Should children be vaccinated against COVID-19 now?

Wong, Brian Li Han; Ramsay, Mary; Ladhani, Shamez

doi:10.1136/archdischild-2020-321225

Cited by 41 publications

(45 citation statements)

References 5 publications

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“…Data from the first wave of the pandemic indicated very low hospitalisation and case fatality rates even in children with comorbidities, but older children with severe neurodisability were over-represented among severe and fatal cases. 38 Consequently, the UK recommended COVID-19 vaccines for adolescents with severe neurodisability as soon as a vaccine was authorised in adults (and prior to authorisation in adolescents) in order to protect this vulnerable group as quickly as possible. 38 Now that an authorised vaccine is available for adolescents, current recommendations could be widened to include more risk groups in children, but we need robust data on both the relative and absolute risks of severe COVID-19 in children with specific comorbidities.…”

Section: Currently Available Optionsmentioning

confidence: 99%

“…38 Consequently, the UK recommended COVID-19 vaccines for adolescents with severe neurodisability as soon as a vaccine was authorised in adults (and prior to authorisation in adolescents) in order to protect this vulnerable group as quickly as possible. 38 Now that an authorised vaccine is available for adolescents, current recommendations could be widened to include more risk groups in children, but we need robust data on both the relative and absolute risks of severe COVID-19 in children with specific comorbidities. At the same time, however, it is not possible to identify children who might be at increased risk of PIMS-TS or long COVID and, therefore, vaccination cannot be targeted specifically towards children at risk for these complications.…”

Section: Currently Available Optionsmentioning

confidence: 99%

“…Another possible option would be to vaccinate specific cohorts of children, such as those with underlying comorbidities that increases their risk of COVID-19. Data from the first wave of the pandemic indicated very low hospitalisation and case fatality rates even in children with co-morbidities, but older children with severe neurodisability were over-represented among severe and fatal cases 38 . Consequently, the UK recommended COVID-19 vaccines for adolescents with severe neurodisability as soon as a vaccine was authorised in adults (and prior to authorisation in adolescents) in order to protect this vulnerable group as quickly as possible 38 .…”

Section: Introductionmentioning

confidence: 99%

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Crossing the Rubicon: A fine line between waiting and vaccinating adolescents against COVID-19

Ladhani

2021

Journal of Infection

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Currently Available Optionsmentioning

confidence: 99%

Section: Currently Available Optionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Crossing the Rubicon: A fine line between waiting and vaccinating adolescents against COVID-19

Ladhani

2021

Journal of Infection

Self Cite

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“…Therefore, vaccinating children and adolescents may be necessary to effectively prevent the spread of COVID-19 infections. [58][59][60] In the US, with the ongoing COVID-19 vaccinations in adults together with schools reopening, the proportion of COVID-19 confirmed cases in children has increased from 13.6% to nearly 21%. 61) Therefore, in Korea, after the vaccine rollout, careful monitoring of the proportion of children confirmed with COVID-19 is important.…”

Section: Covid-19 Vaccine In Children and Adolescentsmentioning

confidence: 99%

Updates on the coronavirus disease 2019 vaccine and consideration in children

Choi

Kim

2021

Clin Exp Pediatr

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Humanity has been suffering from the global severe acute respiratory syndrome coronavirus 2 pandemic that began late in 2019. In 2020, for the first time in history, new vaccine platforms-including mRNA vaccines and viral vector-based DNA vaccines-have been given emergency use authorization, leading to mass vaccinations. The purpose of this article is to review the currently most widely used coronavirus disease 2019 vaccines, investigate their immunogenicity and efficacy data, and analyze the vaccine safety profiles that have been published, to date.

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“…Some experts recommend ‘off-label’ vaccination of children in this age group who are considered ‘high-risk’ (eg, Down Syndrome and Cerebral Palsy). 5 When they get sick, children suffer from longer illness and more long-lasting symptoms and syndromes. 6 This information was not known when the vaccine trials started.…”

Section: Introductionmentioning

confidence: 99%

Voluntary COVID-19 vaccination of children: a social responsibility

Brusa

Barilan

2021

J Med Ethics

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Nearly 400 million adults have been vaccinated against COVID-19. Children have been excluded from the vaccination programmes owing to their lower vulnerability to COVID-19 and to the special protections that apply to children’s exposure to new biological products. WHO guidelines and national laws focus on medical safety in the process of vaccine approval, and on national security in the process of emergency authorisation. Because children suffer much from social distancing, it is argued that the harms from containment measures should be factored in a broader perspective on the good of the child. Considering the available knowledge on the disease, vaccine, and coping strategies, the decision about vaccine access to children is a public responsibility. The ultimate choice is a matter of paediatric informed consent. Moreover, jurisdictions that permit non-participation in established childhood vaccination programmes should also permit choice of vaccines outside of the approved programmes. Even if vaccine supply is too short to cover the paediatric population, the a priori exclusion of children is unjust. It may also exacerbate local and global inequalities. The second part of the paper delineates a prudent and ethical scheme for gradual incorporation of minors in vaccination programmes that includes a rigorous postvaccination monitoring. This is a theoretical paper in ethics that uses the Pfizer vaccine as a stock example, without discussing possible differences among existing vaccines. The key purpose is reflection on the good of the child in emergencies and vaccine policymaking.

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Should children be vaccinated against COVID-19 now?

Cited by 41 publications

References 5 publications

Crossing the Rubicon: A fine line between waiting and vaccinating adolescents against COVID-19

Crossing the Rubicon: A fine line between waiting and vaccinating adolescents against COVID-19

Updates on the coronavirus disease 2019 vaccine and consideration in children

Voluntary COVID-19 vaccination of children: a social responsibility

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