Should Management of Complete Atrioventricular Canal Defect Be Influenced by Coexistent Down Syndrome?

Bull, Catherine; Rigby, M; Shinebourne, E A

doi:10.1016/s0140-6736(85)92444-4

Cited by 49 publications

(20 citation statements)

References 13 publications

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“…In the two year study period a total of 81 babies were referred either by clinicians (69) or by the genetics service (12) and screened for congenital heart disease. Fifty three were boys and 28 girls.…”

Section: Incidence Of Congenital Heart Diseasementioning

confidence: 99%

Congenital heart disease in Down's syndrome: two year prospective early screening study.

Tubman

Shields

Craig

et al. 1991

BMJ

106

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Section: Incidence Of Congenital Heart Diseasementioning

confidence: 99%

Congenital heart disease in Down's syndrome: two year prospective early screening study.

Tubman

Shields

Craig

et al. 1991

BMJ

106

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“…7,8 Related complications, such as pulmonary hypertension and heart failure may affect health and survival, 9 but a change in attitudes toward treatment of infants with Down syndrome, corrective heart surgery included, has improved prognosis. 10,11 For example, the infant mortality rate among infants with Down syndrome in Sweden has decreased from 41% during 1969 to 1973 to 4% during 1999 to 2003. 9 Recent studies from Norway and Canada have demonstrated small declines in the incidence of congenital heart defects over time in the general population.…”

mentioning

confidence: 99%

Trends in Congenital Heart Defects in Infants With Down Syndrome

Bergström¹,

Carr²,

Petersson³

et al. 2016

Pediatrics

124

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“…Recently, the survival rates of children with DS and concomitant congenital heart defect (CHD) have considerably improved. In the group of children with endocardial cushion defects, 80% of patients live as long as 15 years [4]. The most frequent causes of death are respiratory tract infections and consequences of CHD such as congestive heart failure and pulmonary hypertension, a particularly dangerous condition which develops earlier in children with Down's syndrome and has a more violent course.…”

mentioning

confidence: 99%

Results of Surgical Treatment of Congenital Heart Defects in Children with Down's Syndrome

et al. 1999

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We analyzed early and late results of surgical treatment of 100 consecutive children with Down's syndrome (DS) and congenital heart defect (CHD) who were operated on between 1990 and 1997. Fifty had common atrioventricular canal (CAVC), 24 ventricular septal defect, 8 the ostium primum atrial septal defect, 8 tetralogy of Fallot (TOF), 3 patent ductus arteriosus, 3 the ostium secundum atrial septal defect, and 4 CAVC coexisting with TOF. In 93 patients total correction was performed. The total death rate was 6%. Death in the CAVC group was 8%, but it decreased to 2.7% during the past 3 years. The children who were followed up (from 7 months to 6 years; mean, 39 months) are in NYHA class I or II. There were no reoperations. The postoperative course was complicated by pulmonary infections in 38% of patients, which converted to generalized infection in 10% and was the cause of death in 8% of patients. These results indicate that CHD in DS children can be repaired with a low death rate and low incidence of severe mitral atrioventricular valve regurgitation in the CAVC group. A high incidence of severe infections can influence the final results. Repair of CHD in infancy helps to eliminate problems connected with congestive heart failure and pulmonary hypertension.

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Should Management of Complete Atrioventricular Canal Defect Be Influenced by Coexistent Down Syndrome?

Cited by 49 publications

References 13 publications

Congenital heart disease in Down's syndrome: two year prospective early screening study.

Congenital heart disease in Down's syndrome: two year prospective early screening study.

Trends in Congenital Heart Defects in Infants With Down Syndrome

Results of Surgical Treatment of Congenital Heart Defects in Children with Down's Syndrome

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