Should Female Partners of Men With Non-Gonococcal Urethritis, Negative for Chlamydia trachomatis and Mycoplasma genitalium, Be Informed and Treated? Clinical Outcomes From a Partner Study of Heterosexual Men With NGU

Ong, Jason J.; Sarumpaet, Angela; Chow, Eric P F; Bradshaw, Catriona; Chen, Marcus; Read, Tim; Fairley, Christopher K.

doi:10.1097/olq.0000000000000546

Cited by 2 publications

(1 citation statement)

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“…Non-gonococcal urethritis (NGU) is one of the most common sexually transmitted infections caused by Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae (1). Mycoplasma, the pathogen of NGU, can adhere to the surface of the genitourinary tract, resulting in an epithelial infection (2). In recent years, with changes in life-style and sexual behavior of people, the incidence of NGU is increasing, and the primary clinical manifestation is urethritis, generating a serious impact on the quality of life and health of people (3).…”

Section: Introductionmentioning

confidence: 99%

Azithromycin combined with doxycycline in non‑gonococcal urethritis

Hou

et al. 2020

Exp Ther Med

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Non-gonococcal urethritis (NGU) is one of the most common sexually transmitted diseases caused by chlamydia or mycoplasma. The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6).A total of 98 patients with non-gonococcal urethritis were prospectively selected, of which 46 patients were assigned to an azithromycin group (treated with azithromycin alone), while the rest were assigned to a combination group (treated with azithromycin and doxycycline). The conditions of the patients were evaluated and compared between the two groups. The treatment efficacy in patients in the combination group was significantly better than that in the azithromycin group, and the time to symptom relief, period of medication, recurrence rate within 1 year of withdrawal and level of serum IL-6 in the combination group were significantly lower than those in the azithromycin group. The quality of life of patients in the combination group was significantly improved compared to those in the azithromycin group. However, there was no significant difference in the incidence of adverse reactions between the two groups. Azithromycin combined with doxycycline was revealed to be more effective than azithromycin monotherapy for NGU.

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Section: Introductionmentioning

confidence: 99%