Shrinking the malaria map: progress and prospects

Feachem, Richard; Phillips, A.; Hwang, Jimee; Cotter, Chris; Wielgosz, Benjamin; Greenwood, Brian; Sabot, Oliver; Rodrı́guez, Mario H.; Abeyasinghe, Rabindra; Ghebreyesus, Tedros Adhanom; Snow, Robert W.

doi:10.1016/s0140-6736(10)61270-6

Cited by 359 publications

(364 citation statements)

References 64 publications

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“…1,2 In recent years, substantial progress has been made in reducing the regional malaria burden; several countries have entered the malaria preelimination and elimination phases. 3 This success is attributed, in part, to the deployment of artemisinin-based combination therapies (ACTs) in malaria-endemic countries. However, the recent emergence and/or spread of artemisinin resistance in Plasmodium falciparum in parts of GMS pose a serious threat to regional malaria control and elimination campaign.…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Dihydroartemisinin–Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China–Myanmar Border

Wang¹,

Yang²,

Yuan³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Artemisinin-based combination therapies (ACTs) are currently used as the first-line therapy for uncomplicated Plasmodium falciparum malaria. However, the recent emergence and/or spread of artemisinin resistance in parts of Greater Mekong Subregion (GMS) of southeast Asia requires close monitoring of the therapeutic efficacy of ACTs. This study was conducted from March 2012 to December 2013 in four clinics and seven villages along the China-Myanmar border. A total of 109 patients with uncomplicated falciparum malaria were treated with dihydroartemisinin-piperaquine (DP) and followed up on days 1, 2, 3, 7, 14, 21, 28, and 42 after treatment. A total of 71 patients (22 children and 49 adults) completed the 42-day follow-up. DP remained highly efficacious for treatment of uncomplicated falciparum malaria with an overall 42-day cure rate of 100%. The day 3 parasite-positive rate was 7.04% (5/71). Within 14 days of treatment, a total of 13 (18.31%) patients had detectable gametocytes and a large proportion of these were persistent from the first three days of treatment. The presence of gametocytes in patients through 14 days after DP treatment suggests that the incorporation of a single dose of primaquine for clearing gametocytemia should be considered for blocking parasite transmission.

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Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Dihydroartemisinin–Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China–Myanmar Border

Wang¹,

Yang²,

Yuan³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Otro grupo de autores, Feachem, et al (61), plantea que para que la eliminación sea posible, se debe adoptar una estrategia en tres partes: control agresivo en regiones de alta endemia, eliminación progresiva desde los márgenes endémicos para reducir el mapa, e investigación y desarrollo en busca de nuevas herramientas y técnicas. Señalan que la eliminación debe ser una decisión de cada país y que cuando éste decida implantar la eliminación sería porque ya tiene una infraestructura respaldando el control.…”

Section: Voces Frente a La Eliminaciónunclassified

“…Los países que ya han logrado el control con baja endemia se enfrentan al dilema de si erradicar o no. Ellos deben tener la capacidad de calcular el costo del control comparativamente con el costo de la eliminación y de mantenerla (61)(62)(63)(64).…”

Section: Voces Frente a La Eliminaciónunclassified

Challenges for the elimination of malaria in Colombia: A problem of knowledge or of power

