Cementless surface replacement arthroplasties are increasingly being used to treat arthritic humeral heads. These implants are designed to provide narrow bone resection, making a later revision easier. However, no clear evidence exists as to whether their initial fixation is sufficient for bony ingrowth. The aim of our in vitro study was to characterize the relative micromotion of two resurfacing implants with essentially different bone-facing geometries. Both systems were implanted into 10 human humeral specimens and micromotion was measured under a cyclic torque application of up to AE1.75 Nm. The mean relative rotary motion resulted in a significant difference (p ¼ 0.036), which was attributed to design differences of central stabilizers featuring both implants. A conversion of rotary motions into relative micromotions, using recently measured moments acting on these implants during daily activities of living, nullified this difference (p ¼ 0.088). However, depending on the shoulder load case considered, a clear difference appeared (p ¼ 0.031-0.045). In conclusion, both resurfacing implants are capable of achieving sufficient initial fixation on the humeral head and perform relative micromotions in a range considered safe for bony ingrowth. Patient-related parameters do not appear to influence the initial fixation of these implants. Keywords: arthroplasty; shoulder; cementless resurfacing; initial fixation; osseointegrationIn the 1950s, Neer 1 established modern shoulder arthroplasty and revolutionized its design with his perception of ''as near as possible to the anatomy.'' Since then designs have undergone many developments, as use of shoulder replacements has increased over the past 40 years. 2 The latest development is towards cementless surface replacement arthroplasties (CSRAs). Their positioning is independent of the humeral cavity and therefore easy to handle in the treatment of patients who have extra-articular deformities that make the placement of a conventional stemmed prosthesis difficult or impossible. 3,4 The design of CSRAs provides a primary press-fit, and in the majority of cases HA coatings should allow for accelerated biological fixation. 5 The benefit is minimal bone loss that facilitates later revision with a conventional total shoulder arthroplasty. 6,7 However, as promising as the implantation of a CSRA seems to be, a recent clinical study showed a high revision rate, 22% after 13 mos due to pain that may be caused by overstuffing of the joint, not resurfacing the glenoid, or loosening of the humeral component. 8 The complication rates in previous studies seem comparable and vary between 3% and 20%. 5,9-11 A further challenge is recognizing aseptic loosening in standard radiographs, since the bony bearing is always occulted by the metal concavity.As we have learned from total hip arthroplasty, initial fixation is the prerequisite for a good long-term success of cementless implants. This largely depends on how tightly the implant is fixed to the bone. 12 Relative micromotions ...