Shoulder Preservation in Spinal Cord Injury: One Clinic’s Approach to Treatment and Prevention

Silvestri, Jennifer

doi:10.1007/s40141-018-0190-0

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…SCI is a fatal damage that brings about severe symptoms, and the prevention and treatment of this injury has aroused more attention [32]. In very recent studies, lncRNA SNHG5 has been shown to promote astrocytes and microglia viability in SCI [33]; and lncRNA ZNF667-AS1 impacts potential function in promoting recovery of SCI [34].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Spinal cord injury (SCI) is a grievous neurology-related disorder that causes many devastating symptoms. This research planned to dig the function and latent mechanisms of long noncoding RNA (lncRNA) ANRIL on hydrogen peroxide (H 2 O 2)-disposed injury in PC-12 cells. The PC-12 cells were disposed with H 2 O 2 for 24 h to construct the SCI model. H 2 O 2-disposed PC-12 cells was assessed by detecting cell viability, migration, invasion, apoptosis and autophagy. The level of ANRIL in H 2 O 2-disposed PC-12 cells was analysed, afterwards, the impacts of ANRIL silencing on H 2 O 2-disposed PC-12 cell injury was determined. The regulatory association between ANRIL and miR-499a, between miR-499a and PDCD4, as well as PDCD4 and PI3K/Akt/mTOR/p70S6K signals were investigated. H 2 O 2 produced PC-12 cell injury and promoted the level of ANRIL. Silencing of ANRIL inhibited H 2 O 2-disposed PC-12 cell injury through promoting cell viability, migration, invasion and inhibiting apoptosis and autophagy. Moreover, miR-499a was upregulated after silencing of ANRIL, and inhibition of miR-499a reversed the effects of silencing of ANRIL on H 2 O 2-disposed PC-12 cell injury. Also, PDCD4 was a target of miR-499a. Furthermore, ANRIL silencing alleviated the H 2 O 2-disposed injury in PC-12 cells possible by activating PI3K/Akt/mTOR/p70S6K signals, which was mediated by miR-499a/PDCD4 axis. Our results indicate that high level of ANRIL may sharpen the degree of SCI via targeting miR-499a/PDCD4 axis to regulate the briskness of PI3K/Akt/mTOR/p70S6K signals.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…SCI is a serious trauma that results in devastating physiological consequences [21]. Increasing interest has been brought to bear on the prevention, treatment and rehabilitation of SCI [22]. Recently, a larger number of lncRNAs are discovered in the spinal cord and their expression level can be changed following SCI, which indicates that lncRNAs might be key regulators in SCI [10].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Long non-coding RNA SNHG16 reduces hydrogen peroxide-induced cell injury in PC-12 cells by up-regulating microRNA-423-5p

Liu

Chen

Zhu

2019

Artificial Cells, Nanomedicine, and Biotechnology

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Functions of long non-coding RNAs (lncRNAs) have been widely probed in spinal cord injury (SCI). But, the influences of lncRNA-small nucleolar RNA host gene 16 (lncRNA-SNHG16) is still not well documented in SCI. The study explored the impacts of SNHG16 on H 2 O 2-injured PC-12 cells. PC-12 cells were disposed with H 2 O 2 , cell viability, apoptosis, autophagy and ROS level were detected. RT-qPCR was executed to explore SNHG16 or miR-423-5p expression in H 2 O 2-stimulated cells. After transfection with pc-SNHG16 or miR-423-5p inhibitor, the functions of SNHG16 and miR-423-5p in H 2 O 2-injured cells were studied. AMPK and ERK1/2 pathways were finally assessed by western blot. We found that H 2 O 2 evoked cell injury in PC-12 cells, and repressed SNHG16 was observed in H 2 O 2-disposed cells. Overexpressed SNHG16 prominently alleviated H 2 O 2-induced cell injury as indicated by repressing cell apoptosis, autophagy and ROS level. Additionally, SNGH16 enhanced miR-423-5p expression, and miR-423-5p inhibition abrogated the protective effect of SNGH16 on H 2 O 2-injured PC-12 cells. SNGH16 mediated AMPK and ERK1/2 pathways via up-regulating miR-423-5p in H 2 O 2-injured PC-12 cells. In conclusion, these findings indicated that SNGH16 reduced H 2 O 2-evoked cell injury by mediating miR-423-5p in PC-12 cells. The findings might uncover the effect of SNHG16 on SCI, which provide a new reference for remedying SCI. HIGHLIGHTS 1. H 2 O 2 evokes cell injury in PC-12 cells; 2. SNHG16 reduces H 2 O 2-induced cell injury in PC-12 cells; 3. SNGH16 enhances miR-423-5p expression in H 2 O 2-stimulated PC-12 cells; 4. MiR-423-5p inhibition abrogates the protective effect of SNGH16 in PC-12 cells; 5. SNGH16 mediates AMPK and ERK1/2 pathways by up-regulating miR-423-5p.

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“…In addition to these objective measures, patient-reported outcome measures, such as quality of life and satisfaction with treatment, have also been used [ 88 , 89 ]. These measures provide valuable information about the patient’s subjective experience and can help in assessing the overall impact of an intervention on their well-being.…”

Section: Technology Solutions For Home-based Shoulder Rehabilitationmentioning

confidence: 99%

Home-Based Rehabilitation of the Shoulder Using Auxiliary Systems and Artificial Intelligence: An Overview

Cunha

Ferreira

Sousa

2023

Sensors

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Advancements in modern medicine have bolstered the usage of home-based rehabilitation services for patients, particularly those recovering from diseases or conditions that necessitate a structured rehabilitation process. Understanding the technological factors that can influence the efficacy of home-based rehabilitation is crucial for optimizing patient outcomes. As technologies continue to evolve rapidly, it is imperative to document the current state of the art and elucidate the key features of the hardware and software employed in these rehabilitation systems. This narrative review aims to provide a summary of the modern technological trends and advancements in home-based shoulder rehabilitation scenarios. It specifically focuses on wearable devices, robots, exoskeletons, machine learning, virtual and augmented reality, and serious games. Through an in-depth analysis of existing literature and research, this review presents the state of the art in home-based rehabilitation systems, highlighting their strengths and limitations. Furthermore, this review proposes hypotheses and potential directions for future upgrades and enhancements in these technologies. By exploring the integration of these technologies into home-based rehabilitation, this review aims to shed light on the current landscape and offer insights into the future possibilities for improving patient outcomes and optimizing the effectiveness of home-based rehabilitation programs.

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Shoulder Preservation in Spinal Cord Injury: One Clinic’s Approach to Treatment and Prevention

Cited by 6 publications

References 39 publications

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

RETRACTED ARTICLE: Long non-coding RNA SNHG16 reduces hydrogen peroxide-induced cell injury in PC-12 cells by up-regulating microRNA-423-5p

Home-Based Rehabilitation of the Shoulder Using Auxiliary Systems and Artificial Intelligence: An Overview

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