Blair

2012

biomedica

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Introducción. Las prácticas para eliminar la malaria en el mundo han pasado de los programas de control sanitario, conocidos en Colombia como la "lucha higiénica" en los primeros años del siglo XX, a la erradicación en los años 50 y de vuelta al control en 1978. Hoy, después de 43 años de haber fracasado el Programa Mundial de Erradicación, la Organización Mundial de la Salud propone a los países miembro adoptar como meta un programa de eliminación con miras a la erradicación. ¿Será esto posible en Colombia? Objetivo. Revisar las posibilidades de eliminación de la malaria en Colombia desde un análisis histórico del saber y de las prácticas que se desarrollaron para lograrlo. Resultados. Se presentan los obstáculos y las posibilidades para el desarrollo de un programa de eliminación de la malaria en Colombia, donde el modelo etiopatogénico de sufrir una enfermedad infecciosa, basado en la teoría microbiana, sigue vigente y respalda prácticas como la erradicación. Conclusiones. La eliminación de la malaria es no sólo un problema de saber científico, de vacíos en el conocimientos sobre el objeto mismo, sino una forma de sustentar ese conocimiento en una única teoría, la microbiana o la etiopatogénica, para explicar enfermedades como la malaria, y también, un problema de poder; aun cuando el poder político puede ser una forma de saber, se entiende con esto la mezcla de estrategias y de intereses de las instituciones que dictan las políticas públicas, las agencias internacionales, los que venden insecticidas y medicamentos, y los que fabrican reactivos y nuevos dispositivos para diagnósticos. Palabras clave: malaria, paludismo, salud pública, saneamientoChallenges for the elimination of malaria in Colombia: A problem of knowledge or of power Introduction. Practices to end malaria in the world have evolved from the sanitary control programs, known in Colombia as the fight for hygiene, in the early twentieth century, to the eradication efforst in the 50's and back to control in 1978. Today, after 43 years of failure of the malaria eradication program, the World Health Organization proposes its members a program to eliminate malaria malaria with eradication in view. Will this be possible in Colombia? Objective. To review the possibilities of eliminating malaria in Colombia, from a historical analysis of the knowledge and practices developed to reach this aim. Results. We present the obstacles and opportunities for the development of a malaria elimination program in Colombia, where the etiopathogenic model of infectious diseases, based on the germ theory, still remains valid and supports practices such as eradication. Conclusion. Eliminating malaria is not just a scientific problem of the gaps in knowledge, but a way of supporting that knowledge with a single theory, the microbial or the etiopathogenic theory, to explain diseases such as malaria; it is also a problem of power. Even though the political power can be a form of knowledge, understanding it as a mixture of strategies and interests of the institutions that dic...

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“…The former was successfully eliminated together with a significant reduction of P. vivax cases in the early 1990s (Sleigh et al, 1998;Lu et al, 2014). The global malaria incidence decreased by 17% between 2000 and 2010 (Feachem et al, 2010;WHO, 2012) and the trend has been similar in P.R. China.…”

Section: Introductionmentioning

confidence: 99%

Elimination of malaria due to Plasmodium vivax in central part of the People’s Republic of China: analysis and prediction based on modelling

et al. 2014

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Abstract. Five provinces in central People's Republic of China (P.R. China) have successfully reduced the burden of malaria due to Plasmodium vivax in the last 7 years. The results of the Action Plan of China Malaria Elimination (APCME) that commenced in 2010 are analysed against the background of the progress reached by the national malaria control programme (NMEP) that was launched in 2006. We examined the epidemiological changes in the number of autochthonous cases over time and discuss the feasibility of achieving the goal of malaria elimination by 2020. There was a total decline of 34,320 malaria cases between 2006 and 2012 arriving at an average annual incidence of 0.04 per 10,000 people by 2012. At the same time, the number of counties reporting autochthonous cases declined from 290 to 19. Spatial autocorrelation and Bayesian modelling were used to evaluate the datasets and predict the spatio-temporal pattern in the near future. The former approach showed that spatial clusters of P. vivax malaria existed in the study region during the study period, while the risk prediction map generated by the Bayesian model indicates that only sporadic malaria cases will appear during in the future. The results suggest that the initial NMEP approach and the follow-up APCME strategy have played a key role in reducing the threat of malaria in central P.R. China. However, to achieve the goal of malaria elimination by the end of the current decade, intervention plans must be adjusted with attention paid to those endemic counties still at risk according to the prediction map.

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Shrinking the malaria map: progress and prospects

Cited by 359 publications

References 64 publications

Clinical Efficacy of Dihydroartemisinin–Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China–Myanmar Border

Clinical Efficacy of Dihydroartemisinin–Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria at the China–Myanmar Border

Challenges for the elimination of malaria in Colombia: A problem of knowledge or of power

Elimination of malaria due to Plasmodium vivax in central part of the People’s Republic of China: analysis and prediction based on modelling

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