Should there be a specific length of the colon-rectum segment to be resected for an adequate number of lymph nodes in cases of colorectal cancers? A retrospective multi-center study

Abstract

al. Should there be a specific length of the colon-rectum segment to be resected for an adequate number of lymph nodes in cases of colorectal cancers? A retrospective multi-center study.

Association between the number of retrieved lymph nodes and demographic/tumour-related characteristics in colorectal cancer: a systematic review and meta-analysis

“…In the systematic review, six articles showed that tumour location was not significantly associated with the LN yield in colorectal cancer25 26 35 40 64 65; however, four articles revealed association, without explaining the specific association 5 34 36 63. Ten articles revealed that more LNs could be obtained from the right colon than the other locations 21 22 25 29 31 37 39 41 44 48.…”

“…From these articles, 90 articles were excluded because the papers were not in English or Chinese (n=2), had unavailable data (n=23) and were unrelated (n=65). Finally, 54 studies were included, with 30 included in the systematic review,5 19–47 and 24 in the meta-analysis (figure 1). 12–14 48–68…”

“…The analysis of gender and retrieved LNs in colorectal cancer using systematic review included ten colorectal cancer,21 26 27 31 32 36 37 39 41 51 five colon cancer22 30 35 44 47 and five rectal cancer studies 23 38 42 54 65. These studies showed that gender had no significant association with the LN yield.…”

“…In the systematic review of association between the T stage and LN yield in colorectal cancer, 12 studies mentioned that the T stage had no significant association with the LN yield,23 26 29 30 32 35 39 40 42 44 47 54 but eight articles revealed that more LNs were obtained from the advanced T stage than early T stage 21 25 27 28 37 41 51 62. Moreover, four articles mentioned that the T stage was associated with the harvested LNs,19 24 36 48 without explaining the specific association. In the meta-analysis, seven studies containing 23 297 patients with colorectal cancer revealed higher LN yield in the T3+T4 group than the T1+T2 group (OR=1.57, 95% CI (1.25 to 1.97), p<0.001, I 2 =70.46%) (figure 2 and online supplemental figure 11).…”

Influence of colonic mesenteric area on the number of lymph node retrieval for colon cancer: a prospective cohort study

“…Although there were controversial results concerning the association of the length of resected bowel and the LN yield [1,3,10,11,14,15], some authors also tried to find the cutoff values of specimen lengths for adequate LN counts. They showed that there should be almost < 20 cm of specimen length for sufficient LN counts [22,23]. They evaluated both colon and rectal cancers in their study that can be regarded as a confounding factor.…”