, can pathologically mimic SialP, confusing the pathologist and leading to misdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Papillary Lesions at the Mouth Floor May Mimic Sialadenoma Papilliferum

Han¹,

Cho²,

Park³

et al. 2022

Pathol. Oncol. Res.

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Salivary gland tumor Sialadenoma papilliferum (SialP) clinically resembles papillary epithelial lesions, such as squamous papilloma (SqP) or verrucous leukoplakia. Pathological sampling including an adequate depth of both the mucosa and submucosa layer is required for discrimination between the diseases. Though ductal proliferation in the submucosa is characteristic in SialP, papillary lesions arising at the mouth floor, specifically near the ductal orifice, are more problematic. Salivary gland ductal ectasia, along with the overlying papillary hyperplasia, may mimic the biphasic tumorous growth pattern of SialP, making discrimination extremely difficult. Further cellular dysplasia in the papillary mucosal lesion raises the possibility of malignant transformation in a known benign lesion, SialP. Herein, we present a case of SqP at the mouth floor which mimicked both clinical and pathological features of SialP and compared it with a definite case of SialP. Moreover, we discuss major differential points that clinicians and pathologists should consider during diagnosis of oral papillary lesions arising near the salivary glands.

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“…Nevertheless, malignant transformation of salivary SP has been described in some case reports. 13,14…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Patients were followed‐up for 6 to 122 months; no recurrence or progression was observed in any patients, suggesting that pulmonary SP primarily demonstrates a benign clinical course. Nevertheless, malignant transformation of salivary SP has been described in some case reports 13,14 …”

Section: Clinical Featuresmentioning

confidence: 99%

Pulmonary sialadenoma papilliferum and its mimics: what you need to know

Gao

Sun

2022

Histopathology

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Pumonary salivary gland‐type tumours (SGT) represent a small but distinct group of primary lung neoplasms. These types of tumours originate from the submucosal bronchial glands of the tracheobronchial tree. Pulmonary SGTs differ greatly in the incidence of individual tumours from salivary gland tumours of the head and neck. Additionally, the vast majority of pulmonary SGT are malignant. Recently, pathological diagnosis has significantly improved with the application of molecular diagnostic technologies. However, the current knowledge of benign SGTs is limited; moreover, tumour diversity and overlapping morphological features of SGT represent diagnostic challenges such as correct tumour categorisation and their accurate differentiation from malignant lesions. Compounding this inherent difficulty has been the recent introduction of new variants, including sialadenoma papilliferum (SP). Pulmonary SP is very rare, with limited reports available, and most of the initial diagnoses rendered so far were incorrect, resulting in inappropriate treatment. Several cases of SP have recently been reported. This review will serve to update practicing pathologists on the morphology, immunophenotype and molecular characteristics of SP and its mimics.

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Sialadenoma papilliferum: Bibliometric analysis

Cited by 5 publications

References 36 publications

Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis

Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis

Case Report: Papillary Lesions at the Mouth Floor May Mimic Sialadenoma Papilliferum

Pulmonary sialadenoma papilliferum and its mimics: what you need to know

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