Si–N linkage in ultrabright, ultrasmall Si nanoparticles

Rogozhina, Elena V.; Belomoin, G.; Smith, Audrey; Abuhassan, Laila; Barry, Nicolas P. E.; Akcakir, O.; Nayfeh, Munir H.

doi:10.1063/1.1377619

Cited by 61 publications

(52 citation statements)

References 22 publications

(26 reference statements)

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“…2c). 37 This sample shows a much narrower peak eluting at later R V (24 min) with a PD of 1.1, close to that of the standard. The low PD after functionalization is representative of individual, monodisperse Si-np and indicates that either the starting Si-np-H were not irreversibly aggregated or that the larger Si structures were less reactive and removed during purification.…”

Section: Resultsmentioning

confidence: 99%

“…However, the broadening toward earlier R V (shoulder y22 min) in much more significant after hydrosilylation that it was after chlorination-amination. 37 This may be due to particles that were already aggregated prior to reaction since the starting Si-np-H were seen to be polydisperse (Fig. 2b).…”

Section: Ester Functionalized Si-npmentioning

confidence: 99%

“…For example, alkylated Si-np (Si-C linkage) were synthesized by reduction of chlorosilanes with Na at high pressure and temperature 27 or by reduction of SiCl 4 with NaSi, 28 Mg 2 Si, 29 or Na naphthalenide, 30 followed by reaction with Grignard or alkyl lithium reagents, and by hydrosilylation of 1-alkenes with Si-np-H. [31][32][33] Alkoxylated Si-np (Si-O-C linkage) have been prepared by reducing SiCl 4 with Zintl salts followed by treatment with alcohol, 34 through thermal decomposition of diphenyl silane (SiH 2 Ph 2 ) in supercritical octanol, 35 and by followed by reaction with an alkyl amine, resulting in covalent attachment of alkyl groups through a Si-NH-C linkage. 37 Unfortunately, this route is limited by the chemical instability of the Si-N bond and the chlorinated intermediate. Likewise, the Si-O-C linkage is generally unstable, being subject to reactions such as hydrolysis and cross-linking through Si-O-Si bridges.…”

Section: Introductionmentioning

confidence: 99%

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Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation

et al. 2006

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Functionalization of ultrasmall semiconductor nanoparticles to develop new luminescent probes that are optically bright, stable in aqueous environments, and sized comparably to small organic fluorophores would be of considerable utility for myriad applications in biology. Here, we report one of the first examples of thermal hydrosilylation between a bi-functional alkene and ultrasmall (y1 nm) H-passivated silicon nanoparticles (Si-np-H) to prepare strongly luminescent, water stable, carboxyl functionalized nanoparticles (Si-np-COOH). Nuclear magnetic resonance, infrared absorption spectroscopy (FTIR), size exclusion chromatography (SEC), and photoluminescence spectroscopy are used to characterize the Si-np dispersions. Based on the SEC and FTIR data, a reaction scheme is proposed to account for side products formed through a free radical cross-linking mechanism. The Si-np-COOH may find use in applications such as biomolecular labeling and biological imaging.

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Section: Resultsmentioning

confidence: 99%

Section: Ester Functionalized Si-npmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation

et al. 2006

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“…It has been shown that 1−3 nm size silicon nanoparticles fluoresce in blue, green, and red wavelengths upon excitation with UV illumination. 8,9 Optical vibronic and excitonic properties of these ultrasmall nanoparticles have also been obtained both experimentally and theoretically. 10 Laser ablation synthesis of nanoparticles is another promising solution.…”

Section: Introductionmentioning

confidence: 99%

Post-Treatment of Silicon Nanocrystals Produced by Ultra-Short Pulsed Laser Ablation in Liquid: Toward Blue Luminescent Nanocrystal Generation

2012

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Blue luminescent colloidal silicon nanocrystals (Si-NCs) were produced in a two-stage process. In the first step, synthesis of Si-NCs was achieved by femtosecond pulsed laser ablation of a silicon wafer, which was immersed in deionized water. The size and the structural and the chemical characteristics of colloidal Si-NCs were investigated by TEM and EDAX analyses, and it is found out that the Si-NCs are in spherical shape and the particle diameters are in the range of 5−100 nm. In the second step, ultrasonic waves and filtering chemical-free post-treatment of colloidal Si-NCs solution was performed to reduce the particle size. High-resolution TEM (HRTEM) studies on post-treated colloidal solution clearly show that small (1−5.5 nm in diameter) Si-NCs were successfully produced. Raman spectroscopy results clearly confirms the generation of Si nanoparticles in the crystalline nature, and the Raman scattering study of post-treated Si-NCs confirms the reduction of the particle size. The UV−vis absorption and photoluminescence (PL) spectroscopy studies elucidate the quantum confinement effect of Si-NCs on the optical properties. The colloidal Si-NCs and post-treated Si-NCs solutions present strong absorption edge shifts toward UV region. Broadband PL emission behavior is observed for the initial colloidal Si-NCs, and the PL spectrum of post-treated Si-NCs presents a blue-shifted broadband PL emission behavior due to the particle size reduction effect.

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“…[14][15][16][17] The size tunable emission [18][19][20] , high brightness 21 , and high photostability compared to organic dyes 22 , have made SiNPs attractive materials as fluorescent cellular markers. In addition, silicon is abundant and economical 23 but more importantly silicon has low inherent toxicity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cells

Behray

Webster

Pereira

et al. 2016

ACS Appl. Mater. Interfaces

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ABSTRACT:The novel thiourea-functionalized silicon nanoparticles (SiNPs) have been successfully synthesized using allylamine and sulforaphane, an important anticancer drug, followed by a hydrosilylation reaction on the surface of hydrogen terminated SiNPs. Their physiochemical properties have been investigated by photoluminescence emission, FTIR and elemental analysis. MTT assay has been employed to evaluate in vitro toxicity in colorectal cancer cells (Caco-2) and primary normal cells (CCD). The results show significant toxicity of thiourea SiNPs after 72 h incubation in the cancer cell line and the toxicity is concentration dependent and saturated for concentrations above 100 µg/mL. Confocal microscopy images have demonstrated the internalization of thiourea-functionalized SiNPs inside the cells. Flow cytometry data has confirmed receptor-mediated targeting in cancer cells. This nanocomposite takes advantage of the EGFR active targeting of the ligand in addition to the photoluminescence properties of SiNPs for bioimaging purposes. The results suggest that this novel nanosystem can be extrapolated for active targeting of the receptors that are overexpressed in cancer cells such as EGFR using the targeting characteristics of thiourea-functionalized SiNPs and therefore encourage further investigation and development of anticancer agents specifically exploiting the EGFR inhibitory activity of such nanoparticles.

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Si–N linkage in ultrabright, ultrasmall Si nanoparticles

Cited by 61 publications

References 22 publications

Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation

Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation

Post-Treatment of Silicon Nanocrystals Produced by Ultra-Short Pulsed Laser Ablation in Liquid: Toward Blue Luminescent Nanocrystal Generation

Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cells

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