Azithromycin combined with doxycycline in non‑gonococcal urethritis

Abstract

Non-gonococcal urethritis (NGU) is one of the most common sexually transmitted diseases caused by chlamydia or mycoplasma. The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6).A total of 98 patients with non-gonococcal urethritis were prospectively selected, of which 46 patients were assigned to an azithromycin group (treated with azithromycin alone), while the rest were assigned to a combination group (treated with azithromycin and doxycycline). The conditions of the patients were evaluated and compared between the two groups. The treatment efficacy in patients in the combination group was significantly better than that in the azithromycin group, and the time to symptom relief, period of medication, recurrence rate within 1 year of withdrawal and level of serum IL-6 in the combination group were significantly lower than those in the azithromycin group. The quality of life of patients in the combination group was significantly improved compared to those in the azithromycin group. However, there was no significant difference in the incidence of adverse reactions between the two groups. Azithromycin combined with doxycycline was revealed to be more effective than azithromycin monotherapy for NGU.

Recent Advances in Treatment of Recurrent Spontaneous Abortion

“…Quinolones are recommended as second-line therapeutic drugs, but they are susceptible to produce drug resistance when used alone for a long time. Clinical studies have shown that azithromycin combined with doxycycline is more effective than azithromycin alone, and there was no significant difference in the incidence of adverse reactions between the 2 usages 41 . Sitafloxacin (STFX) is an alternative drug for the treatment of azithromycin-resistant Mycoplasma genitalium .…”

“…Clinical studies have shown that azithromycin combined with doxycycline is more effective than azithromycin alone, and there was no significant difference in the incidence of adverse reactions between the 2 usages. 41 Sitafloxacin (STFX) is an alternative drug for the treatment of azithromycin-resistant Mycoplasma genitalium . In a clinical trial, the eradication rates of STFX on CT, MG, MH, UU, and Ureaplasma parvum were 96.1%, 71.4%, 100%, 85.7%, and 100%, respectively; STFX was shown to be useful not only for respiratory therapy but also for urinary tract infection, although its drug resistance required further study and observation.…”

Effect of long noncoding RNA CCAT2 on drug sensitivity to 5‐fluorouracil of breast cancer cells through microRNA‐145 meditated by p53

“…[ 3 ] Radiotherapy and chemotherapy have been considered main treatments for BC; however, their efficacy falls short of the expectation mainly because of the drug resistance, which is thought as the main cause of cancer recurrence. [ 4,5 ] 5‐Fluorouracil (5‐Fu), a sort of DNA damaging drug which promotes cancer cell apoptosis, has been extensively applied as an anticancer agent in tumors in several vital organs including the colon, head, pancreas, breast, liver, and stomach for decades. [ 6,7 ] However, one previous report clarified that about 30% of BC patients were shown drug resistance when treated with 5‐Fu for the first time.…